Hematological evaluation in males with obstructive Sleep apnea before and after positive airway pressure
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/4920 |
Resumo: | Obstructive sleep apnea syndrome (OSAS) is a systemic inflammatory disease associated with cardiovascular consequences. Red blood cell distribution width (RDW), mean platelet volume (MPV), and platelet distribution width (PDW) are recognized biomarkers of cardiovascular morbidity/mortality. Limited data is available on the association between these parameters and OSAS severity and the relationship with positive airway pressure therapy (PAP). In this prospective study of male OSAS patients we analyzed hematological data in order to evaluate their value in predicting OSAS severity, the relationship with sleep parameters, and their behavior under PAP. Seventy-three patients were included (mean age 46.5 years), of which 36 were mild (49.3%), 10 moderate (13.7%), and 27 severe (37%). The mean RDW increased significantly with OSAS severity and showed a positive correlation with respiratory disturbance index and hypoxemic burdens. Additionally, a group of 48 patients (mean age 47.2 years) were submitted to PAP. After six months, red blood cell count, hemoglobin, hematocrit, and platelet count showed a significant decrease (p < 0.0001; p < 0.0001; p = 0.001; p < 0.0001; respectively). Concerning OSAS severity, these parameters also significantly decreased in mild patients (p = 0.003; p = 0.043; p = 0.020; p = 0.014; respectively) but only hemoglobin, hematocrit, and platelet count decreased in severe cases (p < 0.0001; p = 0.008; p = 0.018; respectively). This study demonstrated an association between RDW values and OSAS severity. Moreover, red cell and platelet parameters changed significantly after PAP, supporting its cardiovascular protective effect. RDW may become a simple/inexpensive blood biomarker, making it useful in prioritizing OSAS patients waiting for polysomnography, and red cell and platelet parameters could be useful in PAP follow up. |
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Hematological evaluation in males with obstructive Sleep apnea before and after positive airway pressureSleep ApneaObstructive sleep apnea syndrome (OSAS)Biomarkers of CardiovascularPlatelet parametersRed cell parametersDeterminantes da Saude e da DoençaApneia do SonoObstructive sleep apnea syndrome (OSAS) is a systemic inflammatory disease associated with cardiovascular consequences. Red blood cell distribution width (RDW), mean platelet volume (MPV), and platelet distribution width (PDW) are recognized biomarkers of cardiovascular morbidity/mortality. Limited data is available on the association between these parameters and OSAS severity and the relationship with positive airway pressure therapy (PAP). In this prospective study of male OSAS patients we analyzed hematological data in order to evaluate their value in predicting OSAS severity, the relationship with sleep parameters, and their behavior under PAP. Seventy-three patients were included (mean age 46.5 years), of which 36 were mild (49.3%), 10 moderate (13.7%), and 27 severe (37%). The mean RDW increased significantly with OSAS severity and showed a positive correlation with respiratory disturbance index and hypoxemic burdens. Additionally, a group of 48 patients (mean age 47.2 years) were submitted to PAP. After six months, red blood cell count, hemoglobin, hematocrit, and platelet count showed a significant decrease (p < 0.0001; p < 0.0001; p = 0.001; p < 0.0001; respectively). Concerning OSAS severity, these parameters also significantly decreased in mild patients (p = 0.003; p = 0.043; p = 0.020; p = 0.014; respectively) but only hemoglobin, hematocrit, and platelet count decreased in severe cases (p < 0.0001; p = 0.008; p = 0.018; respectively). This study demonstrated an association between RDW values and OSAS severity. Moreover, red cell and platelet parameters changed significantly after PAP, supporting its cardiovascular protective effect. RDW may become a simple/inexpensive blood biomarker, making it useful in prioritizing OSAS patients waiting for polysomnography, and red cell and platelet parameters could be useful in PAP follow up.Elsevier/Sociedade Portuguesa de PneumologiaRepositório Científico do Instituto Nacional de SaúdeFeliciano, AmeliaLinhas, R.Marçõa, R.Cysneiros, A.Martinho, C.Reis, R.P.Penque, DeborahPinto, P.Bárbara, Cristina2018-02-02T12:55:45Z2017-01-312017-01-31T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/4920engRev Port Pneumol. 2017;23(2):71-780873-215910.1016/j.rppnen.2016.12.001info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:30Zoai:repositorio.insa.pt:10400.18/4920Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:39:31.199084Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Hematological evaluation in males with obstructive Sleep apnea before and after positive airway pressure |
