Boundaries of a Systemic Disease: a Protean Presentation of Giant Cell Arteritis

Detalhes bibliográficos
Autor(a) principal: Mesquita, A
Data de Publicação: 2020
Outros Autores: Camara, L, Patrício, C, Brotas, V
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/3926
Resumo: A 60-year-old man was hospitalised with persistent fever, arm pain, dry cough and cholestasis. Diagnostic workup was remarkable for elevated inflammatory markers. Infectious diseases and autoimmune screening were negative. Imaging modalities excluded a neoplastic aetiology. Liver biopsy was negative for granulomatous or lymphomatous infiltrations. Giant cell arteritis (GCA) was suspected, but temporal artery Doppler ultrasound and biopsy were non-diagnostic. A positron emission tomography scan showed intense metabolic uptake in large vessels suggesting the diagnosis of GCA. Prednisolone was initiated with clinical and analytical improvement. At 1-year follow-up, there were no relapses and the patient remains symptom free.
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spelling Boundaries of a Systemic Disease: a Protean Presentation of Giant Cell ArteritisHSAC MEDMaleHumansMiddle AgedAnti-Inflammatory Agents, Non-SteroidalAspirin / therapeutic use*CholestasisCoughDiagnosis, DifferentialDrug Therapy, CombinationFever of Unknown OriginGiant Cell Arteritis / diagnostic imaging*Giant Cell Arteritis / drug therapy*Glucocorticoids / therapeutic usePositron-Emission TomographyPrednisolone / therapeutic use*A 60-year-old man was hospitalised with persistent fever, arm pain, dry cough and cholestasis. Diagnostic workup was remarkable for elevated inflammatory markers. Infectious diseases and autoimmune screening were negative. Imaging modalities excluded a neoplastic aetiology. Liver biopsy was negative for granulomatous or lymphomatous infiltrations. Giant cell arteritis (GCA) was suspected, but temporal artery Doppler ultrasound and biopsy were non-diagnostic. A positron emission tomography scan showed intense metabolic uptake in large vessels suggesting the diagnosis of GCA. Prednisolone was initiated with clinical and analytical improvement. At 1-year follow-up, there were no relapses and the patient remains symptom free.BMJRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEMesquita, ACamara, LPatrício, CBrotas, V2021-11-24T16:23:34Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/3926engBMJ Case Rep. 2020 Mar 25;13(3):e232234.10.1136/bcr-2019-232234.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:44:38Zoai:repositorio.chlc.min-saude.pt:10400.17/3926Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:21:14.098776Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Boundaries of a Systemic Disease: a Protean Presentation of Giant Cell Arteritis
title Boundaries of a Systemic Disease: a Protean Presentation of Giant Cell Arteritis
spellingShingle Boundaries of a Systemic Disease: a Protean Presentation of Giant Cell Arteritis
Mesquita, A
HSAC MED
Male
Humans
Middle Aged
Anti-Inflammatory Agents, Non-Steroidal
Aspirin / therapeutic use*
Cholestasis
Cough
Diagnosis, Differential
Drug Therapy, Combination
Fever of Unknown Origin
Giant Cell Arteritis / diagnostic imaging*
Giant Cell Arteritis / drug therapy*
Glucocorticoids / therapeutic use
Positron-Emission Tomography
Prednisolone / therapeutic use*
title_short Boundaries of a Systemic Disease: a Protean Presentation of Giant Cell Arteritis
title_full Boundaries of a Systemic Disease: a Protean Presentation of Giant Cell Arteritis
title_fullStr Boundaries of a Systemic Disease: a Protean Presentation of Giant Cell Arteritis
title_full_unstemmed Boundaries of a Systemic Disease: a Protean Presentation of Giant Cell Arteritis
title_sort Boundaries of a Systemic Disease: a Protean Presentation of Giant Cell Arteritis
author Mesquita, A
author_facet Mesquita, A
Camara, L
Patrício, C
Brotas, V
author_role author
author2 Camara, L
Patrício, C
Brotas, V
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Mesquita, A
Camara, L
Patrício, C
Brotas, V
dc.subject.por.fl_str_mv HSAC MED
Male
Humans
Middle Aged
Anti-Inflammatory Agents, Non-Steroidal
Aspirin / therapeutic use*
Cholestasis
Cough
Diagnosis, Differential
Drug Therapy, Combination
Fever of Unknown Origin
Giant Cell Arteritis / diagnostic imaging*
Giant Cell Arteritis / drug therapy*
Glucocorticoids / therapeutic use
Positron-Emission Tomography
Prednisolone / therapeutic use*
topic HSAC MED
Male
Humans
Middle Aged
Anti-Inflammatory Agents, Non-Steroidal
Aspirin / therapeutic use*
Cholestasis
Cough
Diagnosis, Differential
Drug Therapy, Combination
Fever of Unknown Origin
Giant Cell Arteritis / diagnostic imaging*
Giant Cell Arteritis / drug therapy*
Glucocorticoids / therapeutic use
Positron-Emission Tomography
Prednisolone / therapeutic use*
description A 60-year-old man was hospitalised with persistent fever, arm pain, dry cough and cholestasis. Diagnostic workup was remarkable for elevated inflammatory markers. Infectious diseases and autoimmune screening were negative. Imaging modalities excluded a neoplastic aetiology. Liver biopsy was negative for granulomatous or lymphomatous infiltrations. Giant cell arteritis (GCA) was suspected, but temporal artery Doppler ultrasound and biopsy were non-diagnostic. A positron emission tomography scan showed intense metabolic uptake in large vessels suggesting the diagnosis of GCA. Prednisolone was initiated with clinical and analytical improvement. At 1-year follow-up, there were no relapses and the patient remains symptom free.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2021-11-24T16:23:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/3926
url http://hdl.handle.net/10400.17/3926
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv BMJ Case Rep. 2020 Mar 25;13(3):e232234.
10.1136/bcr-2019-232234.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMJ
publisher.none.fl_str_mv BMJ
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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