HELICOBACTER PYLORI AND THE ATHEROGENIC PROCESS IN CARDIOVASCULAR DISEASE
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.48750/acv.105 |
Resumo: | Background: Conventional risk factors do not explain completely the atherogenic process. Chronic Helicobacter pylori (HP) infection may cause arterial inflammation and has been epidemiologically linked to the occurrence of atherosclerosis. Studies about the association of HP infection with peripheral arterial disease are limited. Objective: Evaluate the presence of HP using a monoclonal antibody anti-HP in the atherosclerotic plaques of the superficial femoral artery in patients submitted to amputation above-knee. Material and methods: We searched for the presence of HP in 29 non-consecutive patients with Leriche-Fontaine grade IV lower limb ischemia, submitted to amputation above-knee. Femoral artery was isolated and an atherosclerotic plaque specimen immediately distal to the amputation level, was removed, fixed in formalin and evaluated for HP, using a mono clonal antibody, anti-HP. Results: The mean age of the 29 patients was 82 years. 18 were men (62.1 %). Risk factors for cardiovascular disease were present in the majority of patients. Only one patient had known history of HP infection in the past. Morbidity rate was 30%. The mortality rate was 13.8 % (4 cases). In all cases, anti-HP showed no evidence of HP at the atherosclerotic plaque. Discussion/Conclusion: HP infection has been associated both epidemiologically and pathogenetically with atherosclerosis. However, HP was not found in this study at the atherosclerotic plaques of the superficial femoral artery. |
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HELICOBACTER PYLORI AND THE ATHEROGENIC PROCESS IN CARDIOVASCULAR DISEASEHELICOBACTER PYLORI E O PROCESSO ATEROGÉNICO NA DOENÇA CARDIOVASCULARHelicobacter pyloriatherosclerosisarterial inflammationcardiovascular risk factorsHelicobacter pyloriateroscleroseinflamação arterialfactores de risco cardiovascularesBackground: Conventional risk factors do not explain completely the atherogenic process. Chronic Helicobacter pylori (HP) infection may cause arterial inflammation and has been epidemiologically linked to the occurrence of atherosclerosis. Studies about the association of HP infection with peripheral arterial disease are limited. Objective: Evaluate the presence of HP using a monoclonal antibody anti-HP in the atherosclerotic plaques of the superficial femoral artery in patients submitted to amputation above-knee. Material and methods: We searched for the presence of HP in 29 non-consecutive patients with Leriche-Fontaine grade IV lower limb ischemia, submitted to amputation above-knee. Femoral artery was isolated and an atherosclerotic plaque specimen immediately distal to the amputation level, was removed, fixed in formalin and evaluated for HP, using a mono clonal antibody, anti-HP. Results: The mean age of the 29 patients was 82 years. 18 were men (62.1 %). Risk factors for cardiovascular disease were present in the majority of patients. Only one patient had known history of HP infection in the past. Morbidity rate was 30%. The mortality rate was 13.8 % (4 cases). In all cases, anti-HP showed no evidence of HP at the atherosclerotic plaque. Discussion/Conclusion: HP infection has been associated both epidemiologically and pathogenetically with atherosclerosis. However, HP was not found in this study at the atherosclerotic plaques of the superficial femoral artery.Introdução: Os factores de risco cardiovasculares não explicam completamente o processo aterogénico. A infecção crónica a Helicobacter pylori (HP) poderá provocar inflamação arterial e está epidemiologicamente ligada ao processo de aterosclerose. Pouco se sabe sobre o papel do HP no processo de aterosclerose, os estudos sobre a associação entre a infecção a HP e doença arterial periférica são limitados. Objetivo: avaliar a presença de HP através de anticorpo monoclonal anti-HP em placas de aterosclerose da artéria femoral superficial de doentes submetidos a amputação acima do joelho. Material e métodos: Foi avaliada a presença de HP em 29 doentes não consecutivos com isquémia do membro inferior Leriche-Fontaine grau IV submetidos a amputação acima do joelho. Isolou-se a artéria femoral superficial e recolheu-se um fragmento de placa aterosclerótica imediatamente distal ao nível de amputação. O espécimen foi fixo em formol e avaliada a presença de HP utilizando um anticorpo monoclocal anti-HP. Resultados: A mediana da idade dos 29 doentes é 82 anos. 18 são do sexo masculino (62,1%). A maioria dos doentes apresentava factores de risco cardiovasculares. Apenas um doente tinha história pessoal de infecção a HP. A morbilidade foi de 30% e a mortalidade 13,8% (n=4). Não se verificou a presença de HP na placa aterosclerótica através do anticorpo monoclocal anti-HP. Discussão / Conclusão: A infecção a HP tem sido associada epidemiologicamente ao processo de aterosclerose. Contudo, neste estudo, não se identificou a presença de HP na placa de aterosclerose na artéria femoral superficial.Sociedade Portuguesa de Angiologia e Cirurgia Vascular2018-12-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.48750/acv.105oai:ojs.acvjournal.com:article/105Angiologia e Cirurgia Vascular; Vol. 14 No. 3 (2018): September; 182-185Angiologia e Cirurgia Vascular; Vol. 14 N.º 3 (2018): Setembro; 182-1852183-00961646-706Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://acvjournal.com/index.php/acv/article/view/105https://doi.org/10.48750/acv.105http://acvjournal.com/index.php/acv/article/view/105/105Copyright (c) 2018 Angiologia e Cirurgia Vascularinfo:eu-repo/semantics/openAccessCarvalho, NunoCóias, AnaCoelho, HélderMarcelino, GiselaAlbergaria, DiogoFerreira, Maria JoséBrito, Maria JoséCorte Real, JoãoMatos Costa, Paulo2022-05-23T15:10:01Zoai:ojs.acvjournal.com:article/105Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T14:57:30.408438Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
