Phylogeography of hepatitis B virus: the role of Portugal in the early dissemination of HBV worldwide

Detalhes bibliográficos
Autor(a) principal: Marcelino, Rute
Data de Publicação: 2022
Outros Autores: Ezeonwumelu, Ifeanyi Jude, Janeiro, André, Mimoso, Paula, Matos, Sónia, Briz, Veronica, Pimentel, Victor, Pingarilho, Marta, Marinho, Rui, Maria Marcelino, José, Taveira, Nuno, Abecasis, Ana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/55661
Resumo: Copyright: © 2022 Marcelino et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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spelling Phylogeography of hepatitis B virus: the role of Portugal in the early dissemination of HBV worldwideCopyright: © 2022 Marcelino et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.In Portugal, the genetic diversity, origin of HBV and the Portuguese role in the dissemination of HBV worldwide were never investigated. In this work, we studied the epidemic history and transmission dynamics of HBV genotypes that are endemic in Portugal. HBV pol gene was sequenced from 130 patients followed in Lisbon. HBV genotype A was the most prevalent (n = 54, 41.5%), followed by D (n = 44, 33.8%), and E (n = 32, 24.6%). Spatio-temporal evolutionary dynamics was reconstructed in BEAST using a Bayesian Markov Chain Monte Carlo method, with a GTR nucleotide substitution model, an uncorrelated lognormal relaxed molecular clock model, a Bayesian skyline plot, and a continuous diffusion model. HBV subgenotype D4 was the first to be introduced in Portugal around 1857 (HPD 95% 1699-1931) followed by D3 and A2 a few decades later. HBV genotype E and subgenotype A1 were introduced in Portugal later, almost simultaneously. Our results indicate a very important role of Portugal in the exportation of subgenotypes D4 and A2 to Brazil and Cape Verde, respectively, in the beginning of the XX century. This work clarifies the epidemiological history of HBV in Portugal and provides new insights in the early and global epidemic history of this virus.This work was performed in the context of Rute Marcelino PhD study, whose student’s fellowship (SFRH/BD/99507/2014) was supported by the Portuguese Agency for Scientific Research, Fundação para a Ciência e Tecnologia (FCT), POCH program, Portugal 2020, and European Union/Social European Fund (FSE). This work was also supported by FCT through funds of AA's projects GHTM-UID/Multi/04413/2013 and GHTM-UID/04413/2020 and also NT's projects UIDB/04138/2020 and UIDP/04138/2020.FrontiersRepositório da Universidade de LisboaMarcelino, RuteEzeonwumelu, Ifeanyi JudeJaneiro, AndréMimoso, PaulaMatos, SóniaBriz, VeronicaPimentel, VictorPingarilho, MartaMarinho, RuiMaria Marcelino, JoséTaveira, NunoAbecasis, Ana2023-01-05T14:04:41Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/55661engPLoS One. 2022 Dec 22;17(12):e027661810.1371/journal.pone.02766181932-6203info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:02:32Zoai:repositorio.ul.pt:10451/55661Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:06:09.943245Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Phylogeography of hepatitis B virus: the role of Portugal in the early dissemination of HBV worldwide
title Phylogeography of hepatitis B virus: the role of Portugal in the early dissemination of HBV worldwide
spellingShingle Phylogeography of hepatitis B virus: the role of Portugal in the early dissemination of HBV worldwide
Marcelino, Rute
title_short Phylogeography of hepatitis B virus: the role of Portugal in the early dissemination of HBV worldwide
title_full Phylogeography of hepatitis B virus: the role of Portugal in the early dissemination of HBV worldwide
title_fullStr Phylogeography of hepatitis B virus: the role of Portugal in the early dissemination of HBV worldwide
title_full_unstemmed Phylogeography of hepatitis B virus: the role of Portugal in the early dissemination of HBV worldwide
title_sort Phylogeography of hepatitis B virus: the role of Portugal in the early dissemination of HBV worldwide
author Marcelino, Rute
author_facet Marcelino, Rute
Ezeonwumelu, Ifeanyi Jude
Janeiro, André
Mimoso, Paula
Matos, Sónia
Briz, Veronica
Pimentel, Victor
Pingarilho, Marta
Marinho, Rui
Maria Marcelino, José
Taveira, Nuno
Abecasis, Ana
author_role author
author2 Ezeonwumelu, Ifeanyi Jude
Janeiro, André
Mimoso, Paula
Matos, Sónia
Briz, Veronica
Pimentel, Victor
Pingarilho, Marta
Marinho, Rui
Maria Marcelino, José
Taveira, Nuno
Abecasis, Ana
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Marcelino, Rute
Ezeonwumelu, Ifeanyi Jude
Janeiro, André
Mimoso, Paula
Matos, Sónia
Briz, Veronica
Pimentel, Victor
Pingarilho, Marta
Marinho, Rui
Maria Marcelino, José
Taveira, Nuno
Abecasis, Ana
description Copyright: © 2022 Marcelino et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01T00:00:00Z
2023-01-05T14:04:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/55661
url http://hdl.handle.net/10451/55661
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PLoS One. 2022 Dec 22;17(12):e0276618
10.1371/journal.pone.0276618
1932-6203
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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