Molecular Mechanisms for Adhesion and Colonization of Human Gastric Mucosa by Helicobacter pylori and its Clinical Implications
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6651 |
Resumo: | Introduction: Helicobacter pylori infection is very prevalent worldwide and is associated with the progression of the gastriccarcinogenesis cascade, being one of the main risk factors for the development of gastric carcinoma. Several factors are determinant for the infection and for the development of gastric disease, including environmental factors, host genetic factors and virulence factors of the bacteria.Material and Methods: In this review, we present an overview of the current knowledge on the determinants of the infection and on the recently described molecular mechanisms of Helicobacter pylori adhesion to the gastric mucosa, as well as its possible future therapeutic application.Results: The adhesion of Helicobacter pylori to the gastric epithelium is critical for gastric pathogenesis, allowing bacterial access to nutrients and the action of bacterial virulence factors, promoting recurrence of the infection and the progression of the gastric carcinogenesis pathway.Discussion: Eradication of Helicobacter pylori infection is the best preventive strategy available against gastric cancer, mainly if it is achieved before the development of pre-neoplastic lesions. The increase in antibiotics resistance, together with the eradication failures in some patients, has promoted the development of alternative treatments.Conclusion: The new therapeutic strategies, focused on the molecular mechanism of Helicobacter pylori adhesion, are very promising; however, future studies are needed to evaluate its in vivo efficiency and toxicity. |
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Molecular Mechanisms for Adhesion and Colonization of Human Gastric Mucosa by Helicobacter pylori and its Clinical ImplicationsMecanismos Moleculares de Adesão e Colonização da Mucosa Gástrica pela Helicobacter pylori e suas Implicações ClínicasAdhesinsBacterialCarcinogenesisHelicobacter InfectionsHelicobacter pyloriStomach NeoplasmsVirulence Factors.Adesinas BacterianasCarcinogéneseFactores de VirulênciaHelicobacter pyloriInfecções por HelicobacterNeoplasias Gástricas.Introduction: Helicobacter pylori infection is very prevalent worldwide and is associated with the progression of the gastriccarcinogenesis cascade, being one of the main risk factors for the development of gastric carcinoma. Several factors are determinant for the infection and for the development of gastric disease, including environmental factors, host genetic factors and virulence factors of the bacteria.Material and Methods: In this review, we present an overview of the current knowledge on the determinants of the infection and on the recently described molecular mechanisms of Helicobacter pylori adhesion to the gastric mucosa, as well as its possible future therapeutic application.Results: The adhesion of Helicobacter pylori to the gastric epithelium is critical for gastric pathogenesis, allowing bacterial access to nutrients and the action of bacterial virulence factors, promoting recurrence of the infection and the progression of the gastric carcinogenesis pathway.Discussion: Eradication of Helicobacter pylori infection is the best preventive strategy available against gastric cancer, mainly if it is achieved before the development of pre-neoplastic lesions. The increase in antibiotics resistance, together with the eradication failures in some patients, has promoted the development of alternative treatments.Conclusion: The new therapeutic strategies, focused on the molecular mechanism of Helicobacter pylori adhesion, are very promising; however, future studies are needed to evaluate its in vivo efficiency and toxicity.Introdução: A infeção por Helicobacter pylori é muito prevalente mundialmente, e está associada à progressão da cascata de carcinogénese gástrica, sendo um dos principais fatores de risco para o desenvolvimento de carcinoma gástrico. São vários os fatores determinantes para a infeção e desenvolvimento de patologia gástrica, incluindo fatores ambientais, fatores genéticos do hospedeiro, e fatores de virulência da bactéria.Material e Métodos: Neste trabalho, é apresentada uma revisão do estado da arte sobre os fatores determinantes da infeção e sobre os mecanismos moleculares de adesão da Helicobacter pylori à mucosa gástrica recentemente descritos e a sua possível aplicação terapêutica.Resultados: A adesão da Helicobacter pylori ao epitélio gástrico é uma etapa fundamental da patogénese gástrica, permitindo o acesso da bactéria a nutrientes, e a ação de diversos fatores de virulência da bactéria, promovendo, desta forma, a recorrência da infeção e a progressão na cascata de carcinogénese gástrica.Discussão: A erradicação da infeção por Helicobacter pylori é a melhor estratégia preventiva disponível contra o carcinoma gástrico, principalmente quando feita antes do aparecimento de lesões pré-neoplásicas. O aumento da resistência aos antibacterianos e as taxas de erradicação, por vezes aquém do esperado, contribuem para a procura de alternativas de tratamento.Conclusão: O desenvolvimento de novas estratégias terapêuticas focadas nos mecanismos moleculares de adesão da Helicobacter pylori é muito promissor, no entanto são necessários estudos futuros sobre a sua eficácia in vivo e toxicidade.Ordem dos Médicos2016-08-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfimage/jpegimage/jpegapplication/mswordapplication/mswordimage/jpegimage/jpegapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6651oai:ojs.www.actamedicaportuguesa.com:article/6651Acta Médica Portuguesa; Vol. 29 No. 7-8 (2016): July-August; 476-483Acta Médica Portuguesa; Vol. 29 N.º 7-8 (2016): Julho-Agosto; 476-4831646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6651https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6651/4734https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6651/7705https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6651/7706https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6651/7707https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6651/8129https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6651/8130https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6651/8131https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6651/8427Direitos de Autor (c) 2016 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessCoelho, ElisabeteMagalhães, AnaDinis-Ribeiro, MárioReis, Celso A.2022-12-20T11:04:55Zoai:ojs.www.actamedicaportuguesa.com:article/6651Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:20.741574Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Molecular Mechanisms for Adhesion and Colonization of Human Gastric Mucosa by Helicobacter pylori and its Clinical Implications Mecanismos Moleculares de Adesão e Colonização da Mucosa Gástrica pela Helicobacter pylori e suas Implicações Clínicas |
