Tuberculosis Infection in HIV Vs Non‐HIV Patients
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/4639 |
Resumo: | Objectives: Tuberculosis (TB) is the most common opportunistic infection and cause of mortality among people living with HIV, and it is possible that it may also influence the evolution of the HIV infection. We assessed the differences between HIV-positive and -negative people infected with TB. Methods: The present study is a cross-sectional retrospective study by electronic record revision. We included patients admitted to a tertiary hospital with a diagnosis of TB between 2011 and 2016, comparing those with HIV coinfection with non-HIV patients, according to demographic and clinical characteristics. Results: This study included 591 patients, of whom 32% were HIV-coinfected. HIV-TB patients were younger, with a predominance of male gender. Considering TB risk factors, there was a higher prevalence of homelessness and intravenous drug use in the HIV group. In the non-HIV group, direct contact with other patients with TB and immunosuppression were more prevalent. Relative to TB characteristics, the HIV-coinfected group presents with a higher prevalence of disseminated disease and a higher occurrence of previous TB infection. Cancer was the most frequent cause of immunosuppression in the HIV group and the number testing positive for TB via microbiological culture was lower. Assessment of microbiological resistance and in-hospital mortality showed similar numbers in both groups. Conclusions: There are few papers comparing clinical course of TB between HIV-infected and non-infected patients. Our study differs from others in the literature as we focused on a country with middling incidence of TB and further characterized the differences between HIV-infected and non-infected patients which can contribute to the management of these patients. |
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Tuberculosis Infection in HIV Vs Non‐HIV PatientsHCC MEDHSAC MEDHCC INFMaleFemaleHumansAntitubercular AgentsCoinfection* / drug therapyCross-Sectional StudiesHIV Infections* / complicationsHIV Infections* / epidemiologyRetrospective StudiesTuberculosis* / complicationsTuberculosis* / diagnosisTuberculosis* / epidemiologyObjectives: Tuberculosis (TB) is the most common opportunistic infection and cause of mortality among people living with HIV, and it is possible that it may also influence the evolution of the HIV infection. We assessed the differences between HIV-positive and -negative people infected with TB. Methods: The present study is a cross-sectional retrospective study by electronic record revision. We included patients admitted to a tertiary hospital with a diagnosis of TB between 2011 and 2016, comparing those with HIV coinfection with non-HIV patients, according to demographic and clinical characteristics. Results: This study included 591 patients, of whom 32% were HIV-coinfected. HIV-TB patients were younger, with a predominance of male gender. Considering TB risk factors, there was a higher prevalence of homelessness and intravenous drug use in the HIV group. In the non-HIV group, direct contact with other patients with TB and immunosuppression were more prevalent. Relative to TB characteristics, the HIV-coinfected group presents with a higher prevalence of disseminated disease and a higher occurrence of previous TB infection. Cancer was the most frequent cause of immunosuppression in the HIV group and the number testing positive for TB via microbiological culture was lower. Assessment of microbiological resistance and in-hospital mortality showed similar numbers in both groups. Conclusions: There are few papers comparing clinical course of TB between HIV-infected and non-infected patients. Our study differs from others in the literature as we focused on a country with middling incidence of TB and further characterized the differences between HIV-infected and non-infected patients which can contribute to the management of these patients.WileyRepositório do Centro Hospitalar Universitário de Lisboa Central, EPERego de Figueiredo, IBranco Ferrão, JDias, SVieira Alves, RDrummond Borges, DTorres, MGuerreiro Castro, SLourenço, FAntunes, AMGruner, HPanarra, A2023-08-11T14:16:58Z2021-092021-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/4639engHIV Med . 2021 Sep;22(8):775-77910.1111/hiv.13119info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-13T06:03:20Zoai:repositorio.chlc.min-saude.pt:10400.17/4639Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:26:58.157557Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Tuberculosis Infection in HIV Vs Non‐HIV Patients |
