Accumulation of organophosphorus pollutants in adipose tissue of obese women - metabolic alterations

Detalhes bibliográficos
Autor(a) principal: Sousa, Sara
Data de Publicação: 2023
Outros Autores: Rede, Diana, Cruz Fernandes, Virgínia, Pestana, Diogo, Faria, Gil, Delerue-Matos, Cristina, Calhau, Conceição, Fernandes Domingues, Valentina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/160873
Resumo: Funding Information: S. Sousa is grateful to FCT and ESF (European Social Fund) through POCH ( Programa Operacional Capital Humano ) for the Ph.D. grant ( SFRH/BD/137516/2018 and COVID/BD/153231/2023 ). The authors thank the General Surgery Department of Hospital de São João (Porto, Portugal) for the human adipose tissue samples and to all patients that consent to participate. Funding Information: This work was financially supported by Portuguese national funds through projects UIDB/50006/2020, UIDP/50006/2020 , and LA/P/0008/2020 , from the Fundação para a Ciência e a Tecnologia ( FCT )/Ministério da Ciência, Tecnologia e Ensino Superior ( MCTES ). Funding Information: S. Sousa is grateful to Fundação para a Ciência e a Tecnologia and European Social Fund through Programa Operacional Capital Humano for the Ph.D. grant ( SFRH/BD/137516/2018-COVID/BD/153231/2023 ). Publisher Copyright: © 2023 Elsevier Inc.
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spelling Accumulation of organophosphorus pollutants in adipose tissue of obese women - metabolic alterationsEndocrine disruptorsMetabolismObesityOrganophosphate estersOrganophosphorus pesticidesWomenBiochemistryEnvironmental Science(all)SDG 3 - Good Health and Well-beingFunding Information: S. Sousa is grateful to FCT and ESF (European Social Fund) through POCH ( Programa Operacional Capital Humano ) for the Ph.D. grant ( SFRH/BD/137516/2018 and COVID/BD/153231/2023 ). The authors thank the General Surgery Department of Hospital de São João (Porto, Portugal) for the human adipose tissue samples and to all patients that consent to participate. Funding Information: This work was financially supported by Portuguese national funds through projects UIDB/50006/2020, UIDP/50006/2020 , and LA/P/0008/2020 , from the Fundação para a Ciência e a Tecnologia ( FCT )/Ministério da Ciência, Tecnologia e Ensino Superior ( MCTES ). Funding Information: S. Sousa is grateful to Fundação para a Ciência e a Tecnologia and European Social Fund through Programa Operacional Capital Humano for the Ph.D. grant ( SFRH/BD/137516/2018-COVID/BD/153231/2023 ). Publisher Copyright: © 2023 Elsevier Inc.Organophosphorus pesticides (OPPs) and organophosphate esters (OPEs) are organophosphorus compounds created as substitutes for persistent environmental pollutants, namely organochlorines pesticides and brominated flame retardants, respectively. However, there is evidence that organophosphorus compounds are also widespread across the environment and have adverse effects on biota. In humans, OPPs and OPEs were reported to be carcinogenic, neurotoxic, hepatotoxic, nephrotoxic, amongst others. As lipophilic compounds, these accumulate in fat tissues as adipose tissue. Yet biomonitoring studies and analytical methodologies to assess these compounds in the human body are scarce, particularly in adipose tissue. In this study, the presence of six OPPs and seven OPEs was determined in samples of subcutaneous adipose tissue (scAT) and visceral adipose tissue (vAT) from 188 adult obese women. OPPs and OPEs were quantified by gas chromatography (GC) flame photometric detection and confirmed in GC tandem mass spectrometry. The detection frequencies ranged between 0.5-1.6% and 48–53%, respectively for OPPs and OPEs. Organophosphorus pollutants were present in both adipose tissues and median concentrations were 0.008 ± 0.020 μg/g scAT and 0.009 ± 0.020 μg/g vAT. A total of 32 Spearman's correlations were found between organophosphorus pollutants concentrations in adipose tissue and several biochemical parameters (18 positive and 14 negative). Our results show that anthropometric and hormonal parameters, cholesterol, glycaemia, macrominerals, urea and sedimentation velocity might be influenced by the presence of these compounds. The presence of organophosphorus pollutants in the environmental and their possible effect on female metabolic processes is concerning. Particularly because presently OPEs usage is not controlled or limited by any regulation. More studies are needed to fully understand these pollutants behaviour and hazard effects on human health, biota, and the environment so control regulations can be drawn to prevent and lessen their effects.