Targeted siRNA Delivery Using Lipid Nanoparticles

Detalhes bibliográficos
Autor(a) principal: Jorge, Andreia
Data de Publicação: 2020
Outros Autores: Pais, Alberto, Vitorino, Carla
Tipo de documento: Livro
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/91066
https://doi.org/10.1007/978-1-4939-9798-5_14
Resumo: Efficient intracellular delivery of small-interfering ribonucleic acid (siRNA) to the target organ or tissues in the body is assumed as the main hurdle for a widespread use of siRNAs in the clinics. Solid lipid-based nanoparticles (SLNs) and derivatives can potentially fit this purpose by enabling to overcome the extracellular and intracellular physiological barriers affecting the delivery. For that, rational formulations and rational process designs are needed. This chapter addresses a comprehensive description and critical appraisal of the main production methods of this particular type of lipid nanoparticles and the leading strategies to prompt a targeted delivery of siRNA.
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spelling Targeted siRNA Delivery Using Lipid NanoparticlesRNA interferenceSolid lipid-based nanoparticlesTargetingsiRNA deliveryTemperature-based methodsSolvent-based methodsEfficient intracellular delivery of small-interfering ribonucleic acid (siRNA) to the target organ or tissues in the body is assumed as the main hurdle for a widespread use of siRNAs in the clinics. Solid lipid-based nanoparticles (SLNs) and derivatives can potentially fit this purpose by enabling to overcome the extracellular and intracellular physiological barriers affecting the delivery. For that, rational formulations and rational process designs are needed. This chapter addresses a comprehensive description and critical appraisal of the main production methods of this particular type of lipid nanoparticles and the leading strategies to prompt a targeted delivery of siRNA.Springer Nature2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookhttp://hdl.handle.net/10316/91066http://hdl.handle.net/10316/91066https://doi.org/10.1007/978-1-4939-9798-5_14eng978-1-4939-9797-8https://link.springer.com/protocol/10.1007%2F978-1-4939-9798-5_14Jorge, AndreiaPais, AlbertoVitorino, Carlainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-25T06:00:45Zoai:estudogeral.uc.pt:10316/91066Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:11:02.108905Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Targeted siRNA Delivery Using Lipid Nanoparticles
title Targeted siRNA Delivery Using Lipid Nanoparticles
spellingShingle Targeted siRNA Delivery Using Lipid Nanoparticles
Jorge, Andreia
RNA interference
Solid lipid-based nanoparticles
Targeting
siRNA delivery
Temperature-based methods
Solvent-based methods
title_short Targeted siRNA Delivery Using Lipid Nanoparticles
title_full Targeted siRNA Delivery Using Lipid Nanoparticles
title_fullStr Targeted siRNA Delivery Using Lipid Nanoparticles
title_full_unstemmed Targeted siRNA Delivery Using Lipid Nanoparticles
title_sort Targeted siRNA Delivery Using Lipid Nanoparticles
author Jorge, Andreia
author_facet Jorge, Andreia
Pais, Alberto
Vitorino, Carla
author_role author
author2 Pais, Alberto
Vitorino, Carla
author2_role author
author
dc.contributor.author.fl_str_mv Jorge, Andreia
Pais, Alberto
Vitorino, Carla
dc.subject.por.fl_str_mv RNA interference
Solid lipid-based nanoparticles
Targeting
siRNA delivery
Temperature-based methods
Solvent-based methods
topic RNA interference
Solid lipid-based nanoparticles
Targeting
siRNA delivery
Temperature-based methods
Solvent-based methods
description Efficient intracellular delivery of small-interfering ribonucleic acid (siRNA) to the target organ or tissues in the body is assumed as the main hurdle for a widespread use of siRNAs in the clinics. Solid lipid-based nanoparticles (SLNs) and derivatives can potentially fit this purpose by enabling to overcome the extracellular and intracellular physiological barriers affecting the delivery. For that, rational formulations and rational process designs are needed. This chapter addresses a comprehensive description and critical appraisal of the main production methods of this particular type of lipid nanoparticles and the leading strategies to prompt a targeted delivery of siRNA.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/book
format book
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/91066
http://hdl.handle.net/10316/91066
https://doi.org/10.1007/978-1-4939-9798-5_14
url http://hdl.handle.net/10316/91066
https://doi.org/10.1007/978-1-4939-9798-5_14
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 978-1-4939-9797-8
https://link.springer.com/protocol/10.1007%2F978-1-4939-9798-5_14
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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