title |
Tuberculosis Infection in HIV Vs Non‐HIV Patients |
spellingShingle |
Tuberculosis Infection in HIV Vs Non‐HIV Patients Rego de Figueiredo, I HCC MED HSAC MED HCC INF Male Female Humans Antitubercular Agents Coinfection* / drug therapy Cross-Sectional Studies HIV Infections* / complications HIV Infections* / epidemiology Retrospective Studies Tuberculosis* / complications Tuberculosis* / diagnosis Tuberculosis* / epidemiology |
title_short |
Tuberculosis Infection in HIV Vs Non‐HIV Patients |
title_full |
Tuberculosis Infection in HIV Vs Non‐HIV Patients |
title_fullStr |
Tuberculosis Infection in HIV Vs Non‐HIV Patients |
title_full_unstemmed |
Tuberculosis Infection in HIV Vs Non‐HIV Patients |
title_sort |
Tuberculosis Infection in HIV Vs Non‐HIV Patients |
author |
Rego de Figueiredo, I |
author_facet |
Rego de Figueiredo, I Branco Ferrão, J Dias, S Vieira Alves, R Drummond Borges, D Torres, M Guerreiro Castro, S Lourenço, F Antunes, AM Gruner, H Panarra, A |
author_role |
author |
author2 |
Branco Ferrão, J Dias, S Vieira Alves, R Drummond Borges, D Torres, M Guerreiro Castro, S Lourenço, F Antunes, AM Gruner, H Panarra, A |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Rego de Figueiredo, I Branco Ferrão, J Dias, S Vieira Alves, R Drummond Borges, D Torres, M Guerreiro Castro, S Lourenço, F Antunes, AM Gruner, H Panarra, A |
dc.subject.por.fl_str_mv |
HCC MED HSAC MED HCC INF Male Female Humans Antitubercular Agents Coinfection* / drug therapy Cross-Sectional Studies HIV Infections* / complications HIV Infections* / epidemiology Retrospective Studies Tuberculosis* / complications Tuberculosis* / diagnosis Tuberculosis* / epidemiology |
topic |
HCC MED HSAC MED HCC INF Male Female Humans Antitubercular Agents Coinfection* / drug therapy Cross-Sectional Studies HIV Infections* / complications HIV Infections* / epidemiology Retrospective Studies Tuberculosis* / complications Tuberculosis* / diagnosis Tuberculosis* / epidemiology |
description |
Objectives: Tuberculosis (TB) is the most common opportunistic infection and cause of mortality among people living with HIV, and it is possible that it may also influence the evolution of the HIV infection. We assessed the differences between HIV-positive and -negative people infected with TB. Methods: The present study is a cross-sectional retrospective study by electronic record revision. We included patients admitted to a tertiary hospital with a diagnosis of TB between 2011 and 2016, comparing those with HIV coinfection with non-HIV patients, according to demographic and clinical characteristics. Results: This study included 591 patients, of whom 32% were HIV-coinfected. HIV-TB patients were younger, with a predominance of male gender. Considering TB risk factors, there was a higher prevalence of homelessness and intravenous drug use in the HIV group. In the non-HIV group, direct contact with other patients with TB and immunosuppression were more prevalent. Relative to TB characteristics, the HIV-coinfected group presents with a higher prevalence of disseminated disease and a higher occurrence of previous TB infection. Cancer was the most frequent cause of immunosuppression in the HIV group and the number testing positive for TB via microbiological culture was lower. Assessment of microbiological resistance and in-hospital mortality showed similar numbers in both groups. Conclusions: There are few papers comparing clinical course of TB between HIV-infected and non-infected patients. Our study differs from others in the literature as we focused on a country with middling incidence of TB and further characterized the differences between HIV-infected and non-infected patients which can contribute to the management of these patients. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-09 2021-09-01T00:00:00Z 2023-08-11T14:16:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/4639 |
url |
http://hdl.handle.net/10400.17/4639 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
HIV Med . 2021 Sep;22(8):775-779 10.1111/hiv.13119 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133538633646080 |