Synthesis, characterization, antioxidant and antiparasitic activities new naphthyl-thiazole derivatives

Detalhes bibliográficos
Autor(a) principal: Santos, Natali de França Nibbering
Data de Publicação: 2023
Outros Autores: Junior, Natanael da Silva Bezerra, de Oliveira, Jamerson Ferreira, Duarte, Denise Maria Figueiredo Araújo, Dos Santos Soares, José Cleberson, Clara Marques, Diego Santa, da Silva Santos, Aline Caroline, Nogueira, Fátima, Alves Pereira, Valéria Rêgo, Alves de Lima, Maria Carmo, da Cruz Filho, Iranildo José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/153926
Resumo: Copyright © 2023. Published by Elsevier Inc.
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spelling Synthesis, characterization, antioxidant and antiparasitic activities new naphthyl-thiazole derivativescitotoxity in animal cellsLeishmaniaPlasmodium falciparumThiazoles/pharmacologyThiosemicarbazones/pharmacologyTrypanosoma cruziRM Therapeutics. PharmacologyQR MicrobiologyRA0421 Public health. Hygiene. Preventive MedicineParasitologyPharmacology, Toxicology and Pharmaceutics(all)SDG 3 - Good Health and Well-beingSDG 9 - Industry, Innovation, and InfrastructureCopyright © 2023. Published by Elsevier Inc.In this work, 13 thiosemicarbazones (1a - m) and 16 thiazoles (2a - p) were obtained, which were properly characterized by spectroscopic and spectrometric techniques. The pharmacokinetic properties obtained in silico revealed that the derivatives are in accordance with the parameters established by lipinski and veber, showing that such compounds have good bioavailability or permeability when administered orally. In assays of antioxidant activity, thiosemicarbazones showed moderate to high antioxidant potential when compared to thiazoles. In addition, they were able to interact with albumin and DNA. Screening assays to assess the toxicity of compounds to mammalian cells revealed that thiosemicarbazones were less toxic when compared to thiazoles. In relation to in vitro antiparasitic activity, thiosemicarbazones and thiazoles showed cytotoxic potential against the parasites Leishmania amazonensis and Trypanosoma cruzi. Among the compounds, 1b, 1j and 2l stood out, showing inhibition potential for the amastigote forms of the two parasites. As for the in vitro antimalarial activity, thiosemicarbazones did not inhibit Plasmodium falciparum growth. In contrast, thiazoles promoted growth inhibition. This study shows in a preliminary way that the synthesized compounds have antiparasitic potential in vitro.Global Health and Tropical Medicine (GHTM)Instituto de Higiene e Medicina Tropical (IHMT)Vector borne diseases and pathogens (VBD)RUNSantos, Natali de França NibberingJunior, Natanael da Silva Bezerrade Oliveira, Jamerson FerreiraDuarte, Denise Maria Figueiredo AraújoDos Santos Soares, José ClebersonClara Marques, Diego Santada Silva Santos, Aline CarolineNogueira, FátimaAlves Pereira, Valéria RêgoAlves de Lima, Maria Carmoda Cruz Filho, Iranildo José2023-06-14T22:19:47Z2023-052023-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article14application/pdfhttp://hdl.handle.net/10362/153926eng0014-4894PURE: 61134152https://doi.org/10.1016/j.exppara.2023.108498info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:12:03Zoai:run.unl.pt:10362/153926Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:12:03Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Synthesis, characterization, antioxidant and antiparasitic activities new naphthyl-thiazole derivatives
title Synthesis, characterization, antioxidant and antiparasitic activities new naphthyl-thiazole derivatives
