Anticardiolipin antibodies and recurrent spontaneous abortion in Brazilian women
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Scientia Medica (Porto Alegre. Online) |
Texto Completo: | https://revistaseletronicas.pucrs.br/scientiamedica/article/view/18581 |
Resumo: | Aims: To determine the frequency of anti-cardiolipin antibodies (aCL) in women with previous history of recurrent spontaneous abortion (RSA). Methods: Medical records from pregnant women seen from April 2005 to December 2008 at the High-Risk Pregnancy Unit at the Hospital de Base from FUNFARME (Fundação Faculdade Regional de Medicina), in São José do Rio Preto, São Paulo, Brazil, were revised. Patients older than 18 years who had at least two spontaneous abortions and who were tested for aCL were included in the study. Data on maternal age, number of miscarriages and the results of serological tests for aCL were recorded. The exact Fisher’s test was used to compare the results. A p value less than 0.05 was considered significant.Results: During the study period a total of 294 pregnant women were seen, from whom 44 consecutive women fulfilled the inclusion criteria. The overall mean age was 33.8±5.4 years (range: 22 to 44; median: 34). Eighteen (40.9%) patients were reagent for aCL and 26 (59.1%) non-reagent, and the difference between their mean age was not statistically significant (reagent: 34.6±5.8 years; non reagent: 33.2±5.2 years, p=0.4001). Fourteen (77.8%) patients presented IgM aCL and six (33.2%), IgG aCL. Two patients (11%) were reagent for both IgM and IgG aCL. In the most of cases the aCL antibody titers were compatible with low risk for pregnancy morbidity. The number of abortions ranged from two to six. The average number of abortions among those reagent for aCL was 3.5±1.1 and in those non-reagent was 2.9±1.1 (p=0.0813).Conclusions: The frequency of aCL was elevated among patients with a history of RSA, especially those having higher number of fetal losses. Among women with at least two spontaneous abortions, the mean number of abortions was not significantly different between those reagent for aCL and those non reagent. |
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Anticardiolipin antibodies and recurrent spontaneous abortion in Brazilian womenAnticorpos anticardiolipina e abortos espontâneos recorrentes em mulheres brasileirasAntibodiesanticardiolipinantiphospholipidAbortionspontaneousMiscarriagerecurrentImmunological markersFetal deathHigh risk pregnancy.RSAantiphospholipid antibodiesabortionimmunological markersfetal losshigh risk pregnancyAnticorpos anticardiolipinaAnticorpos antifosfolipídicosAborto espontâneoAborto habitualMarcadores imunológicosMorte fetalGestação de alto risco.Aims: To determine the frequency of anti-cardiolipin antibodies (aCL) in women with previous history of recurrent spontaneous abortion (RSA). Methods: Medical records from pregnant women seen from April 2005 to December 2008 at the High-Risk Pregnancy Unit at the Hospital de Base from FUNFARME (Fundação Faculdade Regional de Medicina), in São José do Rio Preto, São Paulo, Brazil, were revised. Patients older than 18 years who had at least two spontaneous abortions and who were tested for aCL were included in the study. Data on maternal age, number of miscarriages and the results of serological tests for aCL were recorded. The exact Fisher’s test was used to compare the results. A p value less than 0.05 was considered significant.Results: During the study period a total of 294 pregnant women were seen, from whom 44 consecutive women fulfilled the inclusion criteria. The overall mean age was 33.8±5.4 years (range: 22 to 44; median: 34). Eighteen (40.9%) patients were reagent for aCL and 26 (59.1%) non-reagent, and the difference between their mean age was not statistically significant (reagent: 34.6±5.8 years; non reagent: 33.2±5.2 years, p=0.4001). Fourteen (77.8%) patients presented IgM aCL and six (33.2%), IgG aCL. Two patients (11%) were reagent for both IgM and IgG aCL. In the most of cases the aCL antibody titers were compatible with low risk for pregnancy morbidity. The number of abortions ranged from two to six. The average number of abortions among those reagent for aCL was 3.5±1.1 and in those non-reagent was 2.9±1.1 (p=0.0813).Conclusions: The frequency of aCL was elevated among patients with a history of RSA, especially those having higher number of fetal losses. Among women with at least two spontaneous abortions, the mean