Positron emission tomography in ischemic heart disease
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/101606 https://doi.org/10.1016/j.repc.2019.02.011 |
Resumo: | Non-invasive assessment of ischemic heart disease remains a challenging task, even with a large armory of diagnostic modalities. Positron emission tomography (PET) is an advanced radionuclide technique that has been available for decades. Originally used as a research tool that contributed to advances in the understanding of cardiovascular pathophysiology, it is now becoming established in clinical practice and is increasingly used in the diagnosis and risk stratification of patients with ischemic heart disease. PET myocardial perfusion imaging has a mean sensitivity and specificity of around 90% for the detection of angiographically significant coronary artery disease, and is also highly accurate for assessing the prognosis of patients with ischemic heart disease. Depending on the radiotracer used, it can provide information not only on myocardial perfusion but also on myocardial metabolism, which is essential for viability assessment. The potential of this imaging technique has been further increased with the introduction of hybrid scanners, which combine PET with computed tomography or cardiac magnetic resonance imaging, offering integrated morphological and functional information and hence comprehensive assessment of the effects of atherosclerosis on the myocardium. The scope of this review is to summarize the role of PET in ischemic heart disease. |
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Positron emission tomography in ischemic heart diseaseTomografia de emissão de positrões na doença cardíaca isquémicaPositron emission tomography/ computed tomographyIschemic heart diseasePerfusion imaging;Myocardial viabilityPET-CTDoença cardíaca isquémicaPerfusão miocárdicaViabilidade miocárdicaHumansMyocardial IschemiaPositron-Emission TomographyReproducibility of ResultsNon-invasive assessment of ischemic heart disease remains a challenging task, even with a large armory of diagnostic modalities. Positron emission tomography (PET) is an advanced radionuclide technique that has been available for decades. Originally used as a research tool that contributed to advances in the understanding of cardiovascular pathophysiology, it is now becoming established in clinical practice and is increasingly used in the diagnosis and risk stratification of patients with ischemic heart disease. PET myocardial perfusion imaging has a mean sensitivity and specificity of around 90% for the detection of angiographically significant coronary artery disease, and is also highly accurate for assessing the prognosis of patients with ischemic heart disease. Depending on the radiotracer used, it can provide information not only on myocardial perfusion but also on myocardial metabolism, which is essential for viability assessment. The potential of this imaging technique has been further increased with the introduction of hybrid scanners, which combine PET with computed tomography or cardiac magnetic resonance imaging, offering integrated morphological and functional information and hence comprehensive assessment of the effects of atherosclerosis on the myocardium. The scope of this review is to summarize the role of PET in ischemic heart disease.A multiplicidade de técnicas de diagnóstico existentes, para avaliac¸ão da doenc¸a cardíaca isquémica, pode representar um desafio na escolha da mais adequada se não forem conhecidas as características de cada uma, nomeadamente, potencialidades, disponibilidade, riscos inerentes e custos. A tomografia de emissão de positrões (PET) é uma técnica de imagem com várias décadas de evoluc¸ão. Usada inicialmente no campo da investigac¸ão, contribuiu para avanc¸os significativos na compreensão da fisiopatolologia cardiovascular. Atualmente, tem um papel cada vez mais relevante no diagnóstico e estratificac¸ão de risco da doenc¸a cardíaca isquémica. A imagem de perfusão miocárdica por PET tem uma especificidade e sensibili-dade médias de 90% para a detec¸ão de doenc¸a coronária arterial significativa. Dependendo doradiofármaco escolhido, a informac¸ão poderá versar sobre a perfusão miocárdica mas tambémsobre o seu metabolismo, essencial, na apreciac¸ão da viabilidade. O potencial desta técnicade imagem aumentou com a introduc¸ão das câmaras híbridas que a combinam com a tomo-grafia computorizada ou com a ressonância magnética cardíaca. Estas integram informac¸ãomorfológica e funcional, fornecendo uma avaliac¸ão completa das consequências da ateroscle-rose no miocárdio. Com esta revisão pretendeu dar-se uma panorâmica da aplicac¸ão da PET noâmbito da doenc¸a cardíaca isquémica.2019-08info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/101606http://hdl.handle.net/10316/101606https://doi.org/10.1016/j.repc.2019.02.011eng08702551Santos, Beatriz SaldanhaFerreira, Maria Joãoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-02T20:48:27Zoai:estudogeral.uc.pt:10316/101606Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:18:45.781577Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Positron emission tomography in ischemic heart disease Tomografia de emissão de positrões na doença cardíaca isquémica |
title |
Positron emission tomography in ischemic heart disease |
spellingShingle |
Positron emission tomography in ischemic heart disease Santos, Beatriz Saldanha Positron emission tomography/ computed tomography Ischemic heart disease Perfusion imaging; Myocardial viability PET-CT Doença cardíaca isquémica Perfusão miocárdica Viabilidade miocárdica Humans Myocardial Ischemia Positron-Emission Tomography Reproducibility of Results |
title_short |
Positron emission tomography in ischemic heart disease |
title_full |
Positron emission tomography in ischemic heart disease |
title_fullStr |
Positron emission tomography in ischemic heart disease |
title_full_unstemmed |
Positron emission tomography in ischemic heart disease |
title_sort |
Positron emission tomography in ischemic heart disease |
author |
Santos, Beatriz Saldanha |
author_facet |
Santos, Beatriz Saldanha Ferreira, Maria João |
author_role |
author |
author2 |
Ferreira, Maria João |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Santos, Beatriz Saldanha Ferreira, Maria João |
dc.subject.por.fl_str_mv |
Positron emission tomography/ computed tomography Ischemic heart disease Perfusion imaging; Myocardial viability PET-CT Doença cardíaca isquémica Perfusão miocárdica Viabilidade miocárdica Humans Myocardial Ischemia Positron-Emission Tomography Reproducibility of Results |
topic |
Positron emission tomography/ computed tomography Ischemic heart disease Perfusion imaging; Myocardial viability PET-CT Doença cardíaca isquémica Perfusão miocárdica Viabilidade miocárdica Humans Myocardial Ischemia Positron-Emission Tomography Reproducibility of Results |
description |
Non-invasive assessment of ischemic heart disease remains a challenging task, even with a large armory of diagnostic modalities. Positron emission tomography (PET) is an advanced radionuclide technique that has been available for decades. Originally used as a research tool that contributed to advances in the understanding of cardiovascular pathophysiology, it is now becoming established in clinical practice and is increasingly used in the diagnosis and risk stratification of patients with ischemic heart disease. PET myocardial perfusion imaging has a mean sensitivity and specificity of around 90% for the detection of angiographically significant coronary artery disease, and is also highly accurate for assessing the prognosis of patients with ischemic heart disease. Depending on the radiotracer used, it can provide information not only on myocardial perfusion but also on myocardial metabolism, which is essential for viability assessment. The potential of this imaging technique has been further increased with the introduction of hybrid scanners, which combine PET with computed tomography or cardiac magnetic resonance imaging, offering integrated morphological and functional information and hence comprehensive assessment of the effects of atherosclerosis on the myocardium. The scope of this review is to summarize the role of PET in ischemic heart disease. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-08 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/101606 http://hdl.handle.net/10316/101606 https://doi.org/10.1016/j.repc.2019.02.011 |
url |
http://hdl.handle.net/10316/101606 https://doi.org/10.1016/j.repc.2019.02.011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
08702551 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134082251096064 |