Mantle cell lymphoma

• Autor(a) principal: Oliveira, Anabela
• Data de Publicação: 1999
• Outros Autores: Dutschaman , Luís
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://revista.spmi.pt/index.php/rpmi/article/view/2031
• topic: linfoma de células do manto; estudos imunofenotípicos; terapêutica; mantle cell lymphoma; immunophenotipic studies; therapy

ln the last years, newly lymphoid neoplasms werw recognized with clinical, morphologic and immunophenotypic characteristics distinct from the common  forms described in the Working Formulation. One of the newly variant oflymphoma recently recognized were the mantle cell lymphoma in 1992. Case report: the authors reporta case of 73-year­ old man admitted in our deparrtment with symptomatic anemia, poor performance status, generalized lymphadenopathy, splenomegaly and lymphocitosis in the blood peripherial. He presented a elevated lactate dehydrogenase and b2 microglobulin levels. After evaluation of disease, that included bone marrow biopsy, immunophenotypic stdies of blood marrow, lymph node biopsy, chest-abdomen-pelvic computed tomographic scan, we made the diagnosis of diffuse mantle cell lymphoma, stage IV of Ann Arbor staging classification. made a gastrointestinal endoscopy that revealed multiple nodules in stmach and duodenal bulb which histologic findings shows a diffuse envolvement by lymphomatous B cells. The patient was treated until now, with four cycles of cyclophosphamide, vincristine, mitoxantrone and prednisone with partial remission after reavaluation. We review the literature about this subject.