The effects of long-term chaetomellic acid a administration on renal function and oxidative stress in a rat model of renal mass reduction
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/15506 |
Resumo: | This study aimed to evaluate the effect of chronic treatment with chaetomellic acid A (CAA) on oxidative stress and renal function in amodel of renalmass reduction. Methods.MaleWistar ratswere subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats have been divided into four experimental groups: RMR: RMR rats without treatment (n = 14); RMR + CAA: RMR rats treated with CAA (n = 13); SO: SO rats without treatment (n = 13); and SO + CAA: SO rats treated with CAA (n = 13). CAA was intraperitoneally administered in a dose of 0.23 μg/Kg three times a week for six months. Results. RMR was accompanied by a significant reduction in catalase and glutathione reductase (GR) activity (p < 0.05) and a decrease in reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio. CAAadministration significantly increased catalase andGR activity (p < 0.05) and increased GSH/GSSG ratio, but no significant difference between the treated and nontreated groups was found in this ratio.No significant differences were found between theRMRgroups in any of the parameters of renal function.However, CAA administration slightly improves some parameters of renal function. Conclusions. These data suggest that CAA could attenuate 5/6 RMR-induced oxidative stress. |
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The effects of long-term chaetomellic acid a administration on renal function and oxidative stress in a rat model of renal mass reductionThis study aimed to evaluate the effect of chronic treatment with chaetomellic acid A (CAA) on oxidative stress and renal function in amodel of renalmass reduction. Methods.MaleWistar ratswere subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats have been divided into four experimental groups: RMR: RMR rats without treatment (n = 14); RMR + CAA: RMR rats treated with CAA (n = 13); SO: SO rats without treatment (n = 13); and SO + CAA: SO rats treated with CAA (n = 13). CAA was intraperitoneally administered in a dose of 0.23 μg/Kg three times a week for six months. Results. RMR was accompanied by a significant reduction in catalase and glutathione reductase (GR) activity (p < 0.05) and a decrease in reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio. CAAadministration significantly increased catalase andGR activity (p < 0.05) and increased GSH/GSSG ratio, but no significant difference between the treated and nontreated groups was found in this ratio.No significant differences were found between theRMRgroups in any of the parameters of renal function.However, CAA administration slightly improves some parameters of renal function. Conclusions. These data suggest that CAA could attenuate 5/6 RMR-induced oxidative stress.The authors would like to thank Jos´e Miguel Lopez- Novoa for valuable comments and suggestions. This work is supported by European Investment Funds by FEDER/ COMPETE/POCI, Operational Competitiveness and Internationalization Programme, under Project POCI-01-0145- FEDER-006958, and National Funds by FCT, Portuguese Foundation for Science and Technology, under Project UID/AGR/04033/2013, and by European Investment Funds by FEDER/COMPETE/POCI, Operational Competitiveness and Internationalization Programme, under Project POCI- 01-0145-FEDER-016728, and National Funds by FCT, Portuguese Foundation for Science and Technology, under Project PTDC/DTP-DES/6077/2014.Biblioteca Digital do IPBNogueira, António José M.Peixoto, Francisco P.Oliveira, Maria ManuelPires, Carlos AndréColaço, Bruno JorgeOliveira, Paula A.Pires, Maria João2018-01-25T10:00:00Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/15506engNogueira, António; Peixoto, Francisco; Oliveira, Maria Manuel; Pires, Carlos André; Colaço, Bruno; Oliveira, Paula Alexandra; Pires, Maria João (2017). The effects of long-term chaetomellic acid a administration on renal function and oxidative stress in a rat model of renal mass reduction. BioMed Research International. ISSN 2314-6133. 2017, p.2314-613310.1155/2017/5125980info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-24T01:18:51Zoai:bibliotecadigital.ipb.pt:10198/15506Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:05:02.244400Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The effects of long-term chaetomellic acid a administration on renal function and oxidative stress in a rat model of renal mass reduction |
title |
The effects of long-term chaetomellic acid a administration on renal function and oxidative stress in a rat model of renal mass reduction |
spellingShingle |
The effects of long-term chaetomellic acid a administration on renal function and oxidative stress in a rat model of renal mass reduction Nogueira, António José M. |
title_short |
The effects of long-term chaetomellic acid a administration on renal function and oxidative stress in a rat model of renal mass reduction |
title_full |
The effects of long-term chaetomellic acid a administration on renal function and oxidative stress in a rat model of renal mass reduction |
title_fullStr |
The effects of long-term chaetomellic acid a administration on renal function and oxidative stress in a rat model of renal mass reduction |
title_full_unstemmed |
The effects of long-term chaetomellic acid a administration on renal function and oxidative stress in a rat model of renal mass reduction |
title_sort |
The effects of long-term chaetomellic acid a administration on renal function and oxidative stress in a rat model of renal mass reduction |
author |
Nogueira, António José M. |
author_facet |
Nogueira, António José M. Peixoto, Francisco P. Oliveira, Maria Manuel Pires, Carlos André Colaço, Bruno Jorge Oliveira, Paula A. Pires, Maria João |
author_role |
author |
author2 |
Peixoto, Francisco P. Oliveira, Maria Manuel Pires, Carlos André Colaço, Bruno Jorge Oliveira, Paula A. Pires, Maria João |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Nogueira, António José M. Peixoto, Francisco P. Oliveira, Maria Manuel Pires, Carlos André Colaço, Bruno Jorge Oliveira, Paula A. Pires, Maria João |
description |
This study aimed to evaluate the effect of chronic treatment with chaetomellic acid A (CAA) on oxidative stress and renal function in amodel of renalmass reduction. Methods.MaleWistar ratswere subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats have been divided into four experimental groups: RMR: RMR rats without treatment (n = 14); RMR + CAA: RMR rats treated with CAA (n = 13); SO: SO rats without treatment (n = 13); and SO + CAA: SO rats treated with CAA (n = 13). CAA was intraperitoneally administered in a dose of 0.23 μg/Kg three times a week for six months. Results. RMR was accompanied by a significant reduction in catalase and glutathione reductase (GR) activity (p < 0.05) and a decrease in reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio. CAAadministration significantly increased catalase andGR activity (p < 0.05) and increased GSH/GSSG ratio, but no significant difference between the treated and nontreated groups was found in this ratio.No significant differences were found between theRMRgroups in any of the parameters of renal function.However, CAA administration slightly improves some parameters of renal function. Conclusions. These data suggest that CAA could attenuate 5/6 RMR-induced oxidative stress. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z 2018-01-25T10:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/15506 |
url |
http://hdl.handle.net/10198/15506 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Nogueira, António; Peixoto, Francisco; Oliveira, Maria Manuel; Pires, Carlos André; Colaço, Bruno; Oliveira, Paula Alexandra; Pires, Maria João (2017). The effects of long-term chaetomellic acid a administration on renal function and oxidative stress in a rat model of renal mass reduction. BioMed Research International. ISSN 2314-6133. 2017, p. 2314-6133 10.1155/2017/5125980 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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