BRD9 status is a major contributor for cysteine metabolic remodeling through MST and EAAT3 modulation in malignant melanoma

Detalhes bibliográficos
Autor(a) principal: Hipólito, Ana
Data de Publicação: 2024
Outros Autores: Xavier, Renato, Brito, Cheila, Tomás, Ana, Lemos, Isabel, Cabaço, Luís C., Silva, Fernanda, Oliva, Abel, Barral, Duarte C., Vicente, João B., Gonçalves, Luís G., Pojo, Marta, Serpa, Jacinta
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/162409
Resumo: Publisher Copyright: Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
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spelling BRD9 status is a major contributor for cysteine metabolic remodeling through MST and EAAT3 modulation in malignant melanomaBRD9Cutaneous melanomaCysteine metabolismMetabolic remodelingMolecular MedicineMolecular BiologySDG 3 - Good Health and Well-beingPublisher Copyright: Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.Cutaneous melanoma (CM) is the most aggressive skin cancer, showing globally increasing incidence. Hereditary CM accounts for a significant percentage (5-15 %) of all CM cases. However, most familial cases remain without a known genetic cause. Even though, BRD9 has been associated to CM as a susceptibility gene. The molecular events following BRD9 mutagenesis are still not completely understood. In this study, we disclosed BRD9 as a key regulator in cysteine metabolism and associated altered BRD9 to increased cell proliferation, migration and invasiveness, as well as to altered melanin levels, inducing higher susceptibility to melanomagenesis. It is evident that BRD9 WT and mutated BRD9 (c.183G>C) have a different impact on cysteine metabolism, respectively by inhibiting and activating MPST expression in the metastatic A375 cell line. The effect of the mutated BRD9 variant was more evident in A375 cells than in the less invasive WM115 line. Our data point out novel molecular and metabolic mechanisms dependent on BRD9 status that potentially account for the increased risk of developing CM and enhancing CM aggressiveness. Moreover, our findings emphasize the role of cysteine metabolism remodeling in melanoma progression and open new queues to follow to explore the role of BRD9 as a melanoma susceptibility or cancer-related gene.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)iNOVA4Health - pólo NMSInstituto de Tecnologia Química e Biológica António Xavier (ITQB)RUNHipólito, AnaXavier, RenatoBrito, CheilaTomás, AnaLemos, IsabelCabaço, Luís C.Silva, FernandaOliva, AbelBarral, Duarte C.Vicente, João B.Gonçalves, Luís G.Pojo, MartaSerpa, Jacinta2024-01-17T22:27:14Z2024-02-012024-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/162409eng1879-260XPURE: 81028392https://doi.org/10.1016/j.bbadis.2023.166983info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:45:18Zoai:run.unl.pt:10362/162409Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:58:53.429816Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv BRD9 status is a major contributor for cysteine metabolic remodeling through MST and EAAT3 modulation in malignant melanoma
title BRD9 status is a major contributor for cysteine metabolic remodeling through MST and EAAT3 modulation in malignant melanoma
spellingShingle BRD9 status is a major contributor for cysteine metabolic remodeling through MST and EAAT3 modulation in malignant melanoma
Hipólito, Ana
BRD9
Cutaneous melanoma
Cysteine metabolism
Metabolic remodeling
Molecular Medicine
Molecular Biology
SDG 3 - Good Health and Well-being
title_short BRD9 status is a major contributor for cysteine metabolic remodeling through MST and EAAT3 modulation in malignant melanoma
title_full BRD9 status is a major contributor for cysteine metabolic remodeling through MST and EAAT3 modulation in malignant melanoma
title_fullStr BRD9 status is a major contributor for cysteine metabolic remodeling through MST and EAAT3 modulation in malignant melanoma
title_full_unstemmed BRD9 status is a major contributor for cysteine metabolic remodeling through MST and EAAT3 modulation in malignant melanoma
title_sort BRD9 status is a major contributor for cysteine metabolic remodeling through MST and EAAT3 modulation in malignant melanoma
author Hipólito, Ana
author_facet Hipólito, Ana
Xavier, Renato
Brito, Cheila
Tomás, Ana
Lemos, Isabel
Cabaço, Luís C.
Silva, Fernanda
Oliva, Abel
Barral, Duarte C.
Vicente, João B.
Gonçalves, Luís G.
Pojo, Marta
Serpa, Jacinta
author_role author
author2 Xavier, Renato
Brito, Cheila
Tomás, Ana
Lemos, Isabel
Cabaço, Luís C.
Silva, Fernanda
Oliva, Abel
Barral, Duarte C.
Vicente, João B.
Gonçalves, Luís G.
Pojo, Marta
Serpa, Jacinta
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
iNOVA4Health - pólo NMS
Instituto de Tecnologia Química e Biológica António Xavier (ITQB)
RUN
dc.contributor.author.fl_str_mv Hipólito, Ana
Xavier, Renato
Brito, Cheila
Tomás, Ana
Lemos, Isabel
Cabaço, Luís C.
Silva, Fernanda
Oliva, Abel
Barral, Duarte C.
Vicente, João B.
Gonçalves, Luís G.
Pojo, Marta
Serpa, Jacinta
dc.subject.por.fl_str_mv BRD9
Cutaneous melanoma
Cysteine metabolism
Metabolic remodeling
Molecular Medicine
Molecular Biology
SDG 3 - Good Health and Well-being
topic BRD9
Cutaneous melanoma
Cysteine metabolism
Metabolic remodeling
Molecular Medicine
Molecular Biology
SDG 3 - Good Health and Well-being
description Publisher Copyright: Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
publishDate 2024
dc.date.none.fl_str_mv 2024-01-17T22:27:14Z
2024-02-01
2024-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/162409
url http://hdl.handle.net/10362/162409
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1879-260X
PURE: 81028392
https://doi.org/10.1016/j.bbadis.2023.166983
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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