Influência da replicação do vírus da hepatite C em linfoma esplénico de células vilosas

Detalhes bibliográficos
Autor(a) principal: Raposo, João
Data de Publicação: 2010
Outros Autores: Nunes, Joana, Marinho, Rui Tato
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/21769
Resumo: The association between hepatitis C and B-cell non-Hodgkin lymphoma (NHL) has been suggested by several studies. We report the case of a 70 year-old patient with the diagnosis of chronic hepatitis C and splenic lymphoma with villous lymphocytes, who had undergone splenectomy and chemotherapy with fludarabine, with transient effectiveness. He was sent to our Hepatology Clinic for the treatment of hepatitis C, and Pegylated Interferon and Ribavirin were started. He had virological and hematological response (63% of villous lymphocytes in the peripheral blood at the beginning of therapy and 0% at the end). With the suspension of antiviral therapy, recurrence of HCV infection and reappearance of atypical lymphocytes (24%) were observed, and Pegylated Interferon was restarted, with good response. The relationship between viral and hematologic response (remission and relapse) supports the hypothesis that hepatitis C virus has an active role in the pathogenesis of splenic lymphoma with villous lymphocytes.
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spelling Influência da replicação do vírus da hepatite C em linfoma esplénico de células vilosasInfluence of hepatitis C virus replication on splenic lymphoma with villous lymphocytesNON-HODGKINS-LYMPHOMAB-CELLINFECTIONCRYOGLOBULINEMIAMETAANALYSISPREVALENCEREGRESSIONRISKSDG 3 - Good Health and Well-beingThe association between hepatitis C and B-cell non-Hodgkin lymphoma (NHL) has been suggested by several studies. We report the case of a 70 year-old patient with the diagnosis of chronic hepatitis C and splenic lymphoma with villous lymphocytes, who had undergone splenectomy and chemotherapy with fludarabine, with transient effectiveness. He was sent to our Hepatology Clinic for the treatment of hepatitis C, and Pegylated Interferon and Ribavirin were started. He had virological and hematological response (63% of villous lymphocytes in the peripheral blood at the beginning of therapy and 0% at the end). With the suspension of antiviral therapy, recurrence of HCV infection and reappearance of atypical lymphocytes (24%) were observed, and Pegylated Interferon was restarted, with good response. The relationship between viral and hematologic response (remission and relapse) supports the hypothesis that hepatitis C virus has an active role in the pathogenesis of splenic lymphoma with villous lymphocytes.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNRaposo, JoãoNunes, JoanaMarinho, Rui Tato2017-06-28T22:00:33Z2010-092010-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article4application/pdfhttp://hdl.handle.net/10362/21769por1646-0758PURE: 238609info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:08:44Zoai:run.unl.pt:10362/21769Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:26:57.176423Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Influência da replicação do vírus da hepatite C em linfoma esplénico de células vilosas
Influence of hepatitis C virus replication on splenic lymphoma with villous lymphocytes
title Influência da replicação do vírus da hepatite C em linfoma esplénico de células vilosas
spellingShingle Influência da replicação do vírus da hepatite C em linfoma esplénico de células vilosas
Raposo, João
NON-HODGKINS-LYMPHOMA
B-CELL
INFECTION
CRYOGLOBULINEMIA
METAANALYSIS
PREVALENCE
REGRESSION
RISK
SDG 3 - Good Health and Well-being
title_short Influência da replicação do vírus da hepatite C em linfoma esplénico de células vilosas
title_full Influência da replicação do vírus da hepatite C em linfoma esplénico de células vilosas
title_fullStr Influência da replicação do vírus da hepatite C em linfoma esplénico de células vilosas
title_full_unstemmed Influência da replicação do vírus da hepatite C em linfoma esplénico de células vilosas
title_sort Influência da replicação do vírus da hepatite C em linfoma esplénico de células vilosas
author Raposo, João
author_facet Raposo, João
Nunes, Joana
Marinho, Rui Tato
author_role author
author2 Nunes, Joana
Marinho, Rui Tato
author2_role author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Raposo, João
Nunes, Joana
Marinho, Rui Tato
dc.subject.por.fl_str_mv NON-HODGKINS-LYMPHOMA
B-CELL
INFECTION
CRYOGLOBULINEMIA
METAANALYSIS
PREVALENCE
REGRESSION
RISK
SDG 3 - Good Health and Well-being
topic NON-HODGKINS-LYMPHOMA
B-CELL
INFECTION
CRYOGLOBULINEMIA
METAANALYSIS
PREVALENCE
REGRESSION
RISK
SDG 3 - Good Health and Well-being
description The association between hepatitis C and B-cell non-Hodgkin lymphoma (NHL) has been suggested by several studies. We report the case of a 70 year-old patient with the diagnosis of chronic hepatitis C and splenic lymphoma with villous lymphocytes, who had undergone splenectomy and chemotherapy with fludarabine, with transient effectiveness. He was sent to our Hepatology Clinic for the treatment of hepatitis C, and Pegylated Interferon and Ribavirin were started. He had virological and hematological response (63% of villous lymphocytes in the peripheral blood at the beginning of therapy and 0% at the end). With the suspension of antiviral therapy, recurrence of HCV infection and reappearance of atypical lymphocytes (24%) were observed, and Pegylated Interferon was restarted, with good response. The relationship between viral and hematologic response (remission and relapse) supports the hypothesis that hepatitis C virus has an active role in the pathogenesis of splenic lymphoma with villous lymphocytes.
publishDate 2010
dc.date.none.fl_str_mv 2010-09
2010-09-01T00:00:00Z
2017-06-28T22:00:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/21769
url http://hdl.handle.net/10362/21769
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 1646-0758
PURE: 238609
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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