PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/1822/59781 |
Resumo: | Chronic diseases such as chagasic megaesophagus (secondary to Chagas' disease) have been suggested as etiological factors for esophageal squamous cell carcinoma; however, the molecular mechanisms involved are poorly understood. |
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PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcomeEsophageal cancerTrypanosoma cruzitionAchalasiaEsophageal squamous cell carcinomaChagasic megaesophagusPIK3CAMutationTrypanosoma cruziCiências Médicas::Medicina ClínicaScience & TechnologyChronic diseases such as chagasic megaesophagus (secondary to Chagas' disease) have been suggested as etiological factors for esophageal squamous cell carcinoma; however, the molecular mechanisms involved are poorly understood.Background Chronic diseases such as chagasic megaesophagus (secondary to Chagas’ disease) have been suggested as etiological factors for esophageal squamous cell carcinoma; however, the molecular mechanisms involved are poorly understood. Objective We analyzed hotspot PIK3CA gene mutations in a series of esophageal squamous cell carcinomas associated or not with chagasic megaesophagus, as well as, in chagasic megaesophagus biopsies. We also checked for correlations between the presence of PIK3CA mutations with patients’ clinical and pathological features. Methods The study included three different groups of patients: i) 23 patients with chagasic megaesophagus associated with esophageal squamous cell carcinoma (CM/ESCC); ii) 38 patients with esophageal squamous cell carcinoma not associated with chagasic megaesophagus (ESCC); and iii) 28 patients with chagasic megaesophagus without esophageal squamous cell carcinoma (CM). PIK3CA hotspot mutations in exons 9 and 20 were evaluated by PCR followed by direct sequencing technique. Results PIK3CA mutations were identified in 21.7% (5 out of 23) of CM/ESCC cases, in 10.5% (4 out of 38) of ESCC and in only 3.6% (1 case out of 28) of CM cases. In the CM/ESCC group, PIK3CA mutations were significantly associated with lower survival (mean 5 months), when compared to wild-type patients (mean 2.0 years). No other significant associations were observed between PIK3CA mutations and patients’ clinical features or TP53 mutation profile. Conclusion This is the first report on the presence of PIK3CA mutations in esophageal cancer associated with chagasic megaesophagus. The detection of PIK3CA mutations in benign chagasic megaesophagus lesions suggests their putative role in esophageal squamous cell carcinoma development and opens new opportunities for targeted-therapies for these diseases.CAPES and FAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo [Grant number 2015/20077–3 to FFM] and Barretos Cancer Hospital internal research funds (PAIP)info:eu-repo/semantics/publishedVersionSpringer NatureUniversidade do MinhoMunari, Fernanda FrancoCruvinel-Carloni, AdrianaLacerda, Croider Francode Oliveira, Antônio Talvane TorresScapulatempo-Neto, Cristovamda Silva, Sandra Regina MoriniCrema, EduardoAdad, Sheila JorgeRodrigues, Maria Aparecida MarchesanHenry, Maria Aparecida Coelho ArrudaGuimarães, Denise PeixotoLongatto, AdhemarReis, R. M.20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/59781engMunari, F. F., Cruvinel-Carloni, A., Lacerda, C. F., de Oliveira, A. T. T., et. al.(2018). PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome. Infectious agents and cancer, 13(1), 431750-93781750-937810.1186/s13027-018-0216-3https://infectagentscancer.biomedcentral.com/articles/10.1186/s13027-018-0216-3info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:38:25Zoai:repositorium.sdum.uminho.pt:1822/59781Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:34:52.130615Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome |
| title |
PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome |
| spellingShingle |
PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome Munari, Fernanda Franco Esophageal cancer Trypanosoma cruzition Achalasia Esophageal squamous cell carcinoma Chagasic megaesophagus PIK3CA Mutation Trypanosoma cruzi Ciências Médicas::Medicina Clínica Science & Technology |
| title_short |
PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome |
| title_full |
PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome |
| title_fullStr |
PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome |
| title_full_unstemmed |
PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome |
| title_sort |
PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome |
| author |
Munari, Fernanda Franco |
| author_facet |
Munari, Fernanda Franco Cruvinel-Carloni, Adriana Lacerda, Croider Franco de Oliveira, Antônio Talvane Torres Scapulatempo-Neto, Cristovam da Silva, Sandra Regina Morini Crema, Eduardo Adad, Sheila Jorge Rodrigues, Maria Aparecida Marchesan Henry, Maria Aparecida Coelho Arruda Guimarães, Denise Peixoto Longatto, Adhemar Reis, R. M. |
| author_role |
author |
| author2 |
Cruvinel-Carloni, Adriana Lacerda, Croider Franco de Oliveira, Antônio Talvane Torres Scapulatempo-Neto, Cristovam da Silva, Sandra Regina Morini Crema, Eduardo Adad, Sheila Jorge Rodrigues, Maria Aparecida Marchesan Henry, Maria Aparecida Coelho Arruda Guimarães, Denise Peixoto Longatto, Adhemar Reis, R. M. |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade do Minho |
| dc.contributor.author.fl_str_mv |
Munari, Fernanda Franco Cruvinel-Carloni, Adriana Lacerda, Croider Franco de Oliveira, Antônio Talvane Torres Scapulatempo-Neto, Cristovam da Silva, Sandra Regina Morini Crema, Eduardo Adad, Sheila Jorge Rodrigues, Maria Aparecida Marchesan Henry, Maria Aparecida Coelho Arruda Guimarães, Denise Peixoto Longatto, Adhemar Reis, R. M. |
| dc.subject.por.fl_str_mv |
Esophageal cancer Trypanosoma cruzition Achalasia Esophageal squamous cell carcinoma Chagasic megaesophagus PIK3CA Mutation Trypanosoma cruzi Ciências Médicas::Medicina Clínica Science & Technology |
| topic |
Esophageal cancer Trypanosoma cruzition Achalasia Esophageal squamous cell carcinoma Chagasic megaesophagus PIK3CA Mutation Trypanosoma cruzi Ciências Médicas::Medicina Clínica Science & Technology |
| description |
Chronic diseases such as chagasic megaesophagus (secondary to Chagas' disease) have been suggested as etiological factors for esophageal squamous cell carcinoma; however, the molecular mechanisms involved are poorly understood. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018 2018-01-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/59781 |
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http://hdl.handle.net/1822/59781 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Munari, F. F., Cruvinel-Carloni, A., Lacerda, C. F., de Oliveira, A. T. T., et. al.(2018). PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome. Infectious agents and cancer, 13(1), 43 1750-9378 1750-9378 10.1186/s13027-018-0216-3 https://infectagentscancer.biomedcentral.com/articles/10.1186/s13027-018-0216-3 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Springer Nature |
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Springer Nature |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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