number of abortions was not significantly different between those reagent for aCL and those non reagent.Objetivos: Avaliar a frequência de anticorpos anticardiolipina (aCL) em mulheres com história prévia de aborto espontâneo recorrente (AER).Métodos: No período de abril de 2005 a dezembro de 2008 foram avaliados os dados de prontuários de gestantes atendidas no Ambulatório de Gestação de Alto Risco do Hospital de Base da Fundação Faculdade Regional de Medicina (FUNFARME), em São José do Rio Preto, São Paulo, Brasil. Foram incluídas neste estudo pacientes com idade acima de 18 anos que tiveram pelo menos dois abortos espontâneos e foram avaliadas para aCL. O teste exato de Fisher foi usado para comparar os resultados. Valor de p menor que 0,05 foi considerado significante.Resultados: Um total de 294 mulheres gestantes foram avaliadas durante o período do estudo, das quais 44 atendiam aos critérios de inclusão. A média de idade foi 33,8±5,4 anos (variação: 22 a 44; mediana: 34). Dezoito pacientes (40,9%) foram reagentes para aCL e 26 (59,1%) não reagentes, e a diferença entre a média de idade não foi estatisticamente significante (reagentes: 34,6±5,8 anos; não reagentes: 33,2±5,2 anos, p=0,4001). Quatorze (77,8%) pacientes apresentaram aCL IgM e seis (33,2%) aCL IgG. Duas pacientes (11%) foram reagentes para ambas as classes de aCL, IgM e IgG. Na maioria dos casos os títulos de anticorpos aCL foram compatíveis com baixo risco para morbidade na gravidez. O número de abortos variou de dois a seis. O número médio de abortos entre as reagentes para aCL foi de 3,5±1,1 e entre as não reagentes foi de 2,9±1,1 (p=0,0813).Conclusões: A frequência de aCL foi alta entre as pacientes com história de AER, especialmente entre aquelas que tiveram um maior número de perdas fetais. Entre as mulheres com pelo menos dois abortos espontâneos, a média do número de abortos não foi significativamente diferente entre aquelas reagentes e não reagentes para aCL.Editora da PUCRS - ediPUCRS2015-03-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/1858110.15448/1980-6108.2015.1.18581Scientia Medica; Vol. 25 No. 1 (2015); ID18581Scientia Medica; v. 25 n. 1 (2015); ID185811980-61081806-556210.15448/1980-6108.2015.1reponame:Scientia Medica (Porto Alegre. Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSenghttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/18581/13502Santos Santana, NatáliaCosentinio Junqueira Franco Spegiorin, LígiaPontes Ferreira, CamilaMós Vaz-Oliani, Denise CristinaOliani, Antonio HélioPereirade Godoy, José MariaBrandão de Mattos, Cinara Cássiade Mattos, Luiz Carlosinfo:eu-repo/semantics/openAccess2018-08-09T03:04:37Zoai:ojs.revistaseletronicas.pucrs.br:article/18581Revistahttps://revistaseletronicas.pucrs.br/scientiamedica/PUBhttps://revistaseletronicas.pucrs.br/scientiamedica/oaiscientiamedica@pucrs.br || editora.periodicos@pucrs.br1980-61081806-5562opendoar:2018-08-09T03:04:37Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false |
dc.title.none.fl_str_mv |
Anticardiolipin antibodies and recurrent spontaneous abortion in Brazilian women Anticorpos anticardiolipina e abortos espontâneos recorrentes em mulheres brasileiras |
title |
Anticardiolipin antibodies and recurrent spontaneous abortion in Brazilian women |
spellingShingle |
Anticardiolipin antibodies and recurrent spontaneous abortion in Brazilian women Santos Santana, Natália Antibodies anticardiolipin antiphospholipid Abortion spontaneous Miscarriage recurrent Immunological markers Fetal death High risk pregnancy. RSA antiphospholipid antibodies abortion immunological markers fetal loss high risk pregnancy Anticorpos anticardiolipina Anticorpos antifosfolipídicos Aborto espontâneo Aborto habitual Marcadores imunológicos Morte fetal Gestação de alto risco. |
title_short |
Anticardiolipin antibodies and recurrent spontaneous abortion in Brazilian women |
title_full |
Anticardiolipin antibodies and recurrent spontaneous abortion in Brazilian women |
title_fullStr |
Anticardiolipin antibodies and recurrent spontaneous abortion in Brazilian women |
title_full_unstemmed |
Anticardiolipin antibodies and recurrent spontaneous abortion in Brazilian women |
title_sort |
Anticardiolipin antibodies and recurrent spontaneous abortion in Brazilian women |
author |
Santos Santana, Natália |
author_facet |
Santos Santana, Natália Cosentinio Junqueira Franco Spegiorin, Lígia Pontes Ferreira, Camila Mós Vaz-Oliani, Denise Cristina Oliani, Antonio Hélio Pereirade Godoy, José Maria Brandão de Mattos, Cinara Cássia de Mattos, Luiz Carlos |
