Interleukin-10: a key cytokine in depression?

Detalhes bibliográficos
Autor(a) principal: Roque, Susana
Data de Publicação: 2009
Outros Autores: Neves, Margarida Correia, Mesquita, Ana Raquel Marcelino, Palha, Joana Almeida, Sousa, Nuno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/29729
Resumo: An increasing body of evidence implicates proinflammatory cytokines in psychiatric disorders, namely, in depression. Of notice, recent studies showed that anti-inflammatory cytokines, such as IL-10, also modulate depressive-like behavior. In this article, we propose that the anti-inflammatory cytokine IL-10 is a putative link between two of the most widely reported phenomenon observed in depressed patients: the disruption of the hypothalamic-pituitary-adrenal axis and the imbalanced production of cytokines. If so, IL-10 might represent a novel target for antidepressant therapy.
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spelling Interleukin-10: a key cytokine in depression?An increasing body of evidence implicates proinflammatory cytokines in psychiatric disorders, namely, in depression. Of notice, recent studies showed that anti-inflammatory cytokines, such as IL-10, also modulate depressive-like behavior. In this article, we propose that the anti-inflammatory cytokine IL-10 is a putative link between two of the most widely reported phenomenon observed in depressed patients: the disruption of the hypothalamic-pituitary-adrenal axis and the imbalanced production of cytokines. If so, IL-10 might represent a novel target for antidepressant therapy.The authors acknowledge the Portuguese Foundation for Science and Technology (FCT) for providing a fellowship to Roque S. (SFRH/BD/24539/2005). This work was supported by a Grant from FCT (PTDC/SAU-NEU/72699/2006).Hindawi Publishing CorporationUniversidade do MinhoRoque, SusanaNeves, Margarida CorreiaMesquita, Ana Raquel MarcelinoPalha, Joana AlmeidaSousa, Nuno20092009-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/29729eng2090-016310.1155/2009/187894http://www.hindawi.com/journals/cpn/2009/187894/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:58:04Zoai:repositorium.sdum.uminho.pt:1822/29729Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:47:45.559069Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Interleukin-10: a key cytokine in depression?
title Interleukin-10: a key cytokine in depression?
spellingShingle Interleukin-10: a key cytokine in depression?
Roque, Susana
title_short Interleukin-10: a key cytokine in depression?
title_full Interleukin-10: a key cytokine in depression?
title_fullStr Interleukin-10: a key cytokine in depression?
title_full_unstemmed Interleukin-10: a key cytokine in depression?
title_sort Interleukin-10: a key cytokine in depression?
author Roque, Susana
author_facet Roque, Susana
Neves, Margarida Correia
Mesquita, Ana Raquel Marcelino
Palha, Joana Almeida
Sousa, Nuno
author_role author
author2 Neves, Margarida Correia
Mesquita, Ana Raquel Marcelino
Palha, Joana Almeida
Sousa, Nuno
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Roque, Susana
Neves, Margarida Correia
Mesquita, Ana Raquel Marcelino
Palha, Joana Almeida
Sousa, Nuno
description An increasing body of evidence implicates proinflammatory cytokines in psychiatric disorders, namely, in depression. Of notice, recent studies showed that anti-inflammatory cytokines, such as IL-10, also modulate depressive-like behavior. In this article, we propose that the anti-inflammatory cytokine IL-10 is a putative link between two of the most widely reported phenomenon observed in depressed patients: the disruption of the hypothalamic-pituitary-adrenal axis and the imbalanced production of cytokines. If so, IL-10 might represent a novel target for antidepressant therapy.
publishDate 2009
dc.date.none.fl_str_mv 2009
2009-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/29729
url http://hdl.handle.net/1822/29729
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2090-0163
10.1155/2009/187894
http://www.hindawi.com/journals/cpn/2009/187894/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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