Gene Association with Leprosy: A Review of Published Data
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/108601 https://doi.org/10.3389/fimmu.2015.00658 |
Resumo: | Leprosy is a chronic infectious disease caused by an obligate intracellular bacterium known as Mycobacterium leprae. Exposure to the bacillus is necessary, but this alone does not mean an individual will develop clinical symptoms of the disease. In recent years, several genes have been associated with leprosy and the innate immune response pathways converge on the main hypothesis that genes are involved in the susceptibility for the disease in two distinct steps: for leprosy per se and in the development of the different clinical forms. These genes participate in the sensing, main metabolic pathway of immune response activation and, subsequently, on the evolution of the disease into its clinical forms. The aim of this review is to highlight the role of innate immune response in the context of leprosy, stressing their participation in the signaling and targeting processes in response to bacillus infection and on the evolution to the clinical forms of the disease. |
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Gene Association with Leprosy: A Review of Published Dataleprosyinnate immunityimmune response genesMycobacterium lepraeLeprosy is a chronic infectious disease caused by an obligate intracellular bacterium known as Mycobacterium leprae. Exposure to the bacillus is necessary, but this alone does not mean an individual will develop clinical symptoms of the disease. In recent years, several genes have been associated with leprosy and the innate immune response pathways converge on the main hypothesis that genes are involved in the susceptibility for the disease in two distinct steps: for leprosy per se and in the development of the different clinical forms. These genes participate in the sensing, main metabolic pathway of immune response activation and, subsequently, on the evolution of the disease into its clinical forms. The aim of this review is to highlight the role of innate immune response in the context of leprosy, stressing their participation in the signaling and targeting processes in response to bacillus infection and on the evolution to the clinical forms of the disease.Frontiers Media S.A.2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/108601http://hdl.handle.net/10316/108601https://doi.org/10.3389/fimmu.2015.00658eng1664-3224Mazini, Priscila SaamaraAlves, Hugo VicentinReis, Pâmela GuimarãesLopes, Ana PaulaSell, Ana MariaSantos-Rosa, ManuelVisentainer, Jeane Eliete LaguilaRodrigues-Santos, Pauloinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-05T08:28:45Zoai:estudogeral.uc.pt:10316/108601Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:24:53.587951Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Gene Association with Leprosy: A Review of Published Data |
title |
Gene Association with Leprosy: A Review of Published Data |
spellingShingle |
Gene Association with Leprosy: A Review of Published Data Mazini, Priscila Saamara leprosy innate immunity immune response genes Mycobacterium leprae |
title_short |
Gene Association with Leprosy: A Review of Published Data |
title_full |
Gene Association with Leprosy: A Review of Published Data |
title_fullStr |
Gene Association with Leprosy: A Review of Published Data |
title_full_unstemmed |
Gene Association with Leprosy: A Review of Published Data |
title_sort |
Gene Association with Leprosy: A Review of Published Data |
author |
Mazini, Priscila Saamara |
author_facet |
Mazini, Priscila Saamara Alves, Hugo Vicentin Reis, Pâmela Guimarães Lopes, Ana Paula Sell, Ana Maria Santos-Rosa, Manuel Visentainer, Jeane Eliete Laguila Rodrigues-Santos, Paulo |
author_role |
author |
author2 |
Alves, Hugo Vicentin Reis, Pâmela Guimarães Lopes, Ana Paula Sell, Ana Maria Santos-Rosa, Manuel Visentainer, Jeane Eliete Laguila Rodrigues-Santos, Paulo |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Mazini, Priscila Saamara Alves, Hugo Vicentin Reis, Pâmela Guimarães Lopes, Ana Paula Sell, Ana Maria Santos-Rosa, Manuel Visentainer, Jeane Eliete Laguila Rodrigues-Santos, Paulo |
dc.subject.por.fl_str_mv |
leprosy innate immunity immune response genes Mycobacterium leprae |
topic |
leprosy innate immunity immune response genes Mycobacterium leprae |
description |
Leprosy is a chronic infectious disease caused by an obligate intracellular bacterium known as Mycobacterium leprae. Exposure to the bacillus is necessary, but this alone does not mean an individual will develop clinical symptoms of the disease. In recent years, several genes have been associated with leprosy and the innate immune response pathways converge on the main hypothesis that genes are involved in the susceptibility for the disease in two distinct steps: for leprosy per se and in the development of the different clinical forms. These genes participate in the sensing, main metabolic pathway of immune response activation and, subsequently, on the evolution of the disease into its clinical forms. The aim of this review is to highlight the role of innate immune response in the context of leprosy, stressing their participation in the signaling and targeting processes in response to bacillus infection and on the evolution to the clinical forms of the disease. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/108601 http://hdl.handle.net/10316/108601 https://doi.org/10.3389/fimmu.2015.00658 |
url |
http://hdl.handle.net/10316/108601 https://doi.org/10.3389/fimmu.2015.00658 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1664-3224 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Frontiers Media S.A. |
publisher.none.fl_str_mv |
Frontiers Media S.A. |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134132171702272 |