Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy

Detalhes bibliográficos
Autor(a) principal: Santos, Filipa
Data de Publicação: 2023
Outros Autores: Pires, David, Anes, Elsa, Duarte, Ana Rita C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/154569
Resumo: Funding Information: This project has received funding from the European Union’s Horizon 2020 (European Research Council) under grant agreement No ERC-2016-CoG 725034 and was supported by the Associate Laboratory for Green Chemistry-LAQV. We also thank the support of ADEIM-FFUL (Associação para o Ensino e a Investigação em Microbiologia). Publisher Copyright: © 2023 The Author(s)
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spelling Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapyAnti-tuberculosis drugsEutectic mixturesTherapeutic liquid mixturesTuberculosisPharmaceutical ScienceSDG 3 - Good Health and Well-beingFunding Information: This project has received funding from the European Union’s Horizon 2020 (European Research Council) under grant agreement No ERC-2016-CoG 725034 and was supported by the Associate Laboratory for Green Chemistry-LAQV. We also thank the support of ADEIM-FFUL (Associação para o Ensino e a Investigação em Microbiologia). Publisher Copyright: © 2023 The Author(s)Therapeutic liquid mixtures, as deep eutectic systems, are considered a sustainable strategy that can be useful for the modification and enhancement of the pharmacokinetics and pharmacodynamics of different active ingredients. In this study, we assessed the stability and antibacterial activity of therapeutic liquid formulations prepared with anti-tuberculosis drugs. Tuberculosis therapy presents various pitfalls related, for example, to the administration of prolonged regimens of multiple drugs, different severe adverse effects, low compliance of the patient to treatment and the development of drug resistance. During this study, it was possible to assess the physicochemical stability of the formulations for 6 months, by polarized optical microscopy, 1H NMR and FTIR-ATR. Furthermore, the mixtures present an antibacterial effect against a drug-susceptible Mycobacterium tuberculosis strain (H37Rv). This was particularly evident for the mixtures with ethambutol incorporated, making them interesting to pursue with further studies and evaluation of clinical applicability. Upon infection, it was also observed that a single and higher dose appears to be more effective than lower separate doses, which could allow the production of patient-friendly formulations.DQ - Departamento de QuímicaLAQV@REQUIMTERUNSantos, FilipaPires, DavidAnes, ElsaDuarte, Ana Rita C.2023-06-28T22:19:08Z2023-04-252023-04-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12application/pdfhttp://hdl.handle.net/10362/154569eng0378-5173PURE: 64822282https://doi.org/10.1016/j.ijpharm.2023.122862info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:37:01Zoai:run.unl.pt:10362/154569Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:40.634879Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy
title Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy
spellingShingle Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy
Santos, Filipa
Anti-tuberculosis drugs
Eutectic mixtures
Therapeutic liquid mixtures
Tuberculosis
Pharmaceutical Science
SDG 3 - Good Health and Well-being
title_short Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy
title_full Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy
title_fullStr Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy
title_full_unstemmed Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy
title_sort Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy
author Santos, Filipa
author_facet Santos, Filipa
Pires, David
Anes, Elsa
Duarte, Ana Rita C.
author_role author
author2 Pires, David
Anes, Elsa
Duarte, Ana Rita C.
author2_role author
author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
LAQV@REQUIMTE
RUN
dc.contributor.author.fl_str_mv Santos, Filipa
Pires, David
Anes, Elsa
Duarte, Ana Rita C.
dc.subject.por.fl_str_mv Anti-tuberculosis drugs
Eutectic mixtures
Therapeutic liquid mixtures
Tuberculosis
Pharmaceutical Science
SDG 3 - Good Health and Well-being
topic Anti-tuberculosis drugs
Eutectic mixtures
Therapeutic liquid mixtures
Tuberculosis
Pharmaceutical Science
SDG 3 - Good Health and Well-being
description Funding Information: This project has received funding from the European Union’s Horizon 2020 (European Research Council) under grant agreement No ERC-2016-CoG 725034 and was supported by the Associate Laboratory for Green Chemistry-LAQV. We also thank the support of ADEIM-FFUL (Associação para o Ensino e a Investigação em Microbiologia). Publisher Copyright: © 2023 The Author(s)
publishDate 2023
dc.date.none.fl_str_mv 2023-06-28T22:19:08Z
2023-04-25
2023-04-25T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/154569
url http://hdl.handle.net/10362/154569
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0378-5173
PURE: 64822282
https://doi.org/10.1016/j.ijpharm.2023.122862
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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