Elastic and ultradeformable liposomes for transdermal delivery of active pharmaceutical ingredients (APIs)
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/74017 |
Resumo: | Administration of active pharmaceutical ingredients (APIs) through the skin, by means of topical drug delivery systems, is an advanced therapeutic approach. As the skin is the largest organ of the human body, primarily acting as a natural protective barrier against permeation of xenobiotics, specific strategies to overcome this barrier are needed. Liposomes are nanometric-sized delivery systems composed of phospholipids, which are key components of cell membranes, making liposomes well tolerated and devoid of toxicity. As their lipid compositions are similar to those of the skin, liposomes are used as topical, dermal, and transdermal delivery systems. However, permeation of the first generation of liposomes through the skin posed some limitations; thus, a second generation of liposomes has emerged, overcoming permeability problems. Various mechanisms of permeation/penetration of elastic/ultra-deformable liposomes into the skin have been proposed; however, debate continues on their extent/mechanisms of permeation/penetration. In vivo bioavailability of an API administered in the form of ultra-deformable liposomes is similar to the bioavailability achieved when the same API is administered in the form of a solution by subcutaneous or epi-cutaneous injection, which demonstrates their applicability in transdermal drug delivery. |
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Elastic and ultradeformable liposomes for transdermal delivery of active pharmaceutical ingredients (APIs)Skin inflammatory diseasesPsoriasisPsoriasis vs. atopic dermatitisBiodegradable nanoparticlesMicroneedlesClinical trialspsoriasis vsatopic dermatitisScience & TechnologyAdministration of active pharmaceutical ingredients (APIs) through the skin, by means of topical drug delivery systems, is an advanced therapeutic approach. As the skin is the largest organ of the human body, primarily acting as a natural protective barrier against permeation of xenobiotics, specific strategies to overcome this barrier are needed. Liposomes are nanometric-sized delivery systems composed of phospholipids, which are key components of cell membranes, making liposomes well tolerated and devoid of toxicity. As their lipid compositions are similar to those of the skin, liposomes are used as topical, dermal, and transdermal delivery systems. However, permeation of the first generation of liposomes through the skin posed some limitations; thus, a second generation of liposomes has emerged, overcoming permeability problems. Various mechanisms of permeation/penetration of elastic/ultra-deformable liposomes into the skin have been proposed; however, debate continues on their extent/mechanisms of permeation/penetration. In vivo bioavailability of an API administered in the form of ultra-deformable liposomes is similar to the bioavailability achieved when the same API is administered in the form of a solution by subcutaneous or epi-cutaneous injection, which demonstrates their applicability in transdermal drug delivery.This research was funded by the Portuguese Science and Technology Foundation (FCT/ MCT) and European Funds (PRODER/COMPETE), under the project reference UIDB/04469/2020 (strategic fund), co-financed by FEDER, under the Partnership Agreement PT2020. The work is also supported by the National Science Centre within the MINIATURA 4 for a single research activity (grant No: 2020/04/X/ST5/00789) and by the START 2021 Program of the Foundation for Polish Science (FNP) granted to Aleksandra Zielinska.info:eu-repo/semantics/publishedVersionMDPIUniversidade do MinhoSouto, Eliana B.Macedo, Ana S.Dias-Ferreira, JoãoCano, AmandaZielinska, AleksandraMatos, Carla M.2021-092021-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/74017engSouto, Eliana; Macedo, Ana S.; Dias-Ferreira, João; Cano, Amanda; Zielinska, Aleksandra; Matos, Carla M., Elastic and ultradeformable liposomes for transdermal delivery of active pharmaceutical ingredients (APIs). International Journal of Molecular Sciences, 22(18), 9743, 20211424-67831422-006710.3390/ijms2218974334575907https://www.mdpi.com/1422-0067/22/18/9743info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:16:26Zoai:repositorium.sdum.uminho.pt:1822/74017Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:08:58.787440Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Elastic and ultradeformable liposomes for transdermal delivery of active pharmaceutical ingredients (APIs) |
title |
Elastic and ultradeformable liposomes for transdermal delivery of active pharmaceutical ingredients (APIs) |
spellingShingle |
Elastic and ultradeformable liposomes for transdermal delivery of active pharmaceutical ingredients (APIs) Souto, Eliana B. Skin inflammatory diseases Psoriasis Psoriasis vs. atopic dermatitis Biodegradable nanoparticles Microneedles Clinical trials psoriasis vs atopic dermatitis Science & Technology |
title_short |
Elastic and ultradeformable liposomes for transdermal delivery of active pharmaceutical ingredients (APIs) |
title_full |
Elastic and ultradeformable liposomes for transdermal delivery of active pharmaceutical ingredients (APIs) |
title_fullStr |
Elastic and ultradeformable liposomes for transdermal delivery of active pharmaceutical ingredients (APIs) |
title_full_unstemmed |
Elastic and ultradeformable liposomes for transdermal delivery of active pharmaceutical ingredients (APIs) |
title_sort |
Elastic and ultradeformable liposomes for transdermal delivery of active pharmaceutical ingredients (APIs) |
author |
Souto, Eliana B. |
author_facet |
Souto, Eliana B. Macedo, Ana S. Dias-Ferreira, João Cano, Amanda Zielinska, Aleksandra Matos, Carla M. |
author_role |
author |
author2 |
Macedo, Ana S. Dias-Ferreira, João Cano, Amanda Zielinska, Aleksandra Matos, Carla M. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Souto, Eliana B. Macedo, Ana S. Dias-Ferreira, João Cano, Amanda Zielinska, Aleksandra Matos, Carla M. |
dc.subject.por.fl_str_mv |
Skin inflammatory diseases Psoriasis Psoriasis vs. atopic dermatitis Biodegradable nanoparticles Microneedles Clinical trials psoriasis vs atopic dermatitis Science & Technology |
topic |
Skin inflammatory diseases Psoriasis Psoriasis vs. atopic dermatitis Biodegradable nanoparticles Microneedles Clinical trials psoriasis vs atopic dermatitis Science & Technology |
description |
Administration of active pharmaceutical ingredients (APIs) through the skin, by means of topical drug delivery systems, is an advanced therapeutic approach. As the skin is the largest organ of the human body, primarily acting as a natural protective barrier against permeation of xenobiotics, specific strategies to overcome this barrier are needed. Liposomes are nanometric-sized delivery systems composed of phospholipids, which are key components of cell membranes, making liposomes well tolerated and devoid of toxicity. As their lipid compositions are similar to those of the skin, liposomes are used as topical, dermal, and transdermal delivery systems. However, permeation of the first generation of liposomes through the skin posed some limitations; thus, a second generation of liposomes has emerged, overcoming permeability problems. Various mechanisms of permeation/penetration of elastic/ultra-deformable liposomes into the skin have been proposed; however, debate continues on their extent/mechanisms of permeation/penetration. In vivo bioavailability of an API administered in the form of ultra-deformable liposomes is similar to the bioavailability achieved when the same API is administered in the form of a solution by subcutaneous or epi-cutaneous injection, which demonstrates their applicability in transdermal drug delivery. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-09 2021-09-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/74017 |
url |
http://hdl.handle.net/1822/74017 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Souto, Eliana; Macedo, Ana S.; Dias-Ferreira, João; Cano, Amanda; Zielinska, Aleksandra; Matos, Carla M., Elastic and ultradeformable liposomes for transdermal delivery of active pharmaceutical ingredients (APIs). International Journal of Molecular Sciences, 22(18), 9743, 2021 1424-6783 1422-0067 10.3390/ijms22189743 34575907 https://www.mdpi.com/1422-0067/22/18/9743 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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