Numerical-experimental analysis of the permeability-porosity relationship in triply periodic minimal surfaces scaffolds
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.8/8252 |
Resumo: | Bone Tissue Engineering has been focusing on improving the current methods for bone repair, being the use of scaffolds presented as an upgrade to traditional surgery techniques. Scaffolds are artificially porous matrices, meant to promote cell seeding and proliferation, being these properties influenced by the permeability of the structure. This work employed experimental pressure drop tests and Computational Fluid Dynamics models to assess permeability (and fluid streamlines) within different triply periodic minimal surfaces scaffold geometries (Schwarz D, Gyroid and Schwarz P). The pressure outputs from the computational analysis presented a good correlation with the experimental results, with R2 equal to 0.903; they have also shown that a lower porosity may not mean a lower permeability if the geometry is altered, such as the difference between 60% porous Gyroid scaffolds (8.1*10-9 mm2) and 70% porous Schwarz D scaffolds (7.1*10-9 mm2). Fluid streamlines revealed how the Gyroid geometries are the most appropriate design for most bone tissue engineering applications, due to their consistent fluid permeation, followed by Schwarz D. The Schwarz P geometries have shown flat streamlines and significant variation of the permeability with the porosity (an increase of 10% in their porosity lead to an increase in the permeability from 5.1*10-9 mm2 to 11.7*10-9 mm2), which would imply a poor environment for cell seeding and proliferation. |
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Numerical-experimental analysis of the permeability-porosity relationship in triply periodic minimal surfaces scaffoldsComputational fluid dynamicsTriply periodic minimal surfacesPermeabilityScaffoldsBone tissue engineeringBone Tissue Engineering has been focusing on improving the current methods for bone repair, being the use of scaffolds presented as an upgrade to traditional surgery techniques. Scaffolds are artificially porous matrices, meant to promote cell seeding and proliferation, being these properties influenced by the permeability of the structure. This work employed experimental pressure drop tests and Computational Fluid Dynamics models to assess permeability (and fluid streamlines) within different triply periodic minimal surfaces scaffold geometries (Schwarz D, Gyroid and Schwarz P). The pressure outputs from the computational analysis presented a good correlation with the experimental results, with R2 equal to 0.903; they have also shown that a lower porosity may not mean a lower permeability if the geometry is altered, such as the difference between 60% porous Gyroid scaffolds (8.1*10-9 mm2) and 70% porous Schwarz D scaffolds (7.1*10-9 mm2). Fluid streamlines revealed how the Gyroid geometries are the most appropriate design for most bone tissue engineering applications, due to their consistent fluid permeation, followed by Schwarz D. The Schwarz P geometries have shown flat streamlines and significant variation of the permeability with the porosity (an increase of 10% in their porosity lead to an increase in the permeability from 5.1*10-9 mm2 to 11.7*10-9 mm2), which would imply a poor environment for cell seeding and proliferation.ElsevierIC-OnlinePires, T.Santos, J.Ruben, R. B.Gouveia, B.Castro, A. P. G.Fernandes, P. R.2023-03-17T18:43:32Z2021-03-052021-03-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/8252engTiago Pires, Jorge Santos, Rui B. Ruben, Bárbara P. Gouveia, André P.G. Castro, Paulo R. Fernandes, Numerical-experimental analysis of the permeability-porosity relationship in triply periodic minimal surfaces scaffolds, Journal of Biomechanics, Volume 117, 2021, 110263, ISSN 0021-9290, https://doi.org/10.1016/j.jbiomech.2021.11026310.1016/j.jbiomech.2021.110263info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:56:56Zoai:iconline.ipleiria.pt:10400.8/8252Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:51:01.196245Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Numerical-experimental analysis of the permeability-porosity relationship in triply periodic minimal surfaces scaffolds |
title |
Numerical-experimental analysis of the permeability-porosity relationship in triply periodic minimal surfaces scaffolds |
spellingShingle |
Numerical-experimental analysis of the permeability-porosity relationship in triply periodic minimal surfaces scaffolds Pires, T. Computational fluid dynamics Triply periodic minimal surfaces Permeability Scaffolds Bone tissue engineering |
title_short |
Numerical-experimental analysis of the permeability-porosity relationship in triply periodic minimal surfaces scaffolds |
title_full |
Numerical-experimental analysis of the permeability-porosity relationship in triply periodic minimal surfaces scaffolds |
title_fullStr |
Numerical-experimental analysis of the permeability-porosity relationship in triply periodic minimal surfaces scaffolds |
title_full_unstemmed |
Numerical-experimental analysis of the permeability-porosity relationship in triply periodic minimal surfaces scaffolds |
title_sort |
Numerical-experimental analysis of the permeability-porosity relationship in triply periodic minimal surfaces scaffolds |
author |
Pires, T. |
author_facet |
Pires, T. Santos, J. Ruben, R. B. Gouveia, B. Castro, A. P. G. Fernandes, P. R. |
author_role |
author |
author2 |
Santos, J. Ruben, R. B. Gouveia, B. Castro, A. P. G. Fernandes, P. R. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
IC-Online |
dc.contributor.author.fl_str_mv |
Pires, T. Santos, J. Ruben, R. B. Gouveia, B. Castro, A. P. G. Fernandes, P. R. |
dc.subject.por.fl_str_mv |
Computational fluid dynamics Triply periodic minimal surfaces Permeability Scaffolds Bone tissue engineering |
topic |
Computational fluid dynamics Triply periodic minimal surfaces Permeability Scaffolds Bone tissue engineering |
description |
Bone Tissue Engineering has been focusing on improving the current methods for bone repair, being the use of scaffolds presented as an upgrade to traditional surgery techniques. Scaffolds are artificially porous matrices, meant to promote cell seeding and proliferation, being these properties influenced by the permeability of the structure. This work employed experimental pressure drop tests and Computational Fluid Dynamics models to assess permeability (and fluid streamlines) within different triply periodic minimal surfaces scaffold geometries (Schwarz D, Gyroid and Schwarz P). The pressure outputs from the computational analysis presented a good correlation with the experimental results, with R2 equal to 0.903; they have also shown that a lower porosity may not mean a lower permeability if the geometry is altered, such as the difference between 60% porous Gyroid scaffolds (8.1*10-9 mm2) and 70% porous Schwarz D scaffolds (7.1*10-9 mm2). Fluid streamlines revealed how the Gyroid geometries are the most appropriate design for most bone tissue engineering applications, due to their consistent fluid permeation, followed by Schwarz D. The Schwarz P geometries have shown flat streamlines and significant variation of the permeability with the porosity (an increase of 10% in their porosity lead to an increase in the permeability from 5.1*10-9 mm2 to 11.7*10-9 mm2), which would imply a poor environment for cell seeding and proliferation. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-03-05 2021-03-05T00:00:00Z 2023-03-17T18:43:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.8/8252 |
url |
http://hdl.handle.net/10400.8/8252 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Tiago Pires, Jorge Santos, Rui B. Ruben, Bárbara P. Gouveia, André P.G. Castro, Paulo R. Fernandes, Numerical-experimental analysis of the permeability-porosity relationship in triply periodic minimal surfaces scaffolds, Journal of Biomechanics, Volume 117, 2021, 110263, ISSN 0021-9290, https://doi.org/10.1016/j.jbiomech.2021.110263 10.1016/j.jbiomech.2021.110263 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137002210197504 |