Antitumoral and antiangiogenic activity of Portuguese propolis in in vitro and in vivo models

Detalhes bibliográficos
Autor(a) principal: Carvalho, Ricardo Silva
Data de Publicação: 2014
Outros Autores: Gonçalves, Vera Mónica Miranda, Ferreira, Ana Margarida, Cardoso, Susana M., Sobral, Abílio J. F. N., Aguiar, Cristina, Baltazar, Fátima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/31677
Resumo: Propolis, a natural product, has important biological properties, however, studies with Portuguese propolis are scarce. Thus, we aimed to characterize the chemical composition and the antitumoural and antiangiogenic activities of a sample from Pereiro (Portugal). The chemical profile of our propolis sample (P10.EE) is similar to the poplar propolis type. P10.EE decreased cell viability of different tumour cells, being less cytotoxic against non-tumoural cells. P10.EE decreased MDA-MB-231 and DU145 cell proliferation and migration, with cell cycle changes and increased cell death. The increased glucose consumption and lactate production in MDA-MB-231 cells is explained by an increased expression of different metabolism-related proteins. P10.EE induced a decrease in HBMEC cells total biomass and proliferation and decreased vessel sprouting in the chicken chorioallantoic membrane. Additionally, P10.EE potentiates paclitaxel effect in MDA-MB-231 and DU145 cells. Concluding, P10.EE can be a good candidate for cancer drug development since it affects different characteristics that dictate tumorigenesis.
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spelling Antitumoral and antiangiogenic activity of Portuguese propolis in in vitro and in vivo modelsPortuguese propolisCancerAntitumoural activityAntiangiogenic activityCancer metabolismScience & TechnologyPropolis, a natural product, has important biological properties, however, studies with Portuguese propolis are scarce. Thus, we aimed to characterize the chemical composition and the antitumoural and antiangiogenic activities of a sample from Pereiro (Portugal). The chemical profile of our propolis sample (P10.EE) is similar to the poplar propolis type. P10.EE decreased cell viability of different tumour cells, being less cytotoxic against non-tumoural cells. P10.EE decreased MDA-MB-231 and DU145 cell proliferation and migration, with cell cycle changes and increased cell death. The increased glucose consumption and lactate production in MDA-MB-231 cells is explained by an increased expression of different metabolism-related proteins. P10.EE induced a decrease in HBMEC cells total biomass and proliferation and decreased vessel sprouting in the chicken chorioallantoic membrane. Additionally, P10.EE potentiates paclitaxel effect in MDA-MB-231 and DU145 cells. Concluding, P10.EE can be a good candidate for cancer drug development since it affects different characteristics that dictate tumorigenesis.This work was supported by the Life and Health Sciences Research Institute, University of Minho, Portugal, and Fundacao para a Ciencia e Tecnologia (FCT) (SFRH/BD/5199712012 to V.M.G.), through Fundo Europeu de Desenvolvimento Regional-QREN-COMPETE, projects PTDC/AAC-CLI1098308/2008 and PTDC/AAC-CLI/11809212010 and also CERNAS (project PEst-OE/AGR/UI0681/2011).ElsevierUniversidade do MinhoCarvalho, Ricardo SilvaGonçalves, Vera Mónica MirandaFerreira, Ana MargaridaCardoso, Susana M.Sobral, Abílio J. F. N.Aguiar, CristinaBaltazar, Fátima20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/31677eng1756-464610.1016/j.jff.2014.09.009http://www.journals.elsevier.com/journal-of-functional-foods/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:02:58Zoai:repositorium.sdum.uminho.pt:1822/31677Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:53:02.360361Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Antitumoral and antiangiogenic activity of Portuguese propolis in in vitro and in vivo models
title Antitumoral and antiangiogenic activity of Portuguese propolis in in vitro and in vivo models
spellingShingle Antitumoral and antiangiogenic activity of Portuguese propolis in in vitro and in vivo models
Carvalho, Ricardo Silva
Portuguese propolis
Cancer
Antitumoural activity
Antiangiogenic activity
Cancer metabolism
Science & Technology
title_short Antitumoral and antiangiogenic activity of Portuguese propolis in in vitro and in vivo models
title_full Antitumoral and antiangiogenic activity of Portuguese propolis in in vitro and in vivo models
title_fullStr Antitumoral and antiangiogenic activity of Portuguese propolis in in vitro and in vivo models
title_full_unstemmed Antitumoral and antiangiogenic activity of Portuguese propolis in in vitro and in vivo models
title_sort Antitumoral and antiangiogenic activity of Portuguese propolis in in vitro and in vivo models
author Carvalho, Ricardo Silva
author_facet Carvalho, Ricardo Silva
Gonçalves, Vera Mónica Miranda
Ferreira, Ana Margarida
Cardoso, Susana M.
Sobral, Abílio J. F. N.
Aguiar, Cristina
Baltazar, Fátima
author_role author
author2 Gonçalves, Vera Mónica Miranda
Ferreira, Ana Margarida
Cardoso, Susana M.
Sobral, Abílio J. F. N.
Aguiar, Cristina
Baltazar, Fátima
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Carvalho, Ricardo Silva
Gonçalves, Vera Mónica Miranda
Ferreira, Ana Margarida
Cardoso, Susana M.
Sobral, Abílio J. F. N.
Aguiar, Cristina
Baltazar, Fátima
dc.subject.por.fl_str_mv Portuguese propolis
Cancer
Antitumoural activity
Antiangiogenic activity
Cancer metabolism
Science & Technology
topic Portuguese propolis
Cancer
Antitumoural activity
Antiangiogenic activity
Cancer metabolism
Science & Technology
description Propolis, a natural product, has important biological properties, however, studies with Portuguese propolis are scarce. Thus, we aimed to characterize the chemical composition and the antitumoural and antiangiogenic activities of a sample from Pereiro (Portugal). The chemical profile of our propolis sample (P10.EE) is similar to the poplar propolis type. P10.EE decreased cell viability of different tumour cells, being less cytotoxic against non-tumoural cells. P10.EE decreased MDA-MB-231 and DU145 cell proliferation and migration, with cell cycle changes and increased cell death. The increased glucose consumption and lactate production in MDA-MB-231 cells is explained by an increased expression of different metabolism-related proteins. P10.EE induced a decrease in HBMEC cells total biomass and proliferation and decreased vessel sprouting in the chicken chorioallantoic membrane. Additionally, P10.EE potentiates paclitaxel effect in MDA-MB-231 and DU145 cells. Concluding, P10.EE can be a good candidate for cancer drug development since it affects different characteristics that dictate tumorigenesis.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/31677
url http://hdl.handle.net/1822/31677
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1756-4646
10.1016/j.jff.2014.09.009
http://www.journals.elsevier.com/journal-of-functional-foods/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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