The Protective Role of HLA-DRB1(*)13 in Autoimmune Diseases
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/3282 |
Resumo: | Autoimmune diseases (AIDs) are characterized by a multifactorial aetiology and a complex genetic background, with the MHC region playing a major role. We genotyped for HLA-DRB1 locus 1228 patients with AIDs-213 with Systemic Lupus Erythematosus (SLE), 166 with Psoriasis or Psoriatic Arthritis (Ps + PsA), 153 with Rheumatoid Arthritis (RA), 67 with Systemic Sclerosis (SSc), 536 with Multiple Sclerosis (MS), and 93 with Myasthenia Gravis (MG) and 282 unrelated controls. We confirmed previously established associations of HLA-DRB1(∗)15 (OR = 2.17) and HLA-DRB1(∗)03 (OR = 1.81) alleles with MS, HLA-DRB1(∗)03 with SLE (OR = 2.49), HLA-DRB1(∗)01 (OR = 1.79) and HLA-DRB1(∗)04 (OR = 2.81) with RA, HLA-DRB1(∗)07 with Ps + PsA (OR = 1.79), HLA-DRB1(∗)01 (OR = 2.28) and HLA-DRB1(∗)08 (OR = 3.01) with SSc, and HLA-DRB1(∗)03 with MG (OR = 2.98). We further observed a consistent negative association of HLA-DRB1(∗)13 allele with SLE, Ps + PsA, RA, and SSc (18.3%, 19.3%, 16.3%, and 11.9%, resp., versus 29.8% in controls). HLA-DRB1(∗)13 frequency in the AIDs group was 20.0% (OR = 0.58). Although different alleles were associated with particular AIDs, the same allele, HLA-DRB1(∗)13, was underrepresented in all of the six diseases analysed. This observation suggests that this allele may confer protection for AIDs, particularly for systemic and rheumatic disease. The protective effect of HLA-DRB1(∗)13 could be explained by a more proficient antigen presentation by these molecules, favouring efficient clonal deletion during thymic selection. |
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The Protective Role of HLA-DRB1(*)13 in Autoimmune DiseasesDermatology and VenerologyClinical GeneticsInternal MedicineRheumatologyMicrobiologyimmunologyAutoimmune DiseasesHLAImmunogeneticsClinical immunologyDoenças GenéticasDeterminantes da Saúde e da DoençaAutoimmune diseases (AIDs) are characterized by a multifactorial aetiology and a complex genetic background, with the MHC region playing a major role. We genotyped for HLA-DRB1 locus 1228 patients with AIDs-213 with Systemic Lupus Erythematosus (SLE), 166 with Psoriasis or Psoriatic Arthritis (Ps + PsA), 153 with Rheumatoid Arthritis (RA), 67 with Systemic Sclerosis (SSc), 536 with Multiple Sclerosis (MS), and 93 with Myasthenia Gravis (MG) and 282 unrelated controls. We confirmed previously established associations of HLA-DRB1(∗)15 (OR = 2.17) and HLA-DRB1(∗)03 (OR = 1.81) alleles with MS, HLA-DRB1(∗)03 with SLE (OR = 2.49), HLA-DRB1(∗)01 (OR = 1.79) and HLA-DRB1(∗)04 (OR = 2.81) with RA, HLA-DRB1(∗)07 with Ps + PsA (OR = 1.79), HLA-DRB1(∗)01 (OR = 2.28) and HLA-DRB1(∗)08 (OR = 3.01) with SSc, and HLA-DRB1(∗)03 with MG (OR = 2.98). We further observed a consistent negative association of HLA-DRB1(∗)13 allele with SLE, Ps + PsA, RA, and SSc (18.3%, 19.3%, 16.3%, and 11.9%, resp., versus 29.8% in controls). HLA-DRB1(∗)13 frequency in the AIDs group was 20.0% (OR = 0.58). Although different alleles were associated with particular AIDs, the same allele, HLA-DRB1(∗)13, was underrepresented in all of the six diseases analysed. This observation suggests that this allele may confer protection for AIDs, particularly for systemic and rheumatic disease. The protective effect of HLA-DRB1(∗)13 could be explained by a more proficient antigen presentation by these molecules, favouring efficient clonal deletion during thymic selection.Hindawi Publishing CorporationRepositório Científico do Instituto Nacional de SaúdeBettencourt, AndreiaCarvalho, CláudiaLeal, BárbaraBrás, SandraLopes, DinaMartins da Silva, AnaSantos, ErnestinaTorres, TiagoAlmeida, IsabelFarinha, FátimaBarbosa, PauloMarinho, AntónioSelores, ManuelaCorreia, JoãoVasconcelos, CarlosCosta, Paulo P.da Silva, Berta Martins2016-02-12T15:29:30Z2015-10-292015-10-29T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/3282engJ Immunol Res. 2015;2015:948723. doi: 10.1155/2015/948723. Epub 2015 Oct 292314-886110.1155/2015/948723info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:39:51Zoai:repositorio.insa.pt:10400.18/3282Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:38:24.724201Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The Protective Role of HLA-DRB1(*)13 in Autoimmune Diseases |
