Cross-talk between inflammation, coagulation/fibrinolysis and vascular access in hemodialysis patients
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/2916 |
Resumo: | This work aimed to study the association between fibrinolytic/endothelial cell function and inflammatory markers in chronic kidney disease (CKD) patients undergoing hemodialysis (HD) and recombinant human erythropoietin (rhEPO) therapies, and its relationship with the type of vascular access (VA) used for the HD procedure. As fibrinolytic/endothelial cell function markers we evaluated plasminogen activator inhibitor type-1 (PAI-1), tissue plasminogen activator (tPA) and D-dimers, and as inflammatory markers; C-reactive protein (CRP), soluble interleukin (IL)-2 receptor (s-IL2R), IL-6 and serum albumin levels. The study was performed in 50 CKD patients undergoing regular HD, 11 with a central venous dialysis catheter (CVC) and 39 with an arteriovenous fistula (AVF), and in 25 healthy controls. Compared to controls, CKD patients presented with significantly higher levels of CRP, s-IL2R, IL-6 and D-dimers, and significantly lower levels of PAI-1. The tPA/PAI-1 ratio was significantly higher in CKD patients. We also found statistical significant correlations in CKD patients between D-dimers levels and inflammatory markers: CRP, albumin, s-IL2R and IL-6. When comparing the two groups of CKD patients, we found that those with a CVC presented statistically significant lower levels of hemoglobin concentration and albumin, and higher levels of CRP, IL-6, D-dimers and tPA. Our results showed an association between fibrinolytic/endothelial cell function and increased inflammatory markers in CKD patients. The increased levels of Ddimer, tPA and inflammatory markers in CKD patients using a CVC, led us to propose a relationship between the type of VA chosen for HD, and the risk of thrombogenesis. |
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Cross-talk between inflammation, coagulation/fibrinolysis and vascular access in hemodialysis patientsFibrinolytic activityChronic renal failureVascular accessD-dimersThis work aimed to study the association between fibrinolytic/endothelial cell function and inflammatory markers in chronic kidney disease (CKD) patients undergoing hemodialysis (HD) and recombinant human erythropoietin (rhEPO) therapies, and its relationship with the type of vascular access (VA) used for the HD procedure. As fibrinolytic/endothelial cell function markers we evaluated plasminogen activator inhibitor type-1 (PAI-1), tissue plasminogen activator (tPA) and D-dimers, and as inflammatory markers; C-reactive protein (CRP), soluble interleukin (IL)-2 receptor (s-IL2R), IL-6 and serum albumin levels. The study was performed in 50 CKD patients undergoing regular HD, 11 with a central venous dialysis catheter (CVC) and 39 with an arteriovenous fistula (AVF), and in 25 healthy controls. Compared to controls, CKD patients presented with significantly higher levels of CRP, s-IL2R, IL-6 and D-dimers, and significantly lower levels of PAI-1. The tPA/PAI-1 ratio was significantly higher in CKD patients. We also found statistical significant correlations in CKD patients between D-dimers levels and inflammatory markers: CRP, albumin, s-IL2R and IL-6. When comparing the two groups of CKD patients, we found that those with a CVC presented statistically significant lower levels of hemoglobin concentration and albumin, and higher levels of CRP, IL-6, D-dimers and tPA. Our results showed an association between fibrinolytic/endothelial cell function and increased inflammatory markers in CKD patients. The increased levels of Ddimer, tPA and inflammatory markers in CKD patients using a CVC, led us to propose a relationship between the type of VA chosen for HD, and the risk of thrombogenesis.Wichtig EditoreVeritati - Repositório Institucional da Universidade Católica PortuguesaCosta, ElísioRocha, SusanaRocha-Pereira, PetronilaCastro, E.Reis, FlávioTeixeira, FredericoMiranda, VascoFaria, Maria do SameiroLoureiro, AlfredoQuintanilha, AlexandreBelo, LuísSantos-Silva, Alice2010-10-14T12:24:35Z20082008-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/2916engCOSTA, Elísio ...[et al.] - Cross-talk between inflammation, coagulation/fibrinolysis and vascular access in hemodialysis patients. The Journal of Vascular Access. ISSN 1724-6032. Vol. 9, n.º 4 (2008), p. 248-25310.1177/112972980800900405info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-12T17:09:44Zoai:repositorio.ucp.pt:10400.14/2916Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:05:14.755308Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Cross-talk between inflammation, coagulation/fibrinolysis and vascular access in hemodialysis patients |
