TNF inhibitors reduce spinal radiographic progression in patients with radiographic axial spondyloarthritis

Detalhes bibliográficos
Autor(a) principal: Sepriano, Alexandre
Data de Publicação: 2021
Outros Autores: Ramiro, Sofia, Wichuk, Stephanie, Chiowchanwisawakit, Praveena, Paschke, Joel, van der Heijde, Désirée, Landewé, Robert, Maksymowych, Walter P
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/135560
Resumo: This article is protected by copyright. All rights reserved.
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spelling TNF inhibitors reduce spinal radiographic progression in patients with radiographic axial spondyloarthritisa longitudinal analysis from the ALBERTA FORCAST cohortThis article is protected by copyright. All rights reserved.AIM: To investigate whether TNF inhibitors (TNFi) impact spinal radiographic progression in patients with axial spondyloarthritis (axSpA) and whether this is coupled to their effect on inflammation. METHODS: Patients with axSpA fulfilling the modified New York criteria were included in this prospective cohort (ALBERTA FORCAST). Spine radiographs, done every 2 years up to 10 years, were scored by 2 central readers, using the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS). The indirect effect of TNFi on mSASSS was evaluated with generalized estimating equations by testing the interaction between TNFi and ASDAS at the start of each 2-year interval (t). If significant, the association between ASDAS at t and mSASSS at the end of the interval (t+1) was assessed in: i. patients treated with TNFi in all visits; ii. some visits and iii. never treated. In addition, the association between TNFi at t and mSASSS at t+1 (adjusting for ASDAS at t) was also tested (direct effect). RESULTS: In total, 314 patients were included. A gradient was seen for the effect of ASDAS at t on mSASSS at t+1 (interaction p-value 0.10), with a higher progression in patients never treated with TNFi [β (95% CI): 0.41 (0.13; 0.68)] compared to those continuously treated [0.16 (0.00;0.31)] (indirect effect). However, TNFi also directly slowed progression as treated patients had on average 0.85 mSASSS-units less on t+1 compared to those not treated [-0.85 (-1.35; -0.35)]. CONCLUSION: TNFi reduce spinal radiographic progression in patients with radiographic axSpA which might be partially uncoupled from their effects on ASDAS inflammation.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNSepriano, AlexandreRamiro, SofiaWichuk, StephanieChiowchanwisawakit, PraveenaPaschke, Joelvan der Heijde, DésiréeLandewé, RobertMaksymowych, Walter P2022-03-30T23:02:50Z2021-072021-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/135560eng2326-5191PURE: 28267527https://doi.org/10.1002/art.41667info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:13:56Zoai:run.unl.pt:10362/135560Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:48:27.309131Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv TNF inhibitors reduce spinal radiographic progression in patients with radiographic axial spondyloarthritis
a longitudinal analysis from the ALBERTA FORCAST cohort
title TNF inhibitors reduce spinal radiographic progression in patients with radiographic axial spondyloarthritis
spellingShingle TNF inhibitors reduce spinal radiographic progression in patients with radiographic axial spondyloarthritis
Sepriano, Alexandre
title_short TNF inhibitors reduce spinal radiographic progression in patients with radiographic axial spondyloarthritis
title_full TNF inhibitors reduce spinal radiographic progression in patients with radiographic axial spondyloarthritis
title_fullStr TNF inhibitors reduce spinal radiographic progression in patients with radiographic axial spondyloarthritis
title_full_unstemmed TNF inhibitors reduce spinal radiographic progression in patients with radiographic axial spondyloarthritis
title_sort TNF inhibitors reduce spinal radiographic progression in patients with radiographic axial spondyloarthritis
author Sepriano, Alexandre
author_facet Sepriano, Alexandre
Ramiro, Sofia
Wichuk, Stephanie
Chiowchanwisawakit, Praveena
Paschke, Joel
van der Heijde, Désirée
Landewé, Robert
Maksymowych, Walter P
author_role author
author2 Ramiro, Sofia
Wichuk, Stephanie
Chiowchanwisawakit, Praveena
Paschke, Joel
van der Heijde, Désirée
Landewé, Robert
Maksymowych, Walter P
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Sepriano, Alexandre
Ramiro, Sofia
Wichuk, Stephanie
Chiowchanwisawakit, Praveena
Paschke, Joel
van der Heijde, Désirée
Landewé, Robert
Maksymowych, Walter P
description This article is protected by copyright. All rights reserved.
publishDate 2021
dc.date.none.fl_str_mv 2021-07
2021-07-01T00:00:00Z
2022-03-30T23:02:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/135560
url http://hdl.handle.net/10362/135560
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2326-5191
PURE: 28267527
https://doi.org/10.1002/art.41667
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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