Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.8/8421 |
Resumo: | The authors thank Bioceramed S.A. for providing the materials used in the present study and Fundação para a Ciência e Tecnologia (FCT) for the PhD grant SFRH/BD/51949/2012. Funding received from FCT (UID/BIO/04565/2019), from Programa Operacional Regional de Lisboa 2020 (Project N. 007317) and PAC (Project 016394) is also acknowledged. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applicationsBioabsorbable polymersChitosanPlasticizersCeramicsMechanical propertiesMicrostructureThe authors thank Bioceramed S.A. for providing the materials used in the present study and Fundação para a Ciência e Tecnologia (FCT) for the PhD grant SFRH/BD/51949/2012. Funding received from FCT (UID/BIO/04565/2019), from Programa Operacional Regional de Lisboa 2020 (Project N. 007317) and PAC (Project 016394) is also acknowledged.Bioabsorbable polymeric fixation devices have been used as an alternative to metallic implants in orthopedics,preventing the stress shielding effect and avoiding a second surgery for implant removal. However,several problems are still associated with current bioabsorbable implants, including the limited mechanical stiffness and strength, and the adverse tissue reactions generated. To minimize or even eliminate the problems associated with these implants, strategies have been developed to synthesize new implant materials based on chitosan. To overcome the brittle behavior of most 3D chitosan-based structures, glycerol and sorbitol were blended to chitosan and the effect of these plasticizers in the produced specimens was analyzed by flexural tests, Berkovich tests, scanning electron microscopy (SEM) and micro-CT analyzes. The improvement of the mechanical properties was also tested by adding ceramics, namely hydroxyapatite powder and biphasic mixtures of hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP). In the plasticizers group, the best combination of the measured properties was obtained for chitosan with 10% glycerol (flexural strength of 53.8 MPa and indentation hardness of 19.4 kgf/mm2), while in the ceramics group the best mechanical behavior was obtained for chitosan with 10% HAþβ-TCP powder (flexural strength of 67.5 MPa and indentation hardness 28.2 kgf/mm2). All the tested material compositions were dense and homogeneous, fundamental condition for a good implant performance. These are encouraging results, which support the continued development of chitosan-based materials for orthopedic fixation applications.ElsevierIC-OnlineFigueiredo, LígiaFonseca, RitaPinto, Luís F. V.Ferreira, Frederico CasteloAlmeida, AméliaRodrigues, Alexandra2023-04-19T14:56:31Z2020-032020-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/8421engFigueiredo, L., Fonseca, R., Pinto, L. F. V., Ferreira, F. C., Almeida, A., & Rodrigues, A. (2020). Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications. Journal of the Mechanical Behavior of Biomedical Materials, 103. https://doi.org/10.1016/j.jmbbm.2019.1035721751-616110.1016/j.jmbbm.2019.103572metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:57:17Zoai:iconline.ipleiria.pt:10400.8/8421Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:51:08.868356Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications |
title |
Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications |
spellingShingle |
Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications Figueiredo, Lígia Bioabsorbable polymers Chitosan Plasticizers Ceramics Mechanical properties Microstructure |
title_short |
Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications |
title_full |
Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications |
title_fullStr |
Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications |
title_full_unstemmed |
Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications |
title_sort |
Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications |
author |
Figueiredo, Lígia |
author_facet |
Figueiredo, Lígia Fonseca, Rita Pinto, Luís F. V. Ferreira, Frederico Castelo Almeida, Amélia Rodrigues, Alexandra |
author_role |
author |
author2 |
Fonseca, Rita Pinto, Luís F. V. Ferreira, Frederico Castelo Almeida, Amélia Rodrigues, Alexandra |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
IC-Online |
dc.contributor.author.fl_str_mv |
Figueiredo, Lígia Fonseca, Rita Pinto, Luís F. V. Ferreira, Frederico Castelo Almeida, Amélia Rodrigues, Alexandra |
dc.subject.por.fl_str_mv |
Bioabsorbable polymers Chitosan Plasticizers Ceramics Mechanical properties Microstructure |
topic |
Bioabsorbable polymers Chitosan Plasticizers Ceramics Mechanical properties Microstructure |
description |
The authors thank Bioceramed S.A. for providing the materials used in the present study and Fundação para a Ciência e Tecnologia (FCT) for the PhD grant SFRH/BD/51949/2012. Funding received from FCT (UID/BIO/04565/2019), from Programa Operacional Regional de Lisboa 2020 (Project N. 007317) and PAC (Project 016394) is also acknowledged. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-03 2020-03-01T00:00:00Z 2023-04-19T14:56:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.8/8421 |
url |
http://hdl.handle.net/10400.8/8421 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Figueiredo, L., Fonseca, R., Pinto, L. F. V., Ferreira, F. C., Almeida, A., & Rodrigues, A. (2020). Strategy to improve the mechanical properties of bioabsorbable materials based on chitosan for orthopedic fixation applications. Journal of the Mechanical Behavior of Biomedical Materials, 103. https://doi.org/10.1016/j.jmbbm.2019.103572 1751-6161 10.1016/j.jmbbm.2019.103572 |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799137002942103552 |