Hypoxia in vascular networks: a complex system approach to unravel the diabetic paradox
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/109649 https://doi.org/10.1371/journal.pone.0113165 |
Resumo: | In this work we model the extent of hypoxia in the diabetic retina as a function of the area affected by vessel disruption. We find two regimes that differ on the ratio between the area of disrupted vasculature and the area of tissue in hypoxia. In the first regime the hypoxia is localized in the vicinity of the vascular disruption, while in the second regime there is a generalized hypoxia in the affected tissue. The transition between these two regimes occurs when the tissue area affected by individual sites of vessel damage is on the order of the square of the characteristic irrigation length in the tissue (the maximum distance that an irrigated point in the tissue is from an existing vessel). We observe that very high levels of hypoxia are correlated with the rupture of larger vessels in the retina, and with smaller radii of individual sites of vessel damage. Based on this property of vascular networks, we propose a novel mechanism for the transition between the nonproliferative and the proliferative stages in diabetic retinopathy. |
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Hypoxia in vascular networks: a complex system approach to unravel the diabetic paradoxAlgorithmsCell HypoxiaDiabetic RetinopathyHumansRetinal VesselsVesicular Transport ProteinsIn this work we model the extent of hypoxia in the diabetic retina as a function of the area affected by vessel disruption. We find two regimes that differ on the ratio between the area of disrupted vasculature and the area of tissue in hypoxia. In the first regime the hypoxia is localized in the vicinity of the vascular disruption, while in the second regime there is a generalized hypoxia in the affected tissue. The transition between these two regimes occurs when the tissue area affected by individual sites of vessel damage is on the order of the square of the characteristic irrigation length in the tissue (the maximum distance that an irrigated point in the tissue is from an existing vessel). We observe that very high levels of hypoxia are correlated with the rupture of larger vessels in the retina, and with smaller radii of individual sites of vessel damage. Based on this property of vascular networks, we propose a novel mechanism for the transition between the nonproliferative and the proliferative stages in diabetic retinopathy.Public Library of Science2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/109649http://hdl.handle.net/10316/109649https://doi.org/10.1371/journal.pone.0113165eng1932-6203Gandica, Y.Schwarz, TobiasOliveira, OrlandoTravasso, Rui D.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-19T11:22:57Zoai:estudogeral.uc.pt:10316/109649Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:48.607653Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Hypoxia in vascular networks: a complex system approach to unravel the diabetic paradox |
title |
Hypoxia in vascular networks: a complex system approach to unravel the diabetic paradox |
spellingShingle |
Hypoxia in vascular networks: a complex system approach to unravel the diabetic paradox Gandica, Y. Algorithms Cell Hypoxia Diabetic Retinopathy Humans Retinal Vessels Vesicular Transport Proteins |
title_short |
Hypoxia in vascular networks: a complex system approach to unravel the diabetic paradox |
title_full |
Hypoxia in vascular networks: a complex system approach to unravel the diabetic paradox |
title_fullStr |
Hypoxia in vascular networks: a complex system approach to unravel the diabetic paradox |
title_full_unstemmed |
Hypoxia in vascular networks: a complex system approach to unravel the diabetic paradox |
title_sort |
Hypoxia in vascular networks: a complex system approach to unravel the diabetic paradox |
author |
Gandica, Y. |
author_facet |
Gandica, Y. Schwarz, Tobias Oliveira, Orlando Travasso, Rui D. |
author_role |
author |
author2 |
Schwarz, Tobias Oliveira, Orlando Travasso, Rui D. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Gandica, Y. Schwarz, Tobias Oliveira, Orlando Travasso, Rui D. |
dc.subject.por.fl_str_mv |
Algorithms Cell Hypoxia Diabetic Retinopathy Humans Retinal Vessels Vesicular Transport Proteins |
topic |
Algorithms Cell Hypoxia Diabetic Retinopathy Humans Retinal Vessels Vesicular Transport Proteins |
description |
In this work we model the extent of hypoxia in the diabetic retina as a function of the area affected by vessel disruption. We find two regimes that differ on the ratio between the area of disrupted vasculature and the area of tissue in hypoxia. In the first regime the hypoxia is localized in the vicinity of the vascular disruption, while in the second regime there is a generalized hypoxia in the affected tissue. The transition between these two regimes occurs when the tissue area affected by individual sites of vessel damage is on the order of the square of the characteristic irrigation length in the tissue (the maximum distance that an irrigated point in the tissue is from an existing vessel). We observe that very high levels of hypoxia are correlated with the rupture of larger vessels in the retina, and with smaller radii of individual sites of vessel damage. Based on this property of vascular networks, we propose a novel mechanism for the transition between the nonproliferative and the proliferative stages in diabetic retinopathy. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/109649 http://hdl.handle.net/10316/109649 https://doi.org/10.1371/journal.pone.0113165 |
url |
http://hdl.handle.net/10316/109649 https://doi.org/10.1371/journal.pone.0113165 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1932-6203 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Public Library of Science |
publisher.none.fl_str_mv |
Public Library of Science |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134140148219904 |