Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/62319 |
Resumo: | The laterodorsal tegmentum (LDT) is associated with reward considering that it modulates VTA neuronal activity, but recent anatomical evidence shows that the LDT also directly projects to nucleus accumbens (NAc). We show that the majority of LDT-NAc inputs are cholinergic, but there is also GABAergic and glutamatergic innervation; activation of LDT induces a predominantly excitatory response in the NAc. Non-selective optogenetic activation of LDT-NAc projections in rats enhances motivational drive and shifts preference to an otherwise equal reward; whereas inhibition of these projections induces the opposite. Activation of these projections also induces robust place preference. In mice, specific activation of LDT-NAc cholinergic inputs (but not glutamatergic or GABAergic) is sufficient to shift preference, increase motivation, and drive positive reinforcement in different behavioral paradigms. These results provide evidence that LDT-NAc projections play an important role in motivated behaviors and positive reinforcement, and that distinct neuronal populations differentially contribute for these behaviors. |
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Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviorsCiências Médicas::Medicina BásicaScience & TechnologyThe laterodorsal tegmentum (LDT) is associated with reward considering that it modulates VTA neuronal activity, but recent anatomical evidence shows that the LDT also directly projects to nucleus accumbens (NAc). We show that the majority of LDT-NAc inputs are cholinergic, but there is also GABAergic and glutamatergic innervation; activation of LDT induces a predominantly excitatory response in the NAc. Non-selective optogenetic activation of LDT-NAc projections in rats enhances motivational drive and shifts preference to an otherwise equal reward; whereas inhibition of these projections induces the opposite. Activation of these projections also induces robust place preference. In mice, specific activation of LDT-NAc cholinergic inputs (but not glutamatergic or GABAergic) is sufficient to shift preference, increase motivation, and drive positive reinforcement in different behavioral paradigms. These results provide evidence that LDT-NAc projections play an important role in motivated behaviors and positive reinforcement, and that distinct neuronal populations differentially contribute for these behaviors.BIAL Foundation Grant (PT/FB/BL-2016-030). Part of the work was supported by FCT project PTDC/MED-NEU/29071/2017. This project is in the scope of the project NORTE-01-0145-FEDER-000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER). Part of this work has also been funded by FEDER funds, through the Competitiveness Factors Operational Programme (COMPETE), and by National funds, through the Foundation for Science and Technology (FCT), under the scope of the project POCI-01-0145-FEDER-007038Nature ResearchUniversidade do MinhoCoimbra, BárbaraSoares-Cunha, CarinaVasconcelos, Nivaldo António PortelaDomingues, Ana VerónicaBorges, SóniaSousa, NunoRodrigues, Ana João2019-09-122019-09-12T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/62319engCoimbra, B., Soares-Cunha, C., Vasconcelos, N. A., Domingues, A. V., Borges, S., Sousa, N., & Rodrigues, A. J. (2019). Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors. Nature communications, 10(1), 1-15.2041-17232041-172310.1038/s41467-019-11557-331515512https://www.nature.com/articles/s41467-019-11557-3#citeasinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:56:18Zoai:repositorium.sdum.uminho.pt:1822/62319Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:45:55.978886Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors |
title |
Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors |
spellingShingle |
Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors Coimbra, Bárbara Ciências Médicas::Medicina Básica Science & Technology |
title_short |
Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors |
title_full |
Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors |
title_fullStr |
Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors |
title_full_unstemmed |
Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors |
title_sort |
Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors |
author |
Coimbra, Bárbara |
author_facet |
Coimbra, Bárbara Soares-Cunha, Carina Vasconcelos, Nivaldo António Portela Domingues, Ana Verónica Borges, Sónia Sousa, Nuno Rodrigues, Ana João |
author_role |
author |
author2 |
Soares-Cunha, Carina Vasconcelos, Nivaldo António Portela Domingues, Ana Verónica Borges, Sónia Sousa, Nuno Rodrigues, Ana João |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Coimbra, Bárbara Soares-Cunha, Carina Vasconcelos, Nivaldo António Portela Domingues, Ana Verónica Borges, Sónia Sousa, Nuno Rodrigues, Ana João |
dc.subject.por.fl_str_mv |
Ciências Médicas::Medicina Básica Science & Technology |
topic |
Ciências Médicas::Medicina Básica Science & Technology |
description |
The laterodorsal tegmentum (LDT) is associated with reward considering that it modulates VTA neuronal activity, but recent anatomical evidence shows that the LDT also directly projects to nucleus accumbens (NAc). We show that the majority of LDT-NAc inputs are cholinergic, but there is also GABAergic and glutamatergic innervation; activation of LDT induces a predominantly excitatory response in the NAc. Non-selective optogenetic activation of LDT-NAc projections in rats enhances motivational drive and shifts preference to an otherwise equal reward; whereas inhibition of these projections induces the opposite. Activation of these projections also induces robust place preference. In mice, specific activation of LDT-NAc cholinergic inputs (but not glutamatergic or GABAergic) is sufficient to shift preference, increase motivation, and drive positive reinforcement in different behavioral paradigms. These results provide evidence that LDT-NAc projections play an important role in motivated behaviors and positive reinforcement, and that distinct neuronal populations differentially contribute for these behaviors. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-09-12 2019-09-12T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/62319 |
url |
http://hdl.handle.net/1822/62319 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Coimbra, B., Soares-Cunha, C., Vasconcelos, N. A., Domingues, A. V., Borges, S., Sousa, N., & Rodrigues, A. J. (2019). Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors. Nature communications, 10(1), 1-15. 2041-1723 2041-1723 10.1038/s41467-019-11557-3 31515512 https://www.nature.com/articles/s41467-019-11557-3#citeas |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Nature Research |
publisher.none.fl_str_mv |
Nature Research |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132213996945408 |