title |
The Protective Role of HLA-DRB1(*)13 in Autoimmune Diseases |
spellingShingle |
The Protective Role of HLA-DRB1(*)13 in Autoimmune Diseases Bettencourt, Andreia Dermatology and Venerology Clinical Genetics Internal Medicine Rheumatology Microbiology immunology Autoimmune Diseases HLA Immunogenetics Clinical immunology Doenças Genéticas Determinantes da Saúde e da Doença |
title_short |
The Protective Role of HLA-DRB1(*)13 in Autoimmune Diseases |
title_full |
The Protective Role of HLA-DRB1(*)13 in Autoimmune Diseases |
title_fullStr |
The Protective Role of HLA-DRB1(*)13 in Autoimmune Diseases |
title_full_unstemmed |
The Protective Role of HLA-DRB1(*)13 in Autoimmune Diseases |
title_sort |
The Protective Role of HLA-DRB1(*)13 in Autoimmune Diseases |
author |
Bettencourt, Andreia |
author_facet |
Bettencourt, Andreia Carvalho, Cláudia Leal, Bárbara Brás, Sandra Lopes, Dina Martins da Silva, Ana Santos, Ernestina Torres, Tiago Almeida, Isabel Farinha, Fátima Barbosa, Paulo Marinho, António Selores, Manuela Correia, João Vasconcelos, Carlos Costa, Paulo P. da Silva, Berta Martins |
author_role |
author |
author2 |
Carvalho, Cláudia Leal, Bárbara Brás, Sandra Lopes, Dina Martins da Silva, Ana Santos, Ernestina Torres, Tiago Almeida, Isabel Farinha, Fátima Barbosa, Paulo Marinho, António Selores, Manuela Correia, João Vasconcelos, Carlos Costa, Paulo P. da Silva, Berta Martins |
author2_role |
author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Bettencourt, Andreia Carvalho, Cláudia Leal, Bárbara Brás, Sandra Lopes, Dina Martins da Silva, Ana Santos, Ernestina Torres, Tiago Almeida, Isabel Farinha, Fátima Barbosa, Paulo Marinho, António Selores, Manuela Correia, João Vasconcelos, Carlos Costa, Paulo P. da Silva, Berta Martins |
dc.subject.por.fl_str_mv |
Dermatology and Venerology Clinical Genetics Internal Medicine Rheumatology Microbiology immunology Autoimmune Diseases HLA Immunogenetics Clinical immunology Doenças Genéticas Determinantes da Saúde e da Doença |
topic |
Dermatology and Venerology Clinical Genetics Internal Medicine Rheumatology Microbiology immunology Autoimmune Diseases HLA Immunogenetics Clinical immunology Doenças Genéticas Determinantes da Saúde e da Doença |
description |
Autoimmune diseases (AIDs) are characterized by a multifactorial aetiology and a complex genetic background, with the MHC region playing a major role. We genotyped for HLA-DRB1 locus 1228 patients with AIDs-213 with Systemic Lupus Erythematosus (SLE), 166 with Psoriasis or Psoriatic Arthritis (Ps + PsA), 153 with Rheumatoid Arthritis (RA), 67 with Systemic Sclerosis (SSc), 536 with Multiple Sclerosis (MS), and 93 with Myasthenia Gravis (MG) and 282 unrelated controls. We confirmed previously established associations of HLA-DRB1(∗)15 (OR = 2.17) and HLA-DRB1(∗)03 (OR = 1.81) alleles with MS, HLA-DRB1(∗)03 with SLE (OR = 2.49), HLA-DRB1(∗)01 (OR = 1.79) and HLA-DRB1(∗)04 (OR = 2.81) with RA, HLA-DRB1(∗)07 with Ps + PsA (OR = 1.79), HLA-DRB1(∗)01 (OR = 2.28) and HLA-DRB1(∗)08 (OR = 3.01) with SSc, and HLA-DRB1(∗)03 with MG (OR = 2.98). We further observed a consistent negative association of HLA-DRB1(∗)13 allele with SLE, Ps + PsA, RA, and SSc (18.3%, 19.3%, 16.3%, and 11.9%, resp., versus 29.8% in controls). HLA-DRB1(∗)13 frequency in the AIDs group was 20.0% (OR = 0.58). Although different alleles were associated with particular AIDs, the same allele, HLA-DRB1(∗)13, was underrepresented in all of the six diseases analysed. This observation suggests that this allele may confer protection for AIDs, particularly for systemic and rheumatic disease. The protective effect of HLA-DRB1(∗)13 could be explained by a more proficient antigen presentation by these molecules, favouring efficient clonal deletion during thymic selection. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-10-29 2015-10-29T00:00:00Z 2016-02-12T15:29:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/3282 |
url |
http://hdl.handle.net/10400.18/3282 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
J Immunol Res. 2015;2015:948723. doi: 10.1155/2015/948723. Epub 2015 Oct 29 2314-8861 10.1155/2015/948723 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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