Oxidative aspects of metabolic syndrome and atherosclerosis

• Autor(a) principal: Barbalho, Sandra Maria
• Data de Publicação: 2015
• Outros Autores: Quesada, Karina, Goulart, Ricardo de Alvares, Bechara, Marcelo Dib, Gabaldi, Márcia Rocha, Almeida, Gabriela L. dos Santos, Gasparini, Rodrigo Galhardi
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Scientia Medica (Porto Alegre. Online)
• Texto Completo: https://revistaseletronicas.pucrs.br/scientiamedica/article/view/21092
• topic: metabolic syndrome x; oxidative stress; atherosclerosis.; síndrome x metabólica; estresse oxidativo; aterosclerose.

Aims: To review the literature on the current aspects of oxidative stress and its role in metabolic syndrome and in atherosclerosis.Methods: The study was performed in April and May 2015 and the following databases were used: PubMed, SciELO, and LILACS, including articles published from 2011 onwards. The following keywords were used: oxidative stress and atherosclerosis or oxidative stress and metabolic syndrome. Meta-analyses and clinical trials with a large sample size were preferred.Results: A total of 3,934 articles were available in the databases (PubMed 3,292; SciELO 588; and LILACS 54). Fifty-three articles were included in the review after eliminating double references and using the inclusion criteria.Conclusions: Biochemical and anthropometric findings characteristic of the metabolic syndrome are related to inflammatory processes and to oxidative stress which, in turn, are closely related to atherosclerosis. A better understanding of how the conditions that underlie metabolic syndrome predispose to oxidative stress may significantly contribute to the treatment of patients with cardiovascular disease in the future.