Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/59009 |
Resumo: | Therapeutic liquid mixtures, as deep eutectic systems, are considered a sustainable strategy that can be useful for the modification and enhancement of the pharmacokinetics and pharmacodynamics of different active ingredients. In this study, we assessed the stability and antibacterial activity of therapeutic liquid formulations prepared with anti-tuberculosis drugs. Tuberculosis therapy presents various pitfalls related, for example, to the administration of prolonged regimens of multiple drugs, different severe adverse effects, low compliance of the patient to treatment and the development of drug resistance. During this study, it was possible to assess the physicochemical stability of the formulations for 6 months, by polarized optical microscopy, 1H NMR and FTIR-ATR. Furthermore, the mixtures present an antibacterial effect against a drug-susceptible Mycobacterium tuberculosis strain (H37Rv). This was particularly evident for the mixtures with ethambutol incorporated, making them interesting to pursue with further studies and evaluation of clinical applicability. Upon infection, it was also observed that a single and higher dose appears to be more effective than lower separate doses, which could allow the production of patient-friendly formulations. |
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Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapyAnti-tuberculosis drugsEutectic mixturesTherapeutic liquid mixturesTuberculosisTherapeutic liquid mixtures, as deep eutectic systems, are considered a sustainable strategy that can be useful for the modification and enhancement of the pharmacokinetics and pharmacodynamics of different active ingredients. In this study, we assessed the stability and antibacterial activity of therapeutic liquid formulations prepared with anti-tuberculosis drugs. Tuberculosis therapy presents various pitfalls related, for example, to the administration of prolonged regimens of multiple drugs, different severe adverse effects, low compliance of the patient to treatment and the development of drug resistance. During this study, it was possible to assess the physicochemical stability of the formulations for 6 months, by polarized optical microscopy, 1H NMR and FTIR-ATR. Furthermore, the mixtures present an antibacterial effect against a drug-susceptible Mycobacterium tuberculosis strain (H37Rv). This was particularly evident for the mixtures with ethambutol incorporated, making them interesting to pursue with further studies and evaluation of clinical applicability. Upon infection, it was also observed that a single and higher dose appears to be more effective than lower separate doses, which could allow the production of patient-friendly formulations.This project has received funding from the European Union’s Horizon 2020 (European Research Council) under grant agreement No ERC-2016-CoG 725034 and was supported by the Associate Laboratory for Green Chemistry-LAQV which is financed by national funds from FCT/MCTES (UIDB/50006/2020) and from grants from the National Foundation for Science, FCT Fundação para a Ciência e Tecnologia – Portugal, PTDC/SAU-INF/28182/2017 to EA, UID/DTP/04138/2019 (to IMed-UL Lisboa). We also thank the support of ADEIM-FFUL (Associação para o Ensino e a Investigação em Microbiologia).ElsevierRepositório da Universidade de LisboaSantos, FilipaPires, DavidAnes, ElsaDuarte, Ana Rita C.2023-08-24T16:23:04Z2023-032023-06-02T16:31:52Z2023-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/59009engSantos F, Pires D, Anes E, Duarte ARC. Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy. International Journal of Pharmaceutics [Internet]. 25 de abril de 2023;637:122862. Disponível em: https://www.sciencedirect.com/science/article/pii/S037851732300282X0378-5173cv-prod-319554810.1016/j.ijpharm.2023.122862info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:06:41Zoai:repositorio.ul.pt:10451/59009Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:08:20.312757Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy |
title |
Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy |
spellingShingle |
Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy Santos, Filipa Anti-tuberculosis drugs Eutectic mixtures Therapeutic liquid mixtures Tuberculosis |
title_short |
Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy |
title_full |
Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy |
title_fullStr |
Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy |
title_full_unstemmed |
Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy |
title_sort |
Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy |
author |
Santos, Filipa |
author_facet |
Santos, Filipa Pires, David Anes, Elsa Duarte, Ana Rita C. |
author_role |
author |
author2 |
Pires, David Anes, Elsa Duarte, Ana Rita C. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Santos, Filipa Pires, David Anes, Elsa Duarte, Ana Rita C. |
dc.subject.por.fl_str_mv |
Anti-tuberculosis drugs Eutectic mixtures Therapeutic liquid mixtures Tuberculosis |
topic |
Anti-tuberculosis drugs Eutectic mixtures Therapeutic liquid mixtures Tuberculosis |
description |
Therapeutic liquid mixtures, as deep eutectic systems, are considered a sustainable strategy that can be useful for the modification and enhancement of the pharmacokinetics and pharmacodynamics of different active ingredients. In this study, we assessed the stability and antibacterial activity of therapeutic liquid formulations prepared with anti-tuberculosis drugs. Tuberculosis therapy presents various pitfalls related, for example, to the administration of prolonged regimens of multiple drugs, different severe adverse effects, low compliance of the patient to treatment and the development of drug resistance. During this study, it was possible to assess the physicochemical stability of the formulations for 6 months, by polarized optical microscopy, 1H NMR and FTIR-ATR. Furthermore, the mixtures present an antibacterial effect against a drug-susceptible Mycobacterium tuberculosis strain (H37Rv). This was particularly evident for the mixtures with ethambutol incorporated, making them interesting to pursue with further studies and evaluation of clinical applicability. Upon infection, it was also observed that a single and higher dose appears to be more effective than lower separate doses, which could allow the production of patient-friendly formulations. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-08-24T16:23:04Z 2023-03 2023-06-02T16:31:52Z 2023-03-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/59009 |
url |
http://hdl.handle.net/10451/59009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Santos F, Pires D, Anes E, Duarte ARC. Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy. International Journal of Pharmaceutics [Internet]. 25 de abril de 2023;637:122862. Disponível em: https://www.sciencedirect.com/science/article/pii/S037851732300282X 0378-5173 cv-prod-3195548 10.1016/j.ijpharm.2023.122862 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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