Synthesis and Characterization of Heparin-Doped Polypyrrole Coatings Using an Electrochemical Quartz Crystal Microbalance (EQCM)

Detalhes bibliográficos
Autor(a) principal: Flamini,D. O.
Data de Publicação: 2022
Outros Autores: González,M. B., Saidman,S. B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042022000100047
Resumo: Abstract Polypyrrole (PPy) films were electrochemically synthesized on an Au/TiO2 coated quartz crystal electrode in solutions with different heparin (Hep) concentrations. The PPy films morphology was determined by tapping a mode atomic force microscopy (AFM). The influence of the dopant concentration on the coating surface roughness was studied. Electrochemical quartz crystal microbalance (EQCM) results suggest that Hep retained in the PPy films was bound to thrombin. The adsorbed thrombin amount increased with a higher coating surface roughness. PPy films doped with Hep are electroactive and show cation exchange properties under oxidation or reduction conditions in a Ringer solution. The pre-oxidized PPy film adsorbed a greater thrombin amount than the freshly one and even more than the pre-reduced film.
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spelling Synthesis and Characterization of Heparin-Doped Polypyrrole Coatings Using an Electrochemical Quartz Crystal Microbalance (EQCM)EQCMPolypyrroleHeparin and ThrombinAbstract Polypyrrole (PPy) films were electrochemically synthesized on an Au/TiO2 coated quartz crystal electrode in solutions with different heparin (Hep) concentrations. The PPy films morphology was determined by tapping a mode atomic force microscopy (AFM). The influence of the dopant concentration on the coating surface roughness was studied. Electrochemical quartz crystal microbalance (EQCM) results suggest that Hep retained in the PPy films was bound to thrombin. The adsorbed thrombin amount increased with a higher coating surface roughness. PPy films doped with Hep are electroactive and show cation exchange properties under oxidation or reduction conditions in a Ringer solution. The pre-oxidized PPy film adsorbed a greater thrombin amount than the freshly one and even more than the pre-reduced film.Sociedade Portuguesa de Electroquímica2022-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042022000100047Portugaliae Electrochimica Acta v.40 n.1 2022reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042022000100047Flamini,D. O.González,M. B.Saidman,S. B.info:eu-repo/semantics/openAccess2024-02-06T17:07:36Zoai:scielo:S0872-19042022000100047Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:20:28.602723Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Synthesis and Characterization of Heparin-Doped Polypyrrole Coatings Using an Electrochemical Quartz Crystal Microbalance (EQCM)
title Synthesis and Characterization of Heparin-Doped Polypyrrole Coatings Using an Electrochemical Quartz Crystal Microbalance (EQCM)
spellingShingle Synthesis and Characterization of Heparin-Doped Polypyrrole Coatings Using an Electrochemical Quartz Crystal Microbalance (EQCM)
Flamini,D. O.
EQCM
Polypyrrole
Heparin and Thrombin
title_short Synthesis and Characterization of Heparin-Doped Polypyrrole Coatings Using an Electrochemical Quartz Crystal Microbalance (EQCM)
title_full Synthesis and Characterization of Heparin-Doped Polypyrrole Coatings Using an Electrochemical Quartz Crystal Microbalance (EQCM)
title_fullStr Synthesis and Characterization of Heparin-Doped Polypyrrole Coatings Using an Electrochemical Quartz Crystal Microbalance (EQCM)
title_full_unstemmed Synthesis and Characterization of Heparin-Doped Polypyrrole Coatings Using an Electrochemical Quartz Crystal Microbalance (EQCM)
title_sort Synthesis and Characterization of Heparin-Doped Polypyrrole Coatings Using an Electrochemical Quartz Crystal Microbalance (EQCM)
author Flamini,D. O.
author_facet Flamini,D. O.
González,M. B.
Saidman,S. B.
author_role author
author2 González,M. B.
Saidman,S. B.
author2_role author
author
dc.contributor.author.fl_str_mv Flamini,D. O.
González,M. B.
Saidman,S. B.
dc.subject.por.fl_str_mv EQCM
Polypyrrole
Heparin and Thrombin
topic EQCM
Polypyrrole
Heparin and Thrombin
description Abstract Polypyrrole (PPy) films were electrochemically synthesized on an Au/TiO2 coated quartz crystal electrode in solutions with different heparin (Hep) concentrations. The PPy films morphology was determined by tapping a mode atomic force microscopy (AFM). The influence of the dopant concentration on the coating surface roughness was studied. Electrochemical quartz crystal microbalance (EQCM) results suggest that Hep retained in the PPy films was bound to thrombin. The adsorbed thrombin amount increased with a higher coating surface roughness. PPy films doped with Hep are electroactive and show cation exchange properties under oxidation or reduction conditions in a Ringer solution. The pre-oxidized PPy film adsorbed a greater thrombin amount than the freshly one and even more than the pre-reduced film.
publishDate 2022
dc.date.none.fl_str_mv 2022-02-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042022000100047
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042022000100047
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042022000100047
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Electroquímica
publisher.none.fl_str_mv Sociedade Portuguesa de Electroquímica
dc.source.none.fl_str_mv Portugaliae Electrochimica Acta v.40 n.1 2022
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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