Decompressive surgery in cerebral venous sinus thrombosis due to vaccine‐induced immune thrombotic thrombocytopenia
| Autor(a) principal: | |
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| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/57113 |
Resumo: | © 2023 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Decompressive surgery in cerebral venous sinus thrombosis due to vaccine‐induced immune thrombotic thrombocytopeniaCOVID-19 vaccinationsBrain deathCerebral venous thrombosisComaSurgery© 2023 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.Background and purpose: Cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) is an adverse drug reaction occurring after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. CVST-VITT patients often present with large intracerebral haemorrhages and a high proportion undergoes decompressive surgery. Clinical characteristics, therapeutic management and outcomes of CVST-VITT patients who underwent decompressive surgery are described and predictors of in-hospital mortality in these patients are explored. Methods: Data from an ongoing international registry of patients who developed CVST within 28 days of SARS-CoV-2 vaccination, reported between 29 March 2021 and 10 May 2022, were used. Definite, probable and possible VITT cases, as defined by Pavord et al. (N Engl J Med 2021; 385: 1680-1689), were included. Results: Decompressive surgery was performed in 34/128 (27%) patients with CVST-VITT. In-hospital mortality was 22/34 (65%) in the surgical and 27/94 (29%) in the non-surgical group (p < 0.001). In all surgical cases, the cause of death was brain herniation. The highest mortality rates were found amongst patients with preoperative coma (17/18, 94% vs. 4/14, 29% in the non-comatose; p < 0.001) and bilaterally absent pupillary reflexes (7/7, 100% vs. 6/9, 67% with unilaterally reactive pupil, and 4/11, 36% with bilaterally reactive pupils; p = 0.023). Postoperative imaging revealed worsening of index haemorrhagic lesion in 19 (70%) patients and new haemorrhagic lesions in 16 (59%) patients. At a median follow-up of 6 months, 8/10 of surgical CVST-VITT who survived admission were functionally independent. Conclusions: Almost two-thirds of surgical CVST-VITT patients died during hospital admission. Preoperative coma and bilateral absence of pupillary responses were associated with higher mortality rates. Survivors often achieved functional independence.This research was funded by the Netherlands Organization for Health Research and Development (ZonMw, grant number 10430072110005) and the Dr C.J. Vaillant Foundation.WileyRepositório da Universidade de LisboaKrzywicka, Katarzynade Sousa, Diana AguiarCordonnier, CharlotteBode, Felix J.Field, Thalia S.Michalski, DominikPelz, JohannSkjelland, MonaWiedmann, MarkusZimmermann, JulianWittstock, MatthiasZanotti, BrunoCiccone, AlfonsoBandettini di Poggio, MonicaBorhani‐Haghighi, AfshinChatterton, SophieAujayeb, AvinashDevroye, AnnemieDizonno, VanessaGeeraerts, ThomasGiammello, FabrizioGünther, AlbrechtIchaporia, Nasli R.Kleinig, TimothyKristoffersen, Espen S.Lemmens, RobinDe Maistre, EmmanuelMirzaasgari, ZahraPayen, Jean‐FrancoisPutaala, JukkaPetruzzellis, MarcoRaposo, NicolasSadeghi‐Hokmabadi, ElyarSchoenenberger, SilviaUmaiorubahan, MeenakshisundaramSylaja, Padmavathy Nvan de Munckhof, AnitaSánchez van Kammen, MayteLindgren, ErikJood, KatarinaScutelnic, AdrianHeldner, Mirjam R.Poli, SvenKruip, Marieke J. H. A.Arauz, AntonioConforto, AdrianaAaron, SanjithMiddeldorp, SaskiaTatlisumak, TurgutArnold, MarcelCoutinho, Jonathan M.Ferro, José2023-04-13T14:00:39Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/57113engEur J Neurol. 2023 May;30(5):1335-13451351-510110.1111/ene.157351468-1331info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:05:10Zoai:repositorio.ul.pt:10451/57113Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:07:33.089651Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Decompressive surgery in cerebral venous sinus thrombosis due to vaccine‐induced immune thrombotic thrombocytopenia |
| title |
Decompressive surgery in cerebral venous sinus thrombosis due to vaccine‐induced immune thrombotic thrombocytopenia |
| spellingShingle |
Decompressive surgery in cerebral venous sinus thrombosis due to vaccine‐induced immune thrombotic thrombocytopenia Krzywicka, Katarzyna COVID-19 vaccinations Brain death Cerebral venous thrombosis Coma Surgery |
| title_short |
