Monocyte and myeloid dendritic cell activation occurs throughout HIV type 2 infection, an attenuated form of HIV disease.

Detalhes bibliográficos
Autor(a) principal: Cavaleiro, R.
Data de Publicação: 2013
Outros Autores: Tendeiro, R., Foxall, R. B., Soares, R. S., Baptista, A. P., Gomes, P., Valadas, Emília, Victorino, R. M., Sousa, A. E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/18303
Resumo: © The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
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spelling Monocyte and myeloid dendritic cell activation occurs throughout HIV type 2 infection, an attenuated form of HIV disease.HIV-2AIDSMonocytesMyeloid dendritic cellsPD-L1Immune activation© The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.Monocytes and myeloid dendritic cells (mDCs) are important orchestrators of innate and human immunodeficiency virus (HIV)-specific immune responses and of the generalized inflammation that characterizes AIDS progression. To our knowledge, we are the first to investigate monocyte and mDC imbalances in HIV type 2 (HIV-2)-positive patients, who typically feature reduced viremia and slow disease progression despite the recognized ability of HIV-2 to establish viral reservoirs and overcome host restriction factors in myeloid cells. We found a heightened state of monocyte and mDC activation throughout HIV-2 infection (characterized by CD14(bright)CD16(+) expansion, as well as increased levels of soluble CD14, HLA-DR, and CD86), together with progressive mDC depletion. Importantly, HIV-2-positive patients also featured overexpression of the inhibitory molecule PD-L1 on monocytes and mDCs, which may act by limiting the production of proinflammatory molecules. These data, from patients with a naturally occurring form of attenuated HIV disease, challenge current paradigms regarding the role of monocytes in HIV/AIDS and open new perspectives regarding potential strategies to modulate inflammatory states.This work was supported by the Fundação para a Ciência e a Tecnologia (scholarships to R. C., R. T., R. B. F. and R. S. S.), the Programa Operacional Ciência e Inovação 2010, and the Fundação Calouste Gulbenkian (to A. E. S.).Repositório da Universidade de LisboaCavaleiro, R.Tendeiro, R.Foxall, R. B.Soares, R. S.Baptista, A. P.Gomes, P.Valadas, EmíliaVictorino, R. M.Sousa, A. E.2015-06-17T13:42:26Z20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/18303engJID 2013:207 (1 June)0022-1899http://jid.oxfordjournals.org/content/207/11/1730.longmetadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:04:31Zoai:repositorio.ul.pt:10451/18303Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:37:53.733412Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Monocyte and myeloid dendritic cell activation occurs throughout HIV type 2 infection, an attenuated form of HIV disease.
title Monocyte and myeloid dendritic cell activation occurs throughout HIV type 2 infection, an attenuated form of HIV disease.
spellingShingle Monocyte and myeloid dendritic cell activation occurs throughout HIV type 2 infection, an attenuated form of HIV disease.
Cavaleiro, R.
HIV-2
AIDS
Monocytes
Myeloid dendritic cells
PD-L1
Immune activation
title_short Monocyte and myeloid dendritic cell activation occurs throughout HIV type 2 infection, an attenuated form of HIV disease.
title_full Monocyte and myeloid dendritic cell activation occurs throughout HIV type 2 infection, an attenuated form of HIV disease.
title_fullStr Monocyte and myeloid dendritic cell activation occurs throughout HIV type 2 infection, an attenuated form of HIV disease.
title_full_unstemmed Monocyte and myeloid dendritic cell activation occurs throughout HIV type 2 infection, an attenuated form of HIV disease.
title_sort Monocyte and myeloid dendritic cell activation occurs throughout HIV type 2 infection, an attenuated form of HIV disease.
author Cavaleiro, R.
author_facet Cavaleiro, R.
Tendeiro, R.
Foxall, R. B.
Soares, R. S.
Baptista, A. P.
Gomes, P.
Valadas, Emília
Victorino, R. M.
Sousa, A. E.
author_role author
author2 Tendeiro, R.
Foxall, R. B.
Soares, R. S.
Baptista, A. P.
Gomes, P.
Valadas, Emília
Victorino, R. M.
Sousa, A. E.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Cavaleiro, R.
Tendeiro, R.
Foxall, R. B.
Soares, R. S.
Baptista, A. P.
Gomes, P.
Valadas, Emília
Victorino, R. M.
Sousa, A. E.
dc.subject.por.fl_str_mv HIV-2
AIDS
Monocytes
Myeloid dendritic cells
PD-L1
Immune activation
topic HIV-2
AIDS
Monocytes
Myeloid dendritic cells
PD-L1
Immune activation
description © The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01T00:00:00Z
2015-06-17T13:42:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/18303
url http://hdl.handle.net/10451/18303
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv JID 2013:207 (1 June)
0022-1899
http://jid.oxfordjournals.org/content/207/11/1730.long
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instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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