Alendronic acid as ionic liquid: New perspective on osteosarcoma

Detalhes bibliográficos
Autor(a) principal: Teixeira, Sónia
Data de Publicação: 2020
Outros Autores: Santos, Miguel M., Fernandes, Maria H., Costa-Rodrigues, João, Branco, Luís C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/98894
Resumo: This work was supported by the Associate Laboratory for Green Chemistry LAQV which is financed by national funds from FCT/MCTES (UIDB/50006/2020). The authors also thank Fundacao para a Ciencia e Tecnologia for the projects PTDC/QUI-QOR/32406/2017, PEst-C/LA0006/2013 and RECI/BBBBQB/0230/2012), as well as one contract under Investigador FCT (L. C. Branco).
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spelling Alendronic acid as ionic liquid: New perspective on osteosarcomaActive pharmaceutical ingredientsAlendronic acidAnticancer drugsAPI-OSILsIonic liquidsPharmaceutical ScienceSDG 3 - Good Health and Well-beingThis work was supported by the Associate Laboratory for Green Chemistry LAQV which is financed by national funds from FCT/MCTES (UIDB/50006/2020). The authors also thank Fundacao para a Ciencia e Tecnologia for the projects PTDC/QUI-QOR/32406/2017, PEst-C/LA0006/2013 and RECI/BBBBQB/0230/2012), as well as one contract under Investigador FCT (L. C. Branco).Herein the quantitative synthesis of eight new mono-and dianionic Organic Salts and Ionic Liquids (OSILs) from alendronic acid (ALN) is reported by following two distinct sustainable and straightforward methodologies, according to the type of cation. The prepared ALN-OSILs were characterized by spectroscopic techniques and their solubility in water and biological fluids was determined. An evaluation of the toxicity towards human healthy cells and also human breast, lung and bone (osteosarcoma) cell lines was performed. Globally, it was observed that the monoanionic OSILs showed lower toxicity than the corresponding dianionic structures to all cell types. The highest cytotoxic effect was observed in OSILs containing a [C2OHMIM] cation, in particular [C2OHMIM][ALN]. The latter showed an improvement in IC50 values of ca. three orders of magnitude for the lung and bone cancer cell lines as well as fibroblasts in comparison with ALN. The development of OSILs with high cytotoxicity effect towards the tested cancer cell types, and containing an anti-resorbing molecule such as ALN may represent a promising strategy for the development of new pharmacological tools to be used in those pathological conditions.LAQV@REQUIMTEDQ - Departamento de QuímicaRUNTeixeira, SóniaSantos, Miguel M.Fernandes, Maria H.Costa-Rodrigues, JoãoBranco, Luís C.2020-06-05T00:53:00Z2020-032020-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/98894eng1999-4923PURE: 18447973https://doi.org/10.3390/pharmaceutics12030293info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T17:45:52Zoai:run.unl.pt:10362/98894Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T17:45:52Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Alendronic acid as ionic liquid: New perspective on osteosarcoma
title Alendronic acid as ionic liquid: New perspective on osteosarcoma
spellingShingle Alendronic acid as ionic liquid: New perspective on osteosarcoma
Teixeira, Sónia
Active pharmaceutical ingredients
Alendronic acid
Anticancer drugs
API-OSILs
Ionic liquids
Pharmaceutical Science
SDG 3 - Good Health and Well-being
title_short Alendronic acid as ionic liquid: New perspective on osteosarcoma
title_full Alendronic acid as ionic liquid: New perspective on osteosarcoma
title_fullStr Alendronic acid as ionic liquid: New perspective on osteosarcoma
title_full_unstemmed Alendronic acid as ionic liquid: New perspective on osteosarcoma
title_sort Alendronic acid as ionic liquid: New perspective on osteosarcoma
author Teixeira, Sónia
author_facet Teixeira, Sónia
Santos, Miguel M.
Fernandes, Maria H.
Costa-Rodrigues, João
Branco, Luís C.
author_role author
author2 Santos, Miguel M.
Fernandes, Maria H.
Costa-Rodrigues, João
Branco, Luís C.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv LAQV@REQUIMTE
DQ - Departamento de Química
RUN
dc.contributor.author.fl_str_mv Teixeira, Sónia
Santos, Miguel M.
Fernandes, Maria H.
Costa-Rodrigues, João
Branco, Luís C.
dc.subject.por.fl_str_mv Active pharmaceutical ingredients
Alendronic acid
Anticancer drugs
API-OSILs
Ionic liquids
Pharmaceutical Science
SDG 3 - Good Health and Well-being
topic Active pharmaceutical ingredients
Alendronic acid
Anticancer drugs
API-OSILs
Ionic liquids
Pharmaceutical Science
SDG 3 - Good Health and Well-being
description This work was supported by the Associate Laboratory for Green Chemistry LAQV which is financed by national funds from FCT/MCTES (UIDB/50006/2020). The authors also thank Fundacao para a Ciencia e Tecnologia for the projects PTDC/QUI-QOR/32406/2017, PEst-C/LA0006/2013 and RECI/BBBBQB/0230/2012), as well as one contract under Investigador FCT (L. C. Branco).
publishDate 2020
dc.date.none.fl_str_mv 2020-06-05T00:53:00Z
2020-03
2020-03-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/98894
url http://hdl.handle.net/10362/98894
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1999-4923
PURE: 18447973
https://doi.org/10.3390/pharmaceutics12030293
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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