Brain structure across the lifespan : the influence of stress and mood

Detalhes bibliográficos
Autor(a) principal: Soares, José Miguel
Data de Publicação: 2014
Outros Autores: Marques, Paulo César Gonçalves, Magalhães, Ricardo José Silva, Santos, Nadine Correia, Sousa, Nuno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/32478
Resumo: Normal brain aging is an inevitable and heterogeneous process characterized by a selective pattern of structural changes. Such heterogeneity arises as a consequence of cumulative effects over the lifespan, including stress and mood effects, which drive different micro- and macro-structural alterations in the brain. Investigating these differences in healthy age-related changes is a major challenge for the comprehension of the cognitive status. Herein we addressed the impact of normal aging, stress, mood, and their interplay in the brain gray and white matter (WM) structure. We showed the critical impact of age in the WM volume and how stress and mood influence brain volumetry across the lifespan. Moreover, we found a more profound effect of the interaction of aging/stress/mood on structures located in the left hemisphere. These findings help to clarify some divergent results associated with the aging decline and to enlighten the association between abnormal volumetric alterations and several states that may lead to psychiatric disorders.
id RCAP_3b5c32d20c899963ffe5315d8ef2a0db
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/32478
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Brain structure across the lifespan : the influence of stress and moodAgingStressMoodVolumetryGray matterWhite matterScience & TechnologyNormal brain aging is an inevitable and heterogeneous process characterized by a selective pattern of structural changes. Such heterogeneity arises as a consequence of cumulative effects over the lifespan, including stress and mood effects, which drive different micro- and macro-structural alterations in the brain. Investigating these differences in healthy age-related changes is a major challenge for the comprehension of the cognitive status. Herein we addressed the impact of normal aging, stress, mood, and their interplay in the brain gray and white matter (WM) structure. We showed the critical impact of age in the WM volume and how stress and mood influence brain volumetry across the lifespan. Moreover, we found a more profound effect of the interaction of aging/stress/mood on structures located in the left hemisphere. These findings help to clarify some divergent results associated with the aging decline and to enlighten the association between abnormal volumetric alterations and several states that may lead to psychiatric disorders.We are thankful to all study participants. This work was funded by the European Commission (FP7): "SwitchBox" (Contract HEALTH-F2-2010-259772) and co-financed by the Portuguese North Regional Operational Program (ON.2 - O Novo Norte) under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER). Jose M. Soares, Paulo Marques, and Nadine C. Santos are supported by fellowships of the project "SwitchBox"; Ricardo Magalhaes is supported by a fellowship from the project FCTANR/NEU-OSD/0258/2012 funded by FCT/MEC (www.fct.pt) and by ON.2 - ONOVONORTE - North - Portugal Regional Operational Programme 2007/2013, of the National Strategic Reference Framework (NSRF) 2007/2013, through FEDER.Frontiers MediaUniversidade do MinhoSoares, José MiguelMarques, Paulo César GonçalvesMagalhães, Ricardo José SilvaSantos, Nadine CorreiaSousa, Nuno20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/32478eng1663-436510.3389/fnagi.2014.00330http://www.frontiersin.orginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:59:32Zoai:repositorium.sdum.uminho.pt:1822/32478Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:49:20.187543Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Brain structure across the lifespan : the influence of stress and mood
title Brain structure across the lifespan : the influence of stress and mood
spellingShingle Brain structure across the lifespan : the influence of stress and mood
Soares, José Miguel
Aging
Stress
Mood
Volumetry
Gray matter
White matter
Science & Technology
title_short Brain structure across the lifespan : the influence of stress and mood
title_full Brain structure across the lifespan : the influence of stress and mood
title_fullStr Brain structure across the lifespan : the influence of stress and mood
title_full_unstemmed Brain structure across the lifespan : the influence of stress and mood
title_sort Brain structure across the lifespan : the influence of stress and mood
author Soares, José Miguel
author_facet Soares, José Miguel
Marques, Paulo César Gonçalves
Magalhães, Ricardo José Silva
Santos, Nadine Correia
Sousa, Nuno
author_role author
author2 Marques, Paulo César Gonçalves
Magalhães, Ricardo José Silva
Santos, Nadine Correia
Sousa, Nuno
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Soares, José Miguel
Marques, Paulo César Gonçalves
Magalhães, Ricardo José Silva
Santos, Nadine Correia
Sousa, Nuno
dc.subject.por.fl_str_mv Aging
Stress
Mood
Volumetry
Gray matter
White matter
Science & Technology
topic Aging
Stress
Mood
Volumetry
Gray matter
White matter
Science & Technology
description Normal brain aging is an inevitable and heterogeneous process characterized by a selective pattern of structural changes. Such heterogeneity arises as a consequence of cumulative effects over the lifespan, including stress and mood effects, which drive different micro- and macro-structural alterations in the brain. Investigating these differences in healthy age-related changes is a major challenge for the comprehension of the cognitive status. Herein we addressed the impact of normal aging, stress, mood, and their interplay in the brain gray and white matter (WM) structure. We showed the critical impact of age in the WM volume and how stress and mood influence brain volumetry across the lifespan. Moreover, we found a more profound effect of the interaction of aging/stress/mood on structures located in the left hemisphere. These findings help to clarify some divergent results associated with the aging decline and to enlighten the association between abnormal volumetric alterations and several states that may lead to psychiatric disorders.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/32478
url http://hdl.handle.net/1822/32478
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1663-4365
10.3389/fnagi.2014.00330
http://www.frontiersin.org
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132257418477568

Registros relacionados