title |
Molecular Mechanisms for Adhesion and Colonization of Human Gastric Mucosa by Helicobacter pylori and its Clinical Implications |
spellingShingle |
Molecular Mechanisms for Adhesion and Colonization of Human Gastric Mucosa by Helicobacter pylori and its Clinical Implications Coelho, Elisabete Adhesins Bacterial Carcinogenesis Helicobacter Infections Helicobacter pylori Stomach Neoplasms Virulence Factors. Adesinas Bacterianas Carcinogénese Factores de Virulência Helicobacter pylori Infecções por Helicobacter Neoplasias Gástricas. |
title_short |
Molecular Mechanisms for Adhesion and Colonization of Human Gastric Mucosa by Helicobacter pylori and its Clinical Implications |
title_full |
Molecular Mechanisms for Adhesion and Colonization of Human Gastric Mucosa by Helicobacter pylori and its Clinical Implications |
title_fullStr |
Molecular Mechanisms for Adhesion and Colonization of Human Gastric Mucosa by Helicobacter pylori and its Clinical Implications |
title_full_unstemmed |
Molecular Mechanisms for Adhesion and Colonization of Human Gastric Mucosa by Helicobacter pylori and its Clinical Implications |
title_sort |
Molecular Mechanisms for Adhesion and Colonization of Human Gastric Mucosa by Helicobacter pylori and its Clinical Implications |
author |
Coelho, Elisabete |
author_facet |
Coelho, Elisabete Magalhães, Ana Dinis-Ribeiro, Mário Reis, Celso A. |
author_role |
author |
author2 |
Magalhães, Ana Dinis-Ribeiro, Mário Reis, Celso A. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Coelho, Elisabete Magalhães, Ana Dinis-Ribeiro, Mário Reis, Celso A. |
dc.subject.por.fl_str_mv |
Adhesins Bacterial Carcinogenesis Helicobacter Infections Helicobacter pylori Stomach Neoplasms Virulence Factors. Adesinas Bacterianas Carcinogénese Factores de Virulência Helicobacter pylori Infecções por Helicobacter Neoplasias Gástricas. |
topic |
Adhesins Bacterial Carcinogenesis Helicobacter Infections Helicobacter pylori Stomach Neoplasms Virulence Factors. Adesinas Bacterianas Carcinogénese Factores de Virulência Helicobacter pylori Infecções por Helicobacter Neoplasias Gástricas. |
description |
Introduction: Helicobacter pylori infection is very prevalent worldwide and is associated with the progression of the gastriccarcinogenesis cascade, being one of the main risk factors for the development of gastric carcinoma. Several factors are determinant for the infection and for the development of gastric disease, including environmental factors, host genetic factors and virulence factors of the bacteria.Material and Methods: In this review, we present an overview of the current knowledge on the determinants of the infection and on the recently described molecular mechanisms of Helicobacter pylori adhesion to the gastric mucosa, as well as its possible future therapeutic application.Results: The adhesion of Helicobacter pylori to the gastric epithelium is critical for gastric pathogenesis, allowing bacterial access to nutrients and the action of bacterial virulence factors, promoting recurrence of the infection and the progression of the gastric carcinogenesis pathway.Discussion: Eradication of Helicobacter pylori infection is the best preventive strategy available against gastric cancer, mainly if it is achieved before the development of pre-neoplastic lesions. The increase in antibiotics resistance, together with the eradication failures in some patients, has promoted the development of alternative treatments.Conclusion: The new therapeutic strategies, focused on the molecular mechanism of Helicobacter pylori adhesion, are very promising; however, future studies are needed to evaluate its in vivo efficiency and toxicity. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-08-31 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6651 oai:ojs.www.actamedicaportuguesa.com:article/6651 |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6651 |
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oai:ojs.www.actamedicaportuguesa.com:article/6651 |
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por |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6651 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6651/4734 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6651/7705 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6651/7706 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6651/7707 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6651/8129 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6651/8130 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6651/8131 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6651/8427 |
dc.rights.driver.fl_str_mv |
Direitos de Autor (c) 2016 Acta Médica Portuguesa info:eu-repo/semantics/openAccess |
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Direitos de Autor (c) 2016 Acta Médica Portuguesa |
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openAccess |
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Ordem dos Médicos |
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Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 29 No. 7-8 (2016): July-August; 476-483 Acta Médica Portuguesa; Vol. 29 N.º 7-8 (2016): Julho-Agosto; 476-483 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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