Decompressive surgery in cerebral venous sinus thrombosis due to vaccine‐induced immune thrombotic thrombocytopenia |
| title_full |
Decompressive surgery in cerebral venous sinus thrombosis due to vaccine‐induced immune thrombotic thrombocytopenia |
| title_fullStr |
Decompressive surgery in cerebral venous sinus thrombosis due to vaccine‐induced immune thrombotic thrombocytopenia |
| title_full_unstemmed |
Decompressive surgery in cerebral venous sinus thrombosis due to vaccine‐induced immune thrombotic thrombocytopenia |
| title_sort |
Decompressive surgery in cerebral venous sinus thrombosis due to vaccine‐induced immune thrombotic thrombocytopenia |
| author |
Krzywicka, Katarzyna |
| author_facet |
Krzywicka, Katarzyna de Sousa, Diana Aguiar Cordonnier, Charlotte Bode, Felix J. Field, Thalia S. Michalski, Dominik Pelz, Johann Skjelland, Mona Wiedmann, Markus Zimmermann, Julian Wittstock, Matthias Zanotti, Bruno Ciccone, Alfonso Bandettini di Poggio, Monica Borhani‐Haghighi, Afshin Chatterton, Sophie Aujayeb, Avinash Devroye, Annemie Dizonno, Vanessa Geeraerts, Thomas Giammello, Fabrizio Günther, Albrecht Ichaporia, Nasli R. Kleinig, Timothy Kristoffersen, Espen S. Lemmens, Robin De Maistre, Emmanuel Mirzaasgari, Zahra Payen, Jean‐Francois Putaala, Jukka Petruzzellis, Marco Raposo, Nicolas Sadeghi‐Hokmabadi, Elyar Schoenenberger, Silvia Umaiorubahan, Meenakshisundaram Sylaja, Padmavathy N van de Munckhof, Anita Sánchez van Kammen, Mayte Lindgren, Erik Jood, Katarina Scutelnic, Adrian Heldner, Mirjam R. Poli, Sven Kruip, Marieke J. H. A. Arauz, Antonio Conforto, Adriana Aaron, Sanjith Middeldorp, Saskia Tatlisumak, Turgut Arnold, Marcel Coutinho, Jonathan M. Ferro, José |
| author_role |
author |
| author2 |
de Sousa, Diana Aguiar Cordonnier, Charlotte Bode, Felix J. Field, Thalia S. Michalski, Dominik Pelz, Johann Skjelland, Mona Wiedmann, Markus Zimmermann, Julian Wittstock, Matthias Zanotti, Bruno Ciccone, Alfonso Bandettini di Poggio, Monica Borhani‐Haghighi, Afshin Chatterton, Sophie Aujayeb, Avinash Devroye, Annemie Dizonno, Vanessa Geeraerts, Thomas Giammello, Fabrizio Günther, Albrecht Ichaporia, Nasli R. Kleinig, Timothy Kristoffersen, Espen S. Lemmens, Robin De Maistre, Emmanuel Mirzaasgari, Zahra Payen, Jean‐Francois Putaala, Jukka Petruzzellis, Marco Raposo, Nicolas Sadeghi‐Hokmabadi, Elyar Schoenenberger, Silvia Umaiorubahan, Meenakshisundaram Sylaja, Padmavathy N van de Munckhof, Anita Sánchez van Kammen, Mayte Lindgren, Erik Jood, Katarina Scutelnic, Adrian Heldner, Mirjam R. Poli, Sven Kruip, Marieke J. H. A. Arauz, Antonio Conforto, Adriana Aaron, Sanjith Middeldorp, Saskia Tatlisumak, Turgut Arnold, Marcel Coutinho, Jonathan M. Ferro, José |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Krzywicka, Katarzyna de Sousa, Diana Aguiar Cordonnier, Charlotte Bode, Felix J. Field, Thalia S. Michalski, Dominik Pelz, Johann Skjelland, Mona Wiedmann, Markus Zimmermann, Julian Wittstock, Matthias Zanotti, Bruno Ciccone, Alfonso Bandettini di Poggio, Monica Borhani‐Haghighi, Afshin Chatterton, Sophie Aujayeb, Avinash Devroye, Annemie Dizonno, Vanessa Geeraerts, Thomas Giammello, Fabrizio Günther, Albrecht Ichaporia, Nasli R. Kleinig, Timothy Kristoffersen, Espen S. Lemmens, Robin De Maistre, Emmanuel Mirzaasgari, Zahra Payen, Jean‐Francois Putaala, Jukka Petruzzellis, Marco Raposo, Nicolas Sadeghi‐Hokmabadi, Elyar Schoenenberger, Silvia Umaiorubahan, Meenakshisundaram Sylaja, Padmavathy N van de Munckhof, Anita Sánchez van Kammen, Mayte Lindgren, Erik Jood, Katarina Scutelnic, Adrian Heldner, Mirjam R. Poli, Sven Kruip, Marieke J. H. A. Arauz, Antonio Conforto, Adriana Aaron, Sanjith Middeldorp, Saskia Tatlisumak, Turgut Arnold, Marcel Coutinho, Jonathan M. Ferro, José |
| dc.subject.por.fl_str_mv |
COVID-19 vaccinations Brain death Cerebral venous thrombosis Coma Surgery |
| topic |
COVID-19 vaccinations Brain death Cerebral venous thrombosis Coma Surgery |
| description |
© 2023 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-04-13T14:00:39Z 2023 2023-01-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/57113 |
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http://hdl.handle.net/10451/57113 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Eur J Neurol. 2023 May;30(5):1335-1345 1351-5101 10.1111/ene.15735 1468-1331 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Wiley |
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Wiley |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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