HELICOBACTER PYLORI AND THE ATHEROGENIC PROCESS IN CARDIOVASCULAR DISEASE HELICOBACTER PYLORI E O PROCESSO ATEROGÉNICO NA DOENÇA CARDIOVASCULAR |
title |
HELICOBACTER PYLORI AND THE ATHEROGENIC PROCESS IN CARDIOVASCULAR DISEASE |
spellingShingle |
HELICOBACTER PYLORI AND THE ATHEROGENIC PROCESS IN CARDIOVASCULAR DISEASE Carvalho, Nuno Helicobacter pylori atherosclerosis arterial inflammation cardiovascular risk factors Helicobacter pylori aterosclerose inflamação arterial factores de risco cardiovasculares |
title_short |
HELICOBACTER PYLORI AND THE ATHEROGENIC PROCESS IN CARDIOVASCULAR DISEASE |
title_full |
HELICOBACTER PYLORI AND THE ATHEROGENIC PROCESS IN CARDIOVASCULAR DISEASE |
title_fullStr |
HELICOBACTER PYLORI AND THE ATHEROGENIC PROCESS IN CARDIOVASCULAR DISEASE |
title_full_unstemmed |
HELICOBACTER PYLORI AND THE ATHEROGENIC PROCESS IN CARDIOVASCULAR DISEASE |
title_sort |
HELICOBACTER PYLORI AND THE ATHEROGENIC PROCESS IN CARDIOVASCULAR DISEASE |
author |
Carvalho, Nuno |
author_facet |
Carvalho, Nuno Cóias, Ana Coelho, Hélder Marcelino, Gisela Albergaria, Diogo Ferreira, Maria José Brito, Maria José Corte Real, João Matos Costa, Paulo |
author_role |
author |
author2 |
Cóias, Ana Coelho, Hélder Marcelino, Gisela Albergaria, Diogo Ferreira, Maria José Brito, Maria José Corte Real, João Matos Costa, Paulo |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Carvalho, Nuno Cóias, Ana Coelho, Hélder Marcelino, Gisela Albergaria, Diogo Ferreira, Maria José Brito, Maria José Corte Real, João Matos Costa, Paulo |
dc.subject.por.fl_str_mv |
Helicobacter pylori atherosclerosis arterial inflammation cardiovascular risk factors Helicobacter pylori aterosclerose inflamação arterial factores de risco cardiovasculares |
topic |
Helicobacter pylori atherosclerosis arterial inflammation cardiovascular risk factors Helicobacter pylori aterosclerose inflamação arterial factores de risco cardiovasculares |
description |
Background: Conventional risk factors do not explain completely the atherogenic process. Chronic Helicobacter pylori (HP) infection may cause arterial inflammation and has been epidemiologically linked to the occurrence of atherosclerosis. Studies about the association of HP infection with peripheral arterial disease are limited. Objective: Evaluate the presence of HP using a monoclonal antibody anti-HP in the atherosclerotic plaques of the superficial femoral artery in patients submitted to amputation above-knee. Material and methods: We searched for the presence of HP in 29 non-consecutive patients with Leriche-Fontaine grade IV lower limb ischemia, submitted to amputation above-knee. Femoral artery was isolated and an atherosclerotic plaque specimen immediately distal to the amputation level, was removed, fixed in formalin and evaluated for HP, using a mono clonal antibody, anti-HP. Results: The mean age of the 29 patients was 82 years. 18 were men (62.1 %). Risk factors for cardiovascular disease were present in the majority of patients. Only one patient had known history of HP infection in the past. Morbidity rate was 30%. The mortality rate was 13.8 % (4 cases). In all cases, anti-HP showed no evidence of HP at the atherosclerotic plaque. Discussion/Conclusion: HP infection has been associated both epidemiologically and pathogenetically with atherosclerosis. However, HP was not found in this study at the atherosclerotic plaques of the superficial femoral artery. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-21T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.48750/acv.105 oai:ojs.acvjournal.com:article/105 |
url |
https://doi.org/10.48750/acv.105 |
identifier_str_mv |
oai:ojs.acvjournal.com:article/105 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://acvjournal.com/index.php/acv/article/view/105 https://doi.org/10.48750/acv.105 http://acvjournal.com/index.php/acv/article/view/105/105 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Angiologia e Cirurgia Vascular info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Angiologia e Cirurgia Vascular |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Angiologia e Cirurgia Vascular |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Angiologia e Cirurgia Vascular |
dc.source.none.fl_str_mv |
Angiologia e Cirurgia Vascular; Vol. 14 No. 3 (2018): September; 182-185 Angiologia e Cirurgia Vascular; Vol. 14 N.º 3 (2018): Setembro; 182-185 2183-0096 1646-706X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799129848724062208 |