An?lise de par?metros psiconeuroimunol?gicos em longevos saud?veis

Detalhes bibliográficos
Autor(a) principal: Oliveira, ?gatha Schommer de
Data de Publicação: 2014
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da PUC_RS
Texto Completo: http://tede2.pucrs.br/tede2/handle/tede/5498
Resumo: Healthy aging is characterized by the ability of the immune system in preserve some of their functions intact, avoiding the appearance of some age-related diseases and thus contributing to reaching longevity. Furthermore, healthy aging is associated to a better stress coping. Studies have demonstrated immunological changes occurred in old individuals, as well as the consequences of stress on aging. However, few studies have addressed such changes in very old subjects. Here, we analyzed emotional factors and the changes in the lymphocytes subpopulations involved on aging, and the role of these changes to reach longevity healthily. A group of twenty healthy very old subjects together with a group of healthy old individuals and a groups of healthy young adults were recruited in this study. Stress levels were assessed by Perceived Stress Scale (PSS), while depression levels were investigated by Beck Depression Inventories II (BDI-II). Lymphocytes were isolated and assessed by flow cytometry. We observed some age-related changes in lymphocyte subpopulations. In particular, it was evidenced a similar CD4/CD8 ratio between very old subjects and young adults, with this rate being increased in old subjects. A significant increase in the percentage of Natural Killer cells (CD56+CD16+) was observed in the very old subjects, showing that the activity of these cells is well preserved in this group of subjects. Also, we noticed that very old subjects are less stressed, when compared to the other groups. Our data suggests that the combination between increasing and decreasing specific immune functions may generate a balance in the immune system, contributing to reach longevity healthily.
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spelling Bauer, Mois?s EvandroCPF:65934288091http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4798647T5CPF:02409139060http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4490307U8Oliveira, ?gatha Schommer de2015-04-14T14:51:33Z2014-07-312014-03-25OLIVEIRA, ?gatha Schommer de. An?lise de par?metros psiconeuroimunol?gicos em longevos saud?veis. 2014. 46 f. Disserta??o (Mestrado em Biologia Celular e Molecular) - Pontif?cia Universidade Cat?lica do Rio Grande do Sul, Porto Alegre, 2014.http://tede2.pucrs.br/tede2/handle/tede/5498Healthy aging is characterized by the ability of the immune system in preserve some of their functions intact, avoiding the appearance of some age-related diseases and thus contributing to reaching longevity. Furthermore, healthy aging is associated to a better stress coping. Studies have demonstrated immunological changes occurred in old individuals, as well as the consequences of stress on aging. However, few studies have addressed such changes in very old subjects. Here, we analyzed emotional factors and the changes in the lymphocytes subpopulations involved on aging, and the role of these changes to reach longevity healthily. A group of twenty healthy very old subjects together with a group of healthy old individuals and a groups of healthy young adults were recruited in this study. Stress levels were assessed by Perceived Stress Scale (PSS), while depression levels were investigated by Beck Depression Inventories II (BDI-II). Lymphocytes were isolated and assessed by flow cytometry. We observed some age-related changes in lymphocyte subpopulations. In particular, it was evidenced a similar CD4/CD8 ratio between very old subjects and young adults, with this rate being increased in old subjects. A significant increase in the percentage of Natural Killer cells (CD56+CD16+) was observed in the very old subjects, showing that the activity of these cells is well preserved in this group of subjects. Also, we noticed that very old subjects are less stressed, when compared to the other groups. Our data suggests that the combination between increasing and decreasing specific immune functions may generate a balance in the immune system, contributing to reach longevity healthily.O envelhecimento bem sucedido ? caracterizado pela habilidade do sistema imune em manter algumas de suas fun??es intactas, evitando, assim, o aparecimento de doen?as relacionadas ? idade, e, portanto, contribuindo para o alcance da longevidade. Al?m disso, o envelhecimento bem sucedido tamb?m est? relacionado a uma melhor maneira de lidar com o estresse. Diversos estudos v?m demonstrando as altera??es imunol?gicas ocorridas em indiv?duos idosos, assim como as consequ?ncias do estresse para o envelhecimento. No entanto, poucos s?o os estudos que visam observar essas altera??es em indiv?duos longevos. Neste estudo, analisamos fatores ps?quicos e altera??es nos subtipos linfocit?rios envolvidos no envelhecimento e o papel destas altera??es para o alcance da longevidade de maneira saud?vel. Vinte longevos (86-99 anos), 15 idosos (60-80 anos) e 13 jovens adultos saud?veis (20-50 anos) foram recrutados neste estudo. Os n?veis de estresse foram avaliados pela Escala de Estresse Percebido (PSS), enquanto que os n?veis de depress?o foram investigados atrav?s do Invent?rio de Depress?o Beck II (BDI-II). As c?lulas mononucleares de sangue perif?rico foram isoladas e os subtipos