Identification of octopaminergic neurons that modulate sleep suppression by male sex drive
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/62013 |
Resumo: | Molecular and circuit mechanisms for balancing competing drives are not well understood. While circadian and homeostatic mechanisms generally ensure sufficient sleep at night, other pressing needs can overcome sleep drive. Here, we demonstrate that the balance between sleep and sex drives determines whether male flies sleep or court, and identify a subset of octopaminergic neurons (MS1) that regulate sleep specifically in males. When MS1 neurons are activated, isolated males sleep less, and when MS1 neurons are silenced, the normal male sleep suppression in female presence is attenuated and mating behavior is impaired. MS1 neurons do not express the sexually dimorphic FRUITLESS (FRU) transcription factor, but form male-specific contacts with FRU-expressing neurons; calcium imaging experiments reveal bidirectional functional connectivity between MS1 and FRU neurons. We propose octopaminergic MS1 neurons interact with the FRU network to mediate sleep suppression by male sex drive. |
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Identification of octopaminergic neurons that modulate sleep suppression by male sex driveAnimalsDipteraMaleNeuronsOctopamineSexual Behavior, AnimalSleepScience & TechnologyMolecular and circuit mechanisms for balancing competing drives are not well understood. While circadian and homeostatic mechanisms generally ensure sufficient sleep at night, other pressing needs can overcome sleep drive. Here, we demonstrate that the balance between sleep and sex drives determines whether male flies sleep or court, and identify a subset of octopaminergic neurons (MS1) that regulate sleep specifically in males. When MS1 neurons are activated, isolated males sleep less, and when MS1 neurons are silenced, the normal male sleep suppression in female presence is attenuated and mating behavior is impaired. MS1 neurons do not express the sexually dimorphic FRUITLESS (FRU) transcription factor, but form male-specific contacts with FRU-expressing neurons; calcium imaging experiments reveal bidirectional functional connectivity between MS1 and FRU neurons. We propose octopaminergic MS1 neurons interact with the FRU network to mediate sleep suppression by male sex drive.National Institute of Neurological Disorders and Stroke R21NS094782 Kyunghee KohNational Institute of Neurological Disorders and Stroke R01NS086887 Kyunghee KohNational Heart, Lung, and Blood Institute T32HL07713 Emilia H MoscatoBurroughs Wellcome Fund Career Award for Medical Scientists Matthew KayserPortuguese Foundation for Science and Technology SFRH-BD-52321-2013 Daniel R MachadoPortuguese Foundation for Science and Technology SFRH-BD-51726-2011 Dinis JS AfonsoeLife Sciences PublicationsUniversidade do MinhoMachado, Daniel R.Afonso, Dinis J. S.Kenny, Alexandra R.Öztürk-Çolak, ArzuMoscato, Emilia H.Mainwaring, BenjaminKayser, MatthewKoh, Kyunghee20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/62013eng2050-084X2050-084X10.7554/eLife.2313028510528info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-23T01:28:35Zoai:repositorium.sdum.uminho.pt:1822/62013Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:57:04.471754Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Identification of octopaminergic neurons that modulate sleep suppression by male sex drive |
title |
Identification of octopaminergic neurons that modulate sleep suppression by male sex drive |
spellingShingle |
Identification of octopaminergic neurons that modulate sleep suppression by male sex drive Machado, Daniel R. Animals Diptera Male Neurons Octopamine Sexual Behavior, Animal Sleep Science & Technology |
title_short |
Identification of octopaminergic neurons that modulate sleep suppression by male sex drive |
title_full |
Identification of octopaminergic neurons that modulate sleep suppression by male sex drive |
title_fullStr |
Identification of octopaminergic neurons that modulate sleep suppression by male sex drive |
title_full_unstemmed |
Identification of octopaminergic neurons that modulate sleep suppression by male sex drive |
title_sort |
Identification of octopaminergic neurons that modulate sleep suppression by male sex drive |
author |
Machado, Daniel R. |
author_facet |
Machado, Daniel R. Afonso, Dinis J. S. Kenny, Alexandra R. Öztürk-Çolak, Arzu Moscato, Emilia H. Mainwaring, Benjamin Kayser, Matthew Koh, Kyunghee |
author_role |
author |
author2 |
Afonso, Dinis J. S. Kenny, Alexandra R. Öztürk-Çolak, Arzu Moscato, Emilia H. Mainwaring, Benjamin Kayser, Matthew Koh, Kyunghee |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Machado, Daniel R. Afonso, Dinis J. S. Kenny, Alexandra R. Öztürk-Çolak, Arzu Moscato, Emilia H. Mainwaring, Benjamin Kayser, Matthew Koh, Kyunghee |
dc.subject.por.fl_str_mv |
Animals Diptera Male Neurons Octopamine Sexual Behavior, Animal Sleep Science & Technology |
topic |
Animals Diptera Male Neurons Octopamine Sexual Behavior, Animal Sleep Science & Technology |
description |
Molecular and circuit mechanisms for balancing competing drives are not well understood. While circadian and homeostatic mechanisms generally ensure sufficient sleep at night, other pressing needs can overcome sleep drive. Here, we demonstrate that the balance between sleep and sex drives determines whether male flies sleep or court, and identify a subset of octopaminergic neurons (MS1) that regulate sleep specifically in males. When MS1 neurons are activated, isolated males sleep less, and when MS1 neurons are silenced, the normal male sleep suppression in female presence is attenuated and mating behavior is impaired. MS1 neurons do not express the sexually dimorphic FRUITLESS (FRU) transcription factor, but form male-specific contacts with FRU-expressing neurons; calcium imaging experiments reveal bidirectional functional connectivity between MS1 and FRU neurons. We propose octopaminergic MS1 neurons interact with the FRU network to mediate sleep suppression by male sex drive. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/62013 |
url |
https://hdl.handle.net/1822/62013 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2050-084X 2050-084X 10.7554/eLife.23130 28510528 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
eLife Sciences Publications |
publisher.none.fl_str_mv |
eLife Sciences Publications |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132358826262528 |