Immune-evasion strategies of mycobacteria and their implications for the protective immune response

Detalhes bibliográficos
Autor(a) principal: Fraga, Alexandra G.
Data de Publicação: 2018
Outros Autores: Barbosa, Ana Margarida Martins, Ferreira, Catarina Machado, Fevereiro, João, Pedrosa, Jorge, Torrado, Egídio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/58076
Resumo: Mycobacteria are intracellular pathogens that have macrophages as their main host cells. However, macrophages are also the primary line of defense against invading microorganisms. To survive in the intracellular compartment, virulent mycobacteria have developed several strategies to modulate the activation and the effector functions of macrophages. Despite this, antigen-specific T cells develop during infection. While T cell responses are critical for protection they can also contribute to the success of mycobacteria as human pathogens, as immunopathology associated with these responses facilitates transmission. Here, we provide a brief overview of different immune-evasion strategies of mycobacteria and their impact on the protective immune response. This understanding will further our knowledge in host-pathogen interactions and may provide critical insights for the development of novel host-specific therapies.
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spelling Immune-evasion strategies of mycobacteria and their implications for the protective immune responseAdaptive ImmunityAnimalsCytokinesDendritic CellsGene Expression RegulationHumansImmunity, InnateMacrophagesMycobacteriumMycobacterium tuberculosisNLR ProteinsPhagosomesSignal TransductionT-LymphocytesToll-Like ReceptorsImmune EvasionScience & TechnologyMycobacteria are intracellular pathogens that have macrophages as their main host cells. However, macrophages are also the primary line of defense against invading microorganisms. To survive in the intracellular compartment, virulent mycobacteria have developed several strategies to modulate the activation and the effector functions of macrophages. Despite this, antigen-specific T cells develop during infection. While T cell responses are critical for protection they can also contribute to the success of mycobacteria as human pathogens, as immunopathology associated with these responses facilitates transmission. Here, we provide a brief overview of different immune-evasion strategies of mycobacteria and their impact on the protective immune response. This understanding will further our knowledge in host-pathogen interactions and may provide critical insights for the development of novel host-specific therapies.Our work is funded by the project NORTE-01-0145-FEDER-000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER); Infect-ERA grant BU_SPONT_HEAL; and the Fundação para a Ciência e Tecnologia (FCT) through the FCT investigator grant IF/01390/2014 to E.T. and the postdoctoral grant SFRH/BPD/112903/2015 to A.G.F.info:eu-repo/semantics/publishedVersionCaister Academic PressUniversidade do MinhoFraga, Alexandra G.Barbosa, Ana Margarida MartinsFerreira, Catarina MachadoFevereiro, JoãoPedrosa, JorgeTorrado, Egídio20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/58076eng1467-30371467-304510.21775/cimb.025.16928875944info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:13:49Zoai:repositorium.sdum.uminho.pt:1822/58076Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:06:00.189316Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Immune-evasion strategies of mycobacteria and their implications for the protective immune response
title Immune-evasion strategies of mycobacteria and their implications for the protective immune response
spellingShingle Immune-evasion strategies of mycobacteria and their implications for the protective immune response
Fraga, Alexandra G.
Adaptive Immunity
Animals
Cytokines
Dendritic Cells
Gene Expression Regulation
Humans
Immunity, Innate
Macrophages
Mycobacterium
Mycobacterium tuberculosis
NLR Proteins
Phagosomes
Signal Transduction
T-Lymphocytes
Toll-Like Receptors
Immune Evasion
Science & Technology
title_short Immune-evasion strategies of mycobacteria and their implications for the protective immune response
title_full Immune-evasion strategies of mycobacteria and their implications for the protective immune response
title_fullStr Immune-evasion strategies of mycobacteria and their implications for the protective immune response
title_full_unstemmed Immune-evasion strategies of mycobacteria and their implications for the protective immune response
title_sort Immune-evasion strategies of mycobacteria and their implications for the protective immune response
author Fraga, Alexandra G.
author_facet Fraga, Alexandra G.
Barbosa, Ana Margarida Martins
Ferreira, Catarina Machado
Fevereiro, João
Pedrosa, Jorge
Torrado, Egídio
author_role author
author2 Barbosa, Ana Margarida Martins
Ferreira, Catarina Machado
Fevereiro, João
Pedrosa, Jorge
Torrado, Egídio
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Fraga, Alexandra G.
Barbosa, Ana Margarida Martins
Ferreira, Catarina Machado
Fevereiro, João
Pedrosa, Jorge
Torrado, Egídio
dc.subject.por.fl_str_mv Adaptive Immunity
Animals
Cytokines
Dendritic Cells
Gene Expression Regulation
Humans
Immunity, Innate
Macrophages
Mycobacterium
Mycobacterium tuberculosis
NLR Proteins
Phagosomes
Signal Transduction
T-Lymphocytes
Toll-Like Receptors
Immune Evasion
Science & Technology
topic Adaptive Immunity
Animals
Cytokines
Dendritic Cells
Gene Expression Regulation
Humans
Immunity, Innate
Macrophages
Mycobacterium
Mycobacterium tuberculosis
NLR Proteins
Phagosomes
Signal Transduction
T-Lymphocytes
Toll-Like Receptors
Immune Evasion
Science & Technology
description Mycobacteria are intracellular pathogens that have macrophages as their main host cells. However, macrophages are also the primary line of defense against invading microorganisms. To survive in the intracellular compartment, virulent mycobacteria have developed several strategies to modulate the activation and the effector functions of macrophages. Despite this, antigen-specific T cells develop during infection. While T cell responses are critical for protection they can also contribute to the success of mycobacteria as human pathogens, as immunopathology associated with these responses facilitates transmission. Here, we provide a brief overview of different immune-evasion strategies of mycobacteria and their impact on the protective immune response. This understanding will further our knowledge in host-pathogen interactions and may provide critical insights for the development of novel host-specific therapies.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/58076
url http://hdl.handle.net/1822/58076
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1467-3037
1467-3045
10.21775/cimb.025.169
28875944
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Caister Academic Press
publisher.none.fl_str_mv Caister Academic Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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