linfocit?rios avaliados por citometria de fluxo. Dentre as popula??es avaliadas est?o as c?lulas T CD4+, T CD8+, B CD19+ e c?lulas NK CD56+. Observamos diversas altera??es idade dependente nos subtipos linfocit?rios. Em particular, foi evidenciada uma raz?o CD4/CD8 similar entre longevos e jovens, com um aumento desta raz?o ocorrendo em indiv?duos idosos. Um aumento significativo na percentagem das c?lulas Natural Killers (CD56+CD16+) foi observado nos longevos, sugerindo que a atividade destas c?lulas est? bem preservada nestes indiv?duos. Al?m disso, foi visto que os longevos s?o menos estressados, quando comparados aos outros grupos. Concluindo, nossos resultados sugerem que a combina??o entre o aumento e o decr?scimo de fun??es imunes espec?ficas pode gerar um balan?o no sistema imune, contribuindo para que se alcance a longevidade de forma saud?vel.Made available in DSpace on 2015-04-14T14:51:33Z (GMT). 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dc.title.por.fl_str_mv An?lise de par?metros psiconeuroimunol?gicos em longevos saud?veis
title An?lise de par?metros psiconeuroimunol?gicos em longevos saud?veis
spellingShingle An?lise de par?metros psiconeuroimunol?gicos em longevos saud?veis
Oliveira, ?gatha Schommer de
GERONTOLOGIA BIOM?DICA
BIOLOGIA MOLECULAR
BIOLOGIA CELULAR
IDOSOS
LONGEVIDADE
ENVELHECIMENTO - ASPECTOS BIOL?GICOS
CNPQ::CIENCIAS BIOLOGICAS
title_short An?lise de par?metros psiconeuroimunol?gicos em longevos saud?veis
title_full An?lise de par?metros psiconeuroimunol?gicos em longevos saud?veis
title_fullStr An?lise de par?metros psiconeuroimunol?gicos em longevos saud?veis
title_full_unstemmed An?lise de par?metros psiconeuroimunol?gicos em longevos saud?veis
title_sort An?lise de par?metros psiconeuroimunol?gicos em longevos saud?veis
author Oliveira, ?gatha Schommer de
author_facet Oliveira, ?gatha Schommer de
author_role author
dc.contributor.advisor1.fl_str_mv Bauer, Mois?s Evandro
dc.contributor.advisor1ID.fl_str_mv CPF:65934288091
dc.contributor.advisor1Lattes.fl_str_mv http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4798647T5
dc.contributor.authorID.fl_str_mv CPF:02409139060
dc.contributor.authorLattes.fl_str_mv http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4490307U8
dc.contributor.author.fl_str_mv Oliveira, ?gatha Schommer de
contributor_str_mv Bauer, Mois?s Evandro
dc.subject.por.fl_str_mv GERONTOLOGIA BIOM?DICA
BIOLOGIA MOLECULAR
BIOLOGIA CELULAR
IDOSOS
LONGEVIDADE
ENVELHECIMENTO - ASPECTOS BIOL?GICOS
topic GERONTOLOGIA BIOM?DICA
BIOLOGIA MOLECULAR
BIOLOGIA CELULAR
IDOSOS
LONGEVIDADE
ENVELHECIMENTO - ASPECTOS BIOL?GICOS
CNPQ::CIENCIAS BIOLOGICAS
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS BIOLOGICAS
description Healthy aging is characterized by the ability of the immune system in preserve some of their functions intact, avoiding the appearance of some age-related diseases and thus contributing to reaching longevity. Furthermore, healthy aging is associated to a better stress coping. Studies have demonstrated immunological changes occurred in old individuals, as well as the consequences of stress on aging. However, few studies have addressed such changes in very old subjects. Here, we analyzed emotional factors and the changes in the lymphocytes subpopulations involved on aging, and the role of these changes to reach longevity healthily. A group of twenty healthy very old subjects together with a group of healthy old individuals and a groups of healthy young adults were recruited in this study. Stress levels were assessed by Perceived Stress Scale (PSS), while depression levels were investigated by Beck Depression Inventories II (BDI-II). Lymphocytes were isolated and assessed by flow cytometry. We observed some age-related changes in lymphocyte subpopulations. In particular, it was evidenced a similar CD4/CD8 ratio between very old subjects and young adults, with this rate being increased in old subjects. A significant increase in the percentage of Natural Killer cells (CD56+CD16+) was observed in the very old subjects, showing that the activity of these cells is well preserved in this group of subjects. Also, we noticed that very old subjects are less stressed, when compared to the other groups. Our data suggests that the combination between increasing and decreasing specific immune functions may generate a balance in the immune system, contributing to reach longevity healthily.
publishDate 2014
dc.date.available.fl_str_mv 2014-07-31
dc.date.issued.fl_str_mv 2014-03-25
dc.date.accessioned.fl_str_mv 2015-04-14T14:51:33Z
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dc.identifier.citation.fl_str_mv OLIVEIRA, ?gatha Schommer de. An?lise de par?metros psiconeuroimunol?gicos em longevos saud?veis. 2014. 46 f. Disserta??o (Mestrado em Biologia Celular e Molecular) - Pontif?cia Universidade Cat?lica do Rio Grande do Sul, Porto Alegre, 2014.
dc.identifier.uri.fl_str_mv http://tede2.pucrs.br/tede2/handle/tede/5498
identifier_str_mv OLIVEIRA, ?gatha Schommer de. An?lise de par?metros psiconeuroimunol?gicos em longevos saud?veis. 2014. 46 f. Disserta??o (Mestrado em Biologia Celular e Molecular) - Pontif?cia Universidade Cat?lica do Rio Grande do Sul, Porto Alegre, 2014.
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dc.publisher.department.fl_str_mv Faculdade de Bioci?ncias
publisher.none.fl_str_mv Pontif?cia Universidade Cat?lica do Rio Grande do Sul
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