Biomimetic materials assembled on a photovoltaic cell as a novel biosensing approach to cancer biomarker detection

Detalhes bibliográficos
Autor(a) principal: Moreira, Felismina
Data de Publicação: 2018
Outros Autores: Truta, Liliana, Sales, M. G. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/61837
Resumo: Supplementary information accompanies this paper at https://doi.org/10.1038/s41598-018-27884-2.
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spelling Biomimetic materials assembled on a photovoltaic cell as a novel biosensing approach to cancer biomarker detectionSupplementary information accompanies this paper at https://doi.org/10.1038/s41598-018-27884-2.This work describes for the first time the integration of Dye Sensitized Solar Cell (DSSC) technology in biosensors and biomimetic materials, opening doors towards a new dimension of autonomous screening devices that may be used in point-of-care, with zero-power requirements. DSSCs are fabricated with a counter electrode (CE) of polypyrrole (PPy) that was made responsive to a specific protein by biomimetic material (BM) technology. Carcinogenic embryonic antigen (CEA) was selected as target protein. The resulting BM-PPy film acted as biomimetic artificial antibody for CEA. Rebinding of CEA into this film changed its intrinsic electrical properties and the subsequent electrical output of the DSSC using it as CE. The quantity of CEA in solution was deduced by I-V and electrochemical impedance spesctroscopy (EIS). Linear responses to CEA were observed down to 0.25pg/mL, with 0.13pg/mL detection limit. Control films of PPy (prepared without CEA in the electropolymerization step) confirmed the ability of the BM material to recognize the target protein. Accurate results were obtained in the analysis of urine samples. Further developments into this ground-breaking self-powered biosensor will display a huge impact in point-to-care medical applications, which may be extended to other fields of knowledge.The authors acknowledge the financial support of FP7 and European Research Council though the Starting Grant, ERC-StG-3P’s/2012, GA 311086 (to MGF Sales).info:eu-repo/semantics/publishedVersionNature ResearchUniversidade do MinhoMoreira, FelisminaTruta, LilianaSales, M. G. F.20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/61837engMoreira, Felismina; Truta, Liliana; Sales, M. G. F., Biomimetic materials assembled on a photovoltaic cell as a novel biosensing approach to cancer biomarker detection. Scientific Reports, 8(10205), 2018.2045-232210.1038/s41598-018-27884-2http://www.nature.com/srep/index.htmlinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:25:12Zoai:repositorium.sdum.uminho.pt:1822/61837Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:19:24.329775Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Biomimetic materials assembled on a photovoltaic cell as a novel biosensing approach to cancer biomarker detection
title Biomimetic materials assembled on a photovoltaic cell as a novel biosensing approach to cancer biomarker detection
spellingShingle Biomimetic materials assembled on a photovoltaic cell as a novel biosensing approach to cancer biomarker detection
Moreira, Felismina
title_short Biomimetic materials assembled on a photovoltaic cell as a novel biosensing approach to cancer biomarker detection
title_full Biomimetic materials assembled on a photovoltaic cell as a novel biosensing approach to cancer biomarker detection
title_fullStr Biomimetic materials assembled on a photovoltaic cell as a novel biosensing approach to cancer biomarker detection
title_full_unstemmed Biomimetic materials assembled on a photovoltaic cell as a novel biosensing approach to cancer biomarker detection
title_sort Biomimetic materials assembled on a photovoltaic cell as a novel biosensing approach to cancer biomarker detection
author Moreira, Felismina
author_facet Moreira, Felismina
Truta, Liliana
Sales, M. G. F.
author_role author
author2 Truta, Liliana
Sales, M. G. F.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Moreira, Felismina
Truta, Liliana
Sales, M. G. F.
description Supplementary information accompanies this paper at https://doi.org/10.1038/s41598-018-27884-2.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/61837
url http://hdl.handle.net/1822/61837
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Moreira, Felismina; Truta, Liliana; Sales, M. G. F., Biomimetic materials assembled on a photovoltaic cell as a novel biosensing approach to cancer biomarker detection. Scientific Reports, 8(10205), 2018.
2045-2322
10.1038/s41598-018-27884-2
http://www.nature.com/srep/index.html
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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