Assessment of used medications and drug-drug interactions among chronic renal failure patients

• Autor(a) principal: Sgnaolin, Vanessa
• Data de Publicação: 2014
• Outros Autores: Sgnaolin, Valéria, Engroff, Paula, De Carli, Geraldo Attilio, Prado Lima Figueiredo, Ana Elizabeth
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Scientia Medica (Porto Alegre. Online)
• Texto Completo: https://revistaseletronicas.pucrs.br/scientiamedica/article/view/17637
• topic: DRUG INTERACTIONS; RENAL INSUFFICIENCY; CHRONIC; HEMODIALYSIS UNITS; HOSPITAL; INTERAÇÕES DE MEDICAMENTOS; INSUFICIÊNCIA RENAL CRÔNICA; UNIDADES HOSPITALARES DE HEMODIÁLISE; Nefrologia; Farmácia

AIMS: To describe the drugs most frequently used by patients in hemodialysis and to identify potential drug-drug interactions. METHODS: Cross-sectional study conducted in a hospital hemodialysis unit. Each combination of drugs prescription was analyzed in Micromedex©2014 Truven Health Analytics (Michigan, United States), to identify potential drug-drug interactions and classify them according to severity. RESULTS: Sixty-five patients were included. The mean age was 59.1±14.7 years and 50.8% were women. The occurrence of polypharmacy was 87.7%, with average of 6.3±3.1 medications/patient, the most frequent being calcium carbonate (n=55, 84.6%) and erythropoietin (n=47, 72.3%). The prevalence of potential drug-drug interactions was 56.9%, with median of one interaction per patient, and most were classified as moderate (49.1%) being the most frequent atenolol/calcium carbonate (n=9, 8.0%) and iron/calcium carbonate (n=9, 8.0%). The presence and number of potential moderate or important drug-drug interactions were significantly associated with the number of drugs used by the patient (P