Human mesenchymal stem cells response to multi-doped silicon-strontium calcium phosphate coatings

Detalhes bibliográficos
Autor(a) principal: Rodríguez-Valencia, Cosme
Data de Publicação: 2014
Outros Autores: Pereiro, Iago, Pirraco, Rogério, Lopéz-Álvarez, M., Serra, J., González, P., Marques, A. P., Reis, R. L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/27056
Resumo: The search for apatitic calcium phosphate coatings to improve implants osteointegration is, nowadays, preferentially focused in the obtaining of compositions closer to that of the inorganic phase of bone. Silicon and strontium are both present in trace concentrations in natural bone and have been demonstrated, by separate, to significantly improve osteoblastic response on calcium phosphate bioceramics. This work aims the controlled and simultaneous multidoping of carbonated calcium phosphate coatings with both elements, Si and Sr, by pulsed laser deposition technique and the biological response of human mesenchymal stem cells to them. A complete physicochemical characterization has been also performed to analyze the coatings and significant positive effect was obtained at the osteogenic differentiation of cells, confirming the enormous potential of this multi-doping coating approach.
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spelling Human mesenchymal stem cells response to multi-doped silicon-strontium calcium phosphate coatingsCalcium phosphateHuman bone marrow-derived mesenchymal stem cells differentiationMulti-doped coatingsPulsed laser depositionSiliconStrontiumScience & TechnologyThe search for apatitic calcium phosphate coatings to improve implants osteointegration is, nowadays, preferentially focused in the obtaining of compositions closer to that of the inorganic phase of bone. Silicon and strontium are both present in trace concentrations in natural bone and have been demonstrated, by separate, to significantly improve osteoblastic response on calcium phosphate bioceramics. This work aims the controlled and simultaneous multidoping of carbonated calcium phosphate coatings with both elements, Si and Sr, by pulsed laser deposition technique and the biological response of human mesenchymal stem cells to them. A complete physicochemical characterization has been also performed to analyze the coatings and significant positive effect was obtained at the osteogenic differentiation of cells, confirming the enormous potential of this multi-doping coating approach.Technical staff of CACTI (University of Vigo) is gratefully acknowledged. This work was partially supported by the UE-POCTEP 0330IBEROMARE1P project, UE-INTERREG 2011-1/164MARMED and Ministerio de Ciencia e Innovacion (Project MAT2010-18281). M Lopez-Alvarez thanks funding support from FP7/REGPOT-2012-2013.1 (no 316265, BIOCAPS).SAGEUniversidade do MinhoRodríguez-Valencia, CosmePereiro, IagoPirraco, RogérioLopéz-Álvarez, M.Serra, J.González, P.Marques, A. P.Reis, R. L.20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/27056eng0885-328210.1177/088532821351005624163332http://jba.sagepub.com/content/early/2013/10/25/0885328213510056.abstractinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:24:18Zoai:repositorium.sdum.uminho.pt:1822/27056Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:18:17.341050Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Human mesenchymal stem cells response to multi-doped silicon-strontium calcium phosphate coatings
title Human mesenchymal stem cells response to multi-doped silicon-strontium calcium phosphate coatings
spellingShingle Human mesenchymal stem cells response to multi-doped silicon-strontium calcium phosphate coatings
Rodríguez-Valencia, Cosme
Calcium phosphate
Human bone marrow-derived mesenchymal stem cells differentiation
Multi-doped coatings
Pulsed laser deposition
Silicon
Strontium
Science & Technology
title_short Human mesenchymal stem cells response to multi-doped silicon-strontium calcium phosphate coatings
title_full Human mesenchymal stem cells response to multi-doped silicon-strontium calcium phosphate coatings
title_fullStr Human mesenchymal stem cells response to multi-doped silicon-strontium calcium phosphate coatings
title_full_unstemmed Human mesenchymal stem cells response to multi-doped silicon-strontium calcium phosphate coatings
title_sort Human mesenchymal stem cells response to multi-doped silicon-strontium calcium phosphate coatings
author Rodríguez-Valencia, Cosme
author_facet Rodríguez-Valencia, Cosme
Pereiro, Iago
Pirraco, Rogério
Lopéz-Álvarez, M.
Serra, J.
González, P.
Marques, A. P.
Reis, R. L.
author_role author
author2 Pereiro, Iago
Pirraco, Rogério
Lopéz-Álvarez, M.
Serra, J.
González, P.
Marques, A. P.
Reis, R. L.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Rodríguez-Valencia, Cosme
Pereiro, Iago
Pirraco, Rogério
Lopéz-Álvarez, M.
Serra, J.
González, P.
Marques, A. P.
Reis, R. L.
dc.subject.por.fl_str_mv Calcium phosphate
Human bone marrow-derived mesenchymal stem cells differentiation
Multi-doped coatings
Pulsed laser deposition
Silicon
Strontium
Science & Technology
topic Calcium phosphate
Human bone marrow-derived mesenchymal stem cells differentiation
Multi-doped coatings
Pulsed laser deposition
Silicon
Strontium
Science & Technology
description The search for apatitic calcium phosphate coatings to improve implants osteointegration is, nowadays, preferentially focused in the obtaining of compositions closer to that of the inorganic phase of bone. Silicon and strontium are both present in trace concentrations in natural bone and have been demonstrated, by separate, to significantly improve osteoblastic response on calcium phosphate bioceramics. This work aims the controlled and simultaneous multidoping of carbonated calcium phosphate coatings with both elements, Si and Sr, by pulsed laser deposition technique and the biological response of human mesenchymal stem cells to them. A complete physicochemical characterization has been also performed to analyze the coatings and significant positive effect was obtained at the osteogenic differentiation of cells, confirming the enormous potential of this multi-doping coating approach.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/27056
url http://hdl.handle.net/1822/27056
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0885-3282
10.1177/0885328213510056
24163332
http://jba.sagepub.com/content/early/2013/10/25/0885328213510056.abstract
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SAGE
publisher.none.fl_str_mv SAGE
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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