25 Anos de Sida: história de uma pandemia: em memória de José Luís Champalimaud
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/4429 |
Resumo: | Twenty five years after the report of the first cases of HIV/AIDS we can consider that the evolution of this pandemic registered several successes but also significant failures. During the first 15 years of the pandemic, etiologic agent was identified, diagnostic tests were developed and the first antiretrovirals were available. During this period we could verify that the use of zidovudine had a prophylactic effect on the vertical transmission and that some drugs could prevent several opportunistic infections. However, the morbidity and the mortality associated to the infection continued to be very significant and AIDS was considered a fatal disease. Only in 1996 with the development of HAART (highly active antiretroviral therapy) AIDS became a chronic disease. The use of protease inhibitors and, later, of non-nucleoside reverse transcriptase inhibitors, the development of resistance assays and the capacity to quantify the viral load and of dosing the plasmatic concentration of the antiretrovirals, were important tools to change the course of this infection. Nevertheless, in 2007, HIV continues to resist to the efforts to find a cure or a vaccine and HIV continues to spread particularly in the poorest countries of the World and infected until now 65 millions of persons of which 25 millions died. |
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25 Anos de Sida: história de uma pandemia: em memória de José Luís ChampalimaudAIDSHistorical aspectsAntiretroviral therapyTwenty five years after the report of the first cases of HIV/AIDS we can consider that the evolution of this pandemic registered several successes but also significant failures. During the first 15 years of the pandemic, etiologic agent was identified, diagnostic tests were developed and the first antiretrovirals were available. During this period we could verify that the use of zidovudine had a prophylactic effect on the vertical transmission and that some drugs could prevent several opportunistic infections. However, the morbidity and the mortality associated to the infection continued to be very significant and AIDS was considered a fatal disease. Only in 1996 with the development of HAART (highly active antiretroviral therapy) AIDS became a chronic disease. The use of protease inhibitors and, later, of non-nucleoside reverse transcriptase inhibitors, the development of resistance assays and the capacity to quantify the viral load and of dosing the plasmatic concentration of the antiretrovirals, were important tools to change the course of this infection. Nevertheless, in 2007, HIV continues to resist to the efforts to find a cure or a vaccine and HIV continues to spread particularly in the poorest countries of the World and infected until now 65 millions of persons of which 25 millions died.Sociedade Portuguesa de Doenças Infecciosas e Microbiologia Clinica.Veritati - Repositório Institucional da Universidade Católica PortuguesaCastro, R. Sarmento eLecour, Henrique2011-06-09T10:36:03Z20072007-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/4429porLECOUR, Henrique; SARMENTO E CASTRO, R. - 25 Anos de Sida: história de uma pandemia: em memória de José Luís Champalimaud. Revista Portuguesa de Doencas Infecciosas. ISSN 1646-3633. Vol. 3, nº 2 (2007), p. 63-70info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-12T17:10:29Zoai:repositorio.ucp.pt:10400.14/4429Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:05:45.647273Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
25 Anos de Sida: história de uma pandemia: em memória de José Luís Champalimaud |
title |
25 Anos de Sida: história de uma pandemia: em memória de José Luís Champalimaud |
spellingShingle |
25 Anos de Sida: história de uma pandemia: em memória de José Luís Champalimaud Castro, R. Sarmento e AIDS Historical aspects Antiretroviral therapy |
title_short |
25 Anos de Sida: história de uma pandemia: em memória de José Luís Champalimaud |
title_full |
25 Anos de Sida: história de uma pandemia: em memória de José Luís Champalimaud |
title_fullStr |
25 Anos de Sida: história de uma pandemia: em memória de José Luís Champalimaud |
title_full_unstemmed |
25 Anos de Sida: história de uma pandemia: em memória de José Luís Champalimaud |
title_sort |
25 Anos de Sida: história de uma pandemia: em memória de José Luís Champalimaud |
author |
Castro, R. Sarmento e |
author_facet |
Castro, R. Sarmento e Lecour, Henrique |
author_role |
author |
author2 |
Lecour, Henrique |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Castro, R. Sarmento e Lecour, Henrique |
dc.subject.por.fl_str_mv |
AIDS Historical aspects Antiretroviral therapy |
topic |
AIDS Historical aspects Antiretroviral therapy |
description |
Twenty five years after the report of the first cases of HIV/AIDS we can consider that the evolution of this pandemic registered several successes but also significant failures. During the first 15 years of the pandemic, etiologic agent was identified, diagnostic tests were developed and the first antiretrovirals were available. During this period we could verify that the use of zidovudine had a prophylactic effect on the vertical transmission and that some drugs could prevent several opportunistic infections. However, the morbidity and the mortality associated to the infection continued to be very significant and AIDS was considered a fatal disease. Only in 1996 with the development of HAART (highly active antiretroviral therapy) AIDS became a chronic disease. The use of protease inhibitors and, later, of non-nucleoside reverse transcriptase inhibitors, the development of resistance assays and the capacity to quantify the viral load and of dosing the plasmatic concentration of the antiretrovirals, were important tools to change the course of this infection. Nevertheless, in 2007, HIV continues to resist to the efforts to find a cure or a vaccine and HIV continues to spread particularly in the poorest countries of the World and infected until now 65 millions of persons of which 25 millions died. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007 2007-01-01T00:00:00Z 2011-06-09T10:36:03Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/4429 |
url |
http://hdl.handle.net/10400.14/4429 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
LECOUR, Henrique; SARMENTO E CASTRO, R. - 25 Anos de Sida: história de uma pandemia: em memória de José Luís Champalimaud. Revista Portuguesa de Doencas Infecciosas. ISSN 1646-3633. Vol. 3, nº 2 (2007), p. 63-70 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Doenças Infecciosas e Microbiologia Clinica. |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Doenças Infecciosas e Microbiologia Clinica. |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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