Fast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studies

Detalhes bibliográficos
Autor(a) principal: Vojtek, Martin
Data de Publicação: 2020
Outros Autores: Pinto, Edgar, Gonçalves-Monteiro, Salomé, Almeida, Agostinho, Marques, M. P. M., Mota-File, Hélder, Ferreira, Isabel M. P. L. V. O., Diniz, Carmen
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/16535
Resumo: Palladium-(Pd)-based drugs are emerging as alternatives to platinum (Pt) anticancer chemotherapeutics, which increases the need for efficient and suitable procedures of Pd analysis in reduced amounts of pre-clinical animal samples. Herein, an ICP-MS (inductively coupled plasma-mass spectrometry) method was developed and validated for simple and fast analysis of Pd/Pt-based drugs in 11 distinct biological matrices (adipose tissue, muscle, liver, kidney, spleen, testis, heart, lungs, brain, blood and serum).
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spelling Fast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studiesICP-MSPharmacokineticAnimalPalladiumPalladium-(Pd)-based drugs are emerging as alternatives to platinum (Pt) anticancer chemotherapeutics, which increases the need for efficient and suitable procedures of Pd analysis in reduced amounts of pre-clinical animal samples. Herein, an ICP-MS (inductively coupled plasma-mass spectrometry) method was developed and validated for simple and fast analysis of Pd/Pt-based drugs in 11 distinct biological matrices (adipose tissue, muscle, liver, kidney, spleen, testis, heart, lungs, brain, blood and serum).Royal Society of ChemistryRepositório Científico do Instituto Politécnico do PortoVojtek, MartinPinto, EdgarGonçalves-Monteiro, SaloméAlmeida, AgostinhoMarques, M. P. M.Mota-File, HélderFerreira, Isabel M. P. L. V. O.Diniz, Carmen2021-08-21T00:30:30Z2020-08-212020-08-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/16535engVojtek, M., Pinto, E., Gonçalves-Monteiro, S., Almeida, A., Marques, M. P. M., Mota-Filipe, H., Ferreira, I. M. P. L. V. O., & Diniz, C. (2020). Fast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studies [10.1039/D0AY01328E]. Analytical Methods, 12(39), 4806-4812. https://doi.org/10.1039/D0AY01328E10.1039/D0AY01328Einfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T13:03:41Zoai:recipp.ipp.pt:10400.22/16535Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:36:11.534259Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Fast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studies
title Fast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studies
spellingShingle Fast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studies
Vojtek, Martin
ICP-MS
Pharmacokinetic
Animal
Palladium
title_short Fast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studies
title_full Fast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studies
title_fullStr Fast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studies
title_full_unstemmed Fast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studies
title_sort Fast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studies
author Vojtek, Martin
author_facet Vojtek, Martin
Pinto, Edgar
Gonçalves-Monteiro, Salomé
Almeida, Agostinho
Marques, M. P. M.
Mota-File, Hélder
Ferreira, Isabel M. P. L. V. O.
Diniz, Carmen
author_role author
author2 Pinto, Edgar
Gonçalves-Monteiro, Salomé
Almeida, Agostinho
Marques, M. P. M.
Mota-File, Hélder
Ferreira, Isabel M. P. L. V. O.
Diniz, Carmen
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Vojtek, Martin
Pinto, Edgar
Gonçalves-Monteiro, Salomé
Almeida, Agostinho
Marques, M. P. M.
Mota-File, Hélder
Ferreira, Isabel M. P. L. V. O.
Diniz, Carmen
dc.subject.por.fl_str_mv ICP-MS
Pharmacokinetic
Animal
Palladium
topic ICP-MS
Pharmacokinetic
Animal
Palladium
description Palladium-(Pd)-based drugs are emerging as alternatives to platinum (Pt) anticancer chemotherapeutics, which increases the need for efficient and suitable procedures of Pd analysis in reduced amounts of pre-clinical animal samples. Herein, an ICP-MS (inductively coupled plasma-mass spectrometry) method was developed and validated for simple and fast analysis of Pd/Pt-based drugs in 11 distinct biological matrices (adipose tissue, muscle, liver, kidney, spleen, testis, heart, lungs, brain, blood and serum).
publishDate 2020
dc.date.none.fl_str_mv 2020-08-21
2020-08-21T00:00:00Z
2021-08-21T00:30:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/16535
url http://hdl.handle.net/10400.22/16535
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Vojtek, M., Pinto, E., Gonçalves-Monteiro, S., Almeida, A., Marques, M. P. M., Mota-Filipe, H., Ferreira, I. M. P. L. V. O., & Diniz, C. (2020). Fast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studies [10.1039/D0AY01328E]. Analytical Methods, 12(39), 4806-4812. https://doi.org/10.1039/D0AY01328E
10.1039/D0AY01328E
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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