spellingShingle Synthesis, characterization, antioxidant and antiparasitic activities new naphthyl-thiazole derivatives
Santos, Natali de França Nibbering
citotoxity in animal cells
Leishmania
Plasmodium falciparum
Thiazoles/pharmacology
Thiosemicarbazones/pharmacology
Trypanosoma cruzi
RM Therapeutics. Pharmacology
QR Microbiology
RA0421 Public health. Hygiene. Preventive Medicine
Parasitology
Pharmacology, Toxicology and Pharmaceutics(all)
SDG 3 - Good Health and Well-being
SDG 9 - Industry, Innovation, and Infrastructure
title_short Synthesis, characterization, antioxidant and antiparasitic activities new naphthyl-thiazole derivatives
title_full Synthesis, characterization, antioxidant and antiparasitic activities new naphthyl-thiazole derivatives
title_fullStr Synthesis, characterization, antioxidant and antiparasitic activities new naphthyl-thiazole derivatives
title_full_unstemmed Synthesis, characterization, antioxidant and antiparasitic activities new naphthyl-thiazole derivatives
title_sort Synthesis, characterization, antioxidant and antiparasitic activities new naphthyl-thiazole derivatives
author Santos, Natali de França Nibbering
author_facet Santos, Natali de França Nibbering
Junior, Natanael da Silva Bezerra
de Oliveira, Jamerson Ferreira
Duarte, Denise Maria Figueiredo Araújo
Dos Santos Soares, José Cleberson
Clara Marques, Diego Santa
da Silva Santos, Aline Caroline
Nogueira, Fátima
Alves Pereira, Valéria Rêgo
Alves de Lima, Maria Carmo
da Cruz Filho, Iranildo José
author_role author
author2 Junior, Natanael da Silva Bezerra
de Oliveira, Jamerson Ferreira
Duarte, Denise Maria Figueiredo Araújo
Dos Santos Soares, José Cleberson
Clara Marques, Diego Santa
da Silva Santos, Aline Caroline
Nogueira, Fátima
Alves Pereira, Valéria Rêgo
Alves de Lima, Maria Carmo
da Cruz Filho, Iranildo José
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Global Health and Tropical Medicine (GHTM)
Instituto de Higiene e Medicina Tropical (IHMT)
Vector borne diseases and pathogens (VBD)
RUN
dc.contributor.author.fl_str_mv Santos, Natali de França Nibbering
Junior, Natanael da Silva Bezerra
de Oliveira, Jamerson Ferreira
Duarte, Denise Maria Figueiredo Araújo
Dos Santos Soares, José Cleberson
Clara Marques, Diego Santa
da Silva Santos, Aline Caroline
Nogueira, Fátima
Alves Pereira, Valéria Rêgo
Alves de Lima, Maria Carmo
da Cruz Filho, Iranildo José
dc.subject.por.fl_str_mv citotoxity in animal cells
Leishmania
Plasmodium falciparum
Thiazoles/pharmacology
Thiosemicarbazones/pharmacology
Trypanosoma cruzi
RM Therapeutics. Pharmacology
QR Microbiology
RA0421 Public health. Hygiene. Preventive Medicine
Parasitology
Pharmacology, Toxicology and Pharmaceutics(all)
SDG 3 - Good Health and Well-being
SDG 9 - Industry, Innovation, and Infrastructure
topic citotoxity in animal cells
Leishmania
Plasmodium falciparum
Thiazoles/pharmacology
Thiosemicarbazones/pharmacology
Trypanosoma cruzi
RM Therapeutics. Pharmacology
QR Microbiology
RA0421 Public health. Hygiene. Preventive Medicine
Parasitology
Pharmacology, Toxicology and Pharmaceutics(all)
SDG 3 - Good Health and Well-being
SDG 9 - Industry, Innovation, and Infrastructure
description Copyright © 2023. Published by Elsevier Inc.
publishDate 2023
dc.date.none.fl_str_mv 2023-06-14T22:19:47Z
2023-05
2023-05-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/153926
url http://hdl.handle.net/10362/153926
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0014-4894
PURE: 61134152
https://doi.org/10.1016/j.exppara.2023.108498
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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