title |
Hematological evaluation in males with obstructive Sleep apnea before and after positive airway pressure |
spellingShingle |
Hematological evaluation in males with obstructive Sleep apnea before and after positive airway pressure Feliciano, Amelia Sleep Apnea Obstructive sleep apnea syndrome (OSAS) Biomarkers of Cardiovascular Platelet parameters Red cell parameters Determinantes da Saude e da Doença Apneia do Sono |
title_short |
Hematological evaluation in males with obstructive Sleep apnea before and after positive airway pressure |
title_full |
Hematological evaluation in males with obstructive Sleep apnea before and after positive airway pressure |
title_fullStr |
Hematological evaluation in males with obstructive Sleep apnea before and after positive airway pressure |
title_full_unstemmed |
Hematological evaluation in males with obstructive Sleep apnea before and after positive airway pressure |
title_sort |
Hematological evaluation in males with obstructive Sleep apnea before and after positive airway pressure |
author |
Feliciano, Amelia |
author_facet |
Feliciano, Amelia Linhas, R. Marçõa, R. Cysneiros, A. Martinho, C. Reis, R.P. Penque, Deborah Pinto, P. Bárbara, Cristina |
author_role |
author |
author2 |
Linhas, R. Marçõa, R. Cysneiros, A. Martinho, C. Reis, R.P. Penque, Deborah Pinto, P. Bárbara, Cristina |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Feliciano, Amelia Linhas, R. Marçõa, R. Cysneiros, A. Martinho, C. Reis, R.P. Penque, Deborah Pinto, P. Bárbara, Cristina |
dc.subject.por.fl_str_mv |
Sleep Apnea Obstructive sleep apnea syndrome (OSAS) Biomarkers of Cardiovascular Platelet parameters Red cell parameters Determinantes da Saude e da Doença Apneia do Sono |
topic |
Sleep Apnea Obstructive sleep apnea syndrome (OSAS) Biomarkers of Cardiovascular Platelet parameters Red cell parameters Determinantes da Saude e da Doença Apneia do Sono |
description |
Obstructive sleep apnea syndrome (OSAS) is a systemic inflammatory disease associated with cardiovascular consequences. Red blood cell distribution width (RDW), mean platelet volume (MPV), and platelet distribution width (PDW) are recognized biomarkers of cardiovascular morbidity/mortality. Limited data is available on the association between these parameters and OSAS severity and the relationship with positive airway pressure therapy (PAP). In this prospective study of male OSAS patients we analyzed hematological data in order to evaluate their value in predicting OSAS severity, the relationship with sleep parameters, and their behavior under PAP. Seventy-three patients were included (mean age 46.5 years), of which 36 were mild (49.3%), 10 moderate (13.7%), and 27 severe (37%). The mean RDW increased significantly with OSAS severity and showed a positive correlation with respiratory disturbance index and hypoxemic burdens. Additionally, a group of 48 patients (mean age 47.2 years) were submitted to PAP. After six months, red blood cell count, hemoglobin, hematocrit, and platelet count showed a significant decrease (p < 0.0001; p < 0.0001; p = 0.001; p < 0.0001; respectively). Concerning OSAS severity, these parameters also significantly decreased in mild patients (p = 0.003; p = 0.043; p = 0.020; p = 0.014; respectively) but only hemoglobin, hematocrit, and platelet count decreased in severe cases (p < 0.0001; p = 0.008; p = 0.018; respectively). This study demonstrated an association between RDW values and OSAS severity. Moreover, red cell and platelet parameters changed significantly after PAP, supporting its cardiovascular protective effect. RDW may become a simple/inexpensive blood biomarker, making it useful in prioritizing OSAS patients waiting for polysomnography, and red cell and platelet parameters could be useful in PAP follow up. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-31 2017-01-31T00:00:00Z 2018-02-02T12:55:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/4920 |
url |
http://hdl.handle.net/10400.18/4920 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Rev Port Pneumol. 2017;23(2):71-78 0873-2159 10.1016/j.rppnen.2016.12.001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier/Sociedade Portuguesa de Pneumologia |
publisher.none.fl_str_mv |
Elsevier/Sociedade Portuguesa de Pneumologia |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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