author_role |
author |
author2 |
Cosentinio Junqueira Franco Spegiorin, Lígia Pontes Ferreira, Camila Mós Vaz-Oliani, Denise Cristina Oliani, Antonio Hélio Pereirade Godoy, José Maria Brandão de Mattos, Cinara Cássia de Mattos, Luiz Carlos |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Santos Santana, Natália Cosentinio Junqueira Franco Spegiorin, Lígia Pontes Ferreira, Camila Mós Vaz-Oliani, Denise Cristina Oliani, Antonio Hélio Pereirade Godoy, José Maria Brandão de Mattos, Cinara Cássia de Mattos, Luiz Carlos |
dc.subject.por.fl_str_mv |
Antibodies anticardiolipin antiphospholipid Abortion spontaneous Miscarriage recurrent Immunological markers Fetal death High risk pregnancy. RSA antiphospholipid antibodies abortion immunological markers fetal loss high risk pregnancy Anticorpos anticardiolipina Anticorpos antifosfolipídicos Aborto espontâneo Aborto habitual Marcadores imunológicos Morte fetal Gestação de alto risco. |
topic |
Antibodies anticardiolipin antiphospholipid Abortion spontaneous Miscarriage recurrent Immunological markers Fetal death High risk pregnancy. RSA antiphospholipid antibodies abortion immunological markers fetal loss high risk pregnancy Anticorpos anticardiolipina Anticorpos antifosfolipídicos Aborto espontâneo Aborto habitual Marcadores imunológicos Morte fetal Gestação de alto risco. |
description |
Aims: To determine the frequency of anti-cardiolipin antibodies (aCL) in women with previous history of recurrent spontaneous abortion (RSA). Methods: Medical records from pregnant women seen from April 2005 to December 2008 at the High-Risk Pregnancy Unit at the Hospital de Base from FUNFARME (Fundação Faculdade Regional de Medicina), in São José do Rio Preto, São Paulo, Brazil, were revised. Patients older than 18 years who had at least two spontaneous abortions and who were tested for aCL were included in the study. Data on maternal age, number of miscarriages and the results of serological tests for aCL were recorded. The exact Fisher’s test was used to compare the results. A p value less than 0.05 was considered significant.Results: During the study period a total of 294 pregnant women were seen, from whom 44 consecutive women fulfilled the inclusion criteria. The overall mean age was 33.8±5.4 years (range: 22 to 44; median: 34). Eighteen (40.9%) patients were reagent for aCL and 26 (59.1%) non-reagent, and the difference between their mean age was not statistically significant (reagent: 34.6±5.8 years; non reagent: 33.2±5.2 years, p=0.4001). Fourteen (77.8%) patients presented IgM aCL and six (33.2%), IgG aCL. Two patients (11%) were reagent for both IgM and IgG aCL. In the most of cases the aCL antibody titers were compatible with low risk for pregnancy morbidity. The number of abortions ranged from two to six. The average number of abortions among those reagent for aCL was 3.5±1.1 and in those non-reagent was 2.9±1.1 (p=0.0813).Conclusions: The frequency of aCL was elevated among patients with a history of RSA, especially those having higher number of fetal losses. Among women with at least two spontaneous abortions, the mean number of abortions was not significantly different between those reagent for aCL and those non reagent. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-03-10 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/18581 10.15448/1980-6108.2015.1.18581 |
url |
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/18581 |
identifier_str_mv |
10.15448/1980-6108.2015.1.18581 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/18581/13502 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Editora da PUCRS - ediPUCRS |
publisher.none.fl_str_mv |
Editora da PUCRS - ediPUCRS |
dc.source.none.fl_str_mv |
Scientia Medica; Vol. 25 No. 1 (2015); ID18581 Scientia Medica; v. 25 n. 1 (2015); ID18581 1980-6108 1806-5562 10.15448/1980-6108.2015.1 reponame:Scientia Medica (Porto Alegre. Online) instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) instacron:PUC_RS |
instname_str |
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
instacron_str |
PUC_RS |
institution |
PUC_RS |
reponame_str |
Scientia Medica (Porto Alegre. Online) |
collection |
Scientia Medica (Porto Alegre. Online) |
repository.name.fl_str_mv |
Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
repository.mail.fl_str_mv |
scientiamedica@pucrs.br || editora.periodicos@pucrs.br |
_version_ |
1809101750616981504 |