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS)RUNSousa, SaraRede, DianaCruz Fernandes, VirgíniaPestana, DiogoFaria, GilDelerue-Matos, CristinaCalhau, ConceiçãoFernandes Domingues, Valentina2023-12-04T22:34:42Z2023-12-152023-12-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/160873eng0013-9351PURE: 77662917https://doi.org/10.1016/j.envres.2023.117337info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:43:38Zoai:run.unl.pt:10362/160873Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:58:15.135723Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Accumulation of organophosphorus pollutants in adipose tissue of obese women - metabolic alterations
title Accumulation of organophosphorus pollutants in adipose tissue of obese women - metabolic alterations
spellingShingle Accumulation of organophosphorus pollutants in adipose tissue of obese women - metabolic alterations
Sousa, Sara
Endocrine disruptors
Metabolism
Obesity
Organophosphate esters
Organophosphorus pesticides
Women
Biochemistry
Environmental Science(all)
SDG 3 - Good Health and Well-being
title_short Accumulation of organophosphorus pollutants in adipose tissue of obese women - metabolic alterations
title_full Accumulation of organophosphorus pollutants in adipose tissue of obese women - metabolic alterations
title_fullStr Accumulation of organophosphorus pollutants in adipose tissue of obese women - metabolic alterations
title_full_unstemmed Accumulation of organophosphorus pollutants in adipose tissue of obese women - metabolic alterations
title_sort Accumulation of organophosphorus pollutants in adipose tissue of obese women - metabolic alterations
author Sousa, Sara
author_facet Sousa, Sara
Rede, Diana
Cruz Fernandes, Virgínia
Pestana, Diogo
Faria, Gil
Delerue-Matos, Cristina
Calhau, Conceição
Fernandes Domingues, Valentina
author_role author
author2 Rede, Diana
Cruz Fernandes, Virgínia
Pestana, Diogo
Faria, Gil
Delerue-Matos, Cristina
Calhau, Conceição
Fernandes Domingues, Valentina
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS)
RUN
dc.contributor.author.fl_str_mv Sousa, Sara
Rede, Diana
Cruz Fernandes, Virgínia
Pestana, Diogo
Faria, Gil
Delerue-Matos, Cristina
Calhau, Conceição
Fernandes Domingues, Valentina
dc.subject.por.fl_str_mv Endocrine disruptors
Metabolism
Obesity
Organophosphate esters
Organophosphorus pesticides
Women
Biochemistry
Environmental Science(all)
SDG 3 - Good Health and Well-being
topic Endocrine disruptors
Metabolism
Obesity
Organophosphate esters
Organophosphorus pesticides
Women
Biochemistry
Environmental Science(all)
SDG 3 - Good Health and Well-being
description Funding Information: S. Sousa is grateful to FCT and ESF (European Social Fund) through POCH ( Programa Operacional Capital Humano ) for the Ph.D. grant ( SFRH/BD/137516/2018 and COVID/BD/153231/2023 ). The authors thank the General Surgery Department of Hospital de São João (Porto, Portugal) for the human adipose tissue samples and to all patients that consent to participate. Funding Information: This work was financially supported by Portuguese national funds through projects UIDB/50006/2020, UIDP/50006/2020 , and LA/P/0008/2020 , from the Fundação para a Ciência e a Tecnologia ( FCT )/Ministério da Ciência, Tecnologia e Ensino Superior ( MCTES ). Funding Information: S. Sousa is grateful to Fundação para a Ciência e a Tecnologia and European Social Fund through Programa Operacional Capital Humano for the Ph.D. grant ( SFRH/BD/137516/2018-COVID/BD/153231/2023 ). Publisher Copyright: © 2023 Elsevier Inc.
publishDate 2023
dc.date.none.fl_str_mv 2023-12-04T22:34:42Z
2023-12-15
2023-12-15T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/160873
url http://hdl.handle.net/10362/160873
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0013-9351
PURE: 77662917
https://doi.org/10.1016/j.envres.2023.117337
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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