Regeneration of starfish radial nerve cord restores animal mobility and unveils a new coelomocyte population
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/158528 |
Resumo: | Publisher Copyright: © 2023, The Author(s). |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Regeneration of starfish radial nerve cord restores animal mobility and unveils a new coelomocyte populationCoelomocytesEchinodermFlow cytometry/imaging flow cytometryMarthasterias glacialisNerve regenerationPathology and Forensic MedicineHistologyCell BiologyPublisher Copyright: © 2023, The Author(s).The potential to regenerate a damaged body part is expressed to a different extent in animals. Echinoderms, in particular starfish, are known for their outstanding regenerating potential. Differently, humans have restricted abilities to restore organ systems being dependent on limited sources of stem cells. In particular, the potential to regenerate the central nervous system is extremely limited, explaining the lack of natural mechanisms that could overcome the development of neurodegenerative diseases and the occurrence of trauma. Therefore, understanding the molecular and cellular mechanisms of regeneration in starfish could help the development of new therapeutic approaches in humans. In this study, we tackle the problem of starfish central nervous system regeneration by examining the external and internal anatomical and behavioral traits, the dynamics of coelomocyte populations, and neuronal tissue architecture after radial nerve cord (RNC) partial ablation. We noticed that the removal of part of RNC generated several anatomic anomalies and induced behavioral modifications (injured arm could not be used anymore to lead the starfish movement). Those alterations seem to be related to defense mechanisms and protection of the wound. In particular, histology showed that tissue patterns during regeneration resemble those described in holothurians and in starfish arm tip regeneration. Flow cytometry coupled with imaging flow cytometry unveiled a new coelomocyte population during the late phase of the regeneration process. Morphotypes of these and previously characterized coelomocyte populations were described based on IFC data. Further studies of this new coelomocyte population might provide insights on their involvement in radial nerve cord regeneration.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Instituto de Tecnologia Química e Biológica António Xavier (ITQB)RUNMagalhães, FilipeAndrade, ClaúdiaSimões, BeatrizBrigham, FrediValente, RubenMartinez, PedroRino, JoséSugni, MichelaCoelho, Ana Varela2023-09-30T22:19:02Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/158528eng0302-766XPURE: 72374643https://doi.org/10.1007/s00441-023-03818-xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:41:00Zoai:run.unl.pt:10362/158528Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:11.452535Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Regeneration of starfish radial nerve cord restores animal mobility and unveils a new coelomocyte population |
| title |
Regeneration of starfish radial nerve cord restores animal mobility and unveils a new coelomocyte population |
| spellingShingle |
Regeneration of starfish radial nerve cord restores animal mobility and unveils a new coelomocyte population Magalhães, Filipe Coelomocytes Echinoderm Flow cytometry/imaging flow cytometry Marthasterias glacialis Nerve regeneration Pathology and Forensic Medicine Histology Cell Biology |
| title_short |
Regeneration of starfish radial nerve cord restores animal mobility and unveils a new coelomocyte population |
| title_full |
Regeneration of starfish radial nerve cord restores animal mobility and unveils a new coelomocyte population |
| title_fullStr |
Regeneration of starfish radial nerve cord restores animal mobility and unveils a new coelomocyte population |
| title_full_unstemmed |
Regeneration of starfish radial nerve cord restores animal mobility and unveils a new coelomocyte population |
| title_sort |
Regeneration of starfish radial nerve cord restores animal mobility and unveils a new coelomocyte population |
| author |
Magalhães, Filipe |
| author_facet |
Magalhães, Filipe Andrade, Claúdia Simões, Beatriz Brigham, Fredi Valente, Ruben Martinez, Pedro Rino, José Sugni, Michela Coelho, Ana Varela |
| author_role |
author |
| author2 |
Andrade, Claúdia Simões, Beatriz Brigham, Fredi Valente, Ruben Martinez, Pedro Rino, José Sugni, Michela Coelho, Ana Varela |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Instituto de Tecnologia Química e Biológica António Xavier (ITQB) RUN |
| dc.contributor.author.fl_str_mv |
Magalhães, Filipe Andrade, Claúdia Simões, Beatriz Brigham, Fredi Valente, Ruben Martinez, Pedro Rino, José Sugni, Michela Coelho, Ana Varela |
| dc.subject.por.fl_str_mv |
Coelomocytes Echinoderm Flow cytometry/imaging flow cytometry Marthasterias glacialis Nerve regeneration Pathology and Forensic Medicine Histology Cell Biology |
| topic |
Coelomocytes Echinoderm Flow cytometry/imaging flow cytometry Marthasterias glacialis Nerve regeneration Pathology and Forensic Medicine Histology Cell Biology |
| description |
Publisher Copyright: © 2023, The Author(s). |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-09-30T22:19:02Z 2023 2023-01-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/158528 |
| url |
http://hdl.handle.net/10362/158528 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
0302-766X PURE: 72374643 https://doi.org/10.1007/s00441-023-03818-x |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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