title |
Cross-talk between inflammation, coagulation/fibrinolysis and vascular access in hemodialysis patients |
spellingShingle |
Cross-talk between inflammation, coagulation/fibrinolysis and vascular access in hemodialysis patients Costa, Elísio Fibrinolytic activity Chronic renal failure Vascular access D-dimers |
title_short |
Cross-talk between inflammation, coagulation/fibrinolysis and vascular access in hemodialysis patients |
title_full |
Cross-talk between inflammation, coagulation/fibrinolysis and vascular access in hemodialysis patients |
title_fullStr |
Cross-talk between inflammation, coagulation/fibrinolysis and vascular access in hemodialysis patients |
title_full_unstemmed |
Cross-talk between inflammation, coagulation/fibrinolysis and vascular access in hemodialysis patients |
title_sort |
Cross-talk between inflammation, coagulation/fibrinolysis and vascular access in hemodialysis patients |
author |
Costa, Elísio |
author_facet |
Costa, Elísio Rocha, Susana Rocha-Pereira, Petronila Castro, E. Reis, Flávio Teixeira, Frederico Miranda, Vasco Faria, Maria do Sameiro Loureiro, Alfredo Quintanilha, Alexandre Belo, Luís Santos-Silva, Alice |
author_role |
author |
author2 |
Rocha, Susana Rocha-Pereira, Petronila Castro, E. Reis, Flávio Teixeira, Frederico Miranda, Vasco Faria, Maria do Sameiro Loureiro, Alfredo Quintanilha, Alexandre Belo, Luís Santos-Silva, Alice |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Costa, Elísio Rocha, Susana Rocha-Pereira, Petronila Castro, E. Reis, Flávio Teixeira, Frederico Miranda, Vasco Faria, Maria do Sameiro Loureiro, Alfredo Quintanilha, Alexandre Belo, Luís Santos-Silva, Alice |
dc.subject.por.fl_str_mv |
Fibrinolytic activity Chronic renal failure Vascular access D-dimers |
topic |
Fibrinolytic activity Chronic renal failure Vascular access D-dimers |
description |
This work aimed to study the association between fibrinolytic/endothelial cell function and inflammatory markers in chronic kidney disease (CKD) patients undergoing hemodialysis (HD) and recombinant human erythropoietin (rhEPO) therapies, and its relationship with the type of vascular access (VA) used for the HD procedure. As fibrinolytic/endothelial cell function markers we evaluated plasminogen activator inhibitor type-1 (PAI-1), tissue plasminogen activator (tPA) and D-dimers, and as inflammatory markers; C-reactive protein (CRP), soluble interleukin (IL)-2 receptor (s-IL2R), IL-6 and serum albumin levels. The study was performed in 50 CKD patients undergoing regular HD, 11 with a central venous dialysis catheter (CVC) and 39 with an arteriovenous fistula (AVF), and in 25 healthy controls. Compared to controls, CKD patients presented with significantly higher levels of CRP, s-IL2R, IL-6 and D-dimers, and significantly lower levels of PAI-1. The tPA/PAI-1 ratio was significantly higher in CKD patients. We also found statistical significant correlations in CKD patients between D-dimers levels and inflammatory markers: CRP, albumin, s-IL2R and IL-6. When comparing the two groups of CKD patients, we found that those with a CVC presented statistically significant lower levels of hemoglobin concentration and albumin, and higher levels of CRP, IL-6, D-dimers and tPA. Our results showed an association between fibrinolytic/endothelial cell function and increased inflammatory markers in CKD patients. The increased levels of Ddimer, tPA and inflammatory markers in CKD patients using a CVC, led us to propose a relationship between the type of VA chosen for HD, and the risk of thrombogenesis. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008 2008-01-01T00:00:00Z 2010-10-14T12:24:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/2916 |
url |
http://hdl.handle.net/10400.14/2916 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
COSTA, Elísio ...[et al.] - Cross-talk between inflammation, coagulation/fibrinolysis and vascular access in hemodialysis patients. The Journal of Vascular Access. ISSN 1724-6032. Vol. 9, n.º 4 (2008), p. 248-253 10.1177/112972980800900405 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wichtig Editore |
publisher.none.fl_str_mv |
Wichtig Editore |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799131715498672129 |