Labdanum resin from Cistus ladanifer L.: a natural and sustainable ingredient for skin care cosmetics with relevant cosmeceutical bioactivities
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.11/8154 |
Resumo: | Labdanum resin from Cistus ladanifer L. (Cistaceae) is an abundant natural resource in the Iberian Peninsula worth being explored in a sustainable manner. It is already used in the cosmetic industry; mainly by the fragrances/perfumery sector. However, given the highest market share and traditional uses, labdanum resin also has the potential to be used and valued as a cosmetic ingredient for skincare. Aiming to evaluate this potential, labdanum methanolic absolute and fractions purified by column chromatography were characterized by UPLC-DAD-ESI-MS and then evaluated for UVprotection, antioxidant, anti-elastase, anti-inflammatory, and antimicrobial activities. Labdanum absolute represented ~70% of the resin; diterpenoid and flavonoid fractions represented ~75% and 15% of the absolute, respectively. Labdane-type diterpenoids and methylated flavonoids were the main compounds in labdanum absolute and in diterpenoid and flavonoid fractions, respectively. Labdanum absolute showed a spectrophotometric sun protection factor (SPF) near 5, which is mainly due to flavonoids, as the flavonoids’ SPF was 13. Low antioxidant activity was observed, with ABTS radical scavenging being the most significant (0.142 ± 0.017, 0.379 ± 0.039 and 0.010 ± 0.003 mgTE/mgExt, for the absolute and flavonoid and terpene fractions, respectively). Anti-aging and anti-inflammatory activity are reported here for the first time, by the inhibition of elastase activity (22% and 13%, by absolute and flavonoid extract at 1 mg/mL), and by the inhibition of nitric oxide production in LPS-induced RAW 264.7 cells (84% to 98%, at 15 µg/mL extracts, flavonoid fraction the most active), respectively. Antimicrobial activity, against relevant skin and cosmetic product microorganisms, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, and Escherichia coli, revealed that only S. aureus was susceptible to labdanum absolute (MIC: 1.2 mg/mL) and its fractions (MIC: <0.3 mg/mL). In conclusion, labdanum resin showed potential to be used in sunscreen cosmetics, anti-inflammatory skincare cosmeceuticals or medicines but has low potential as a cosmetic product preservative given the low antioxidant and low-spectrum antimicrobial activities. |
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Labdanum resin from Cistus ladanifer L.: a natural and sustainable ingredient for skin care cosmetics with relevant cosmeceutical bioactivitiesCistus landanifer L.Anti-inflammatoryAntimicrobialAntioxidantDiterpeneFlavonoidSunscreen effectRockroseLabdanum resin from Cistus ladanifer L. (Cistaceae) is an abundant natural resource in the Iberian Peninsula worth being explored in a sustainable manner. It is already used in the cosmetic industry; mainly by the fragrances/perfumery sector. However, given the highest market share and traditional uses, labdanum resin also has the potential to be used and valued as a cosmetic ingredient for skincare. Aiming to evaluate this potential, labdanum methanolic absolute and fractions purified by column chromatography were characterized by UPLC-DAD-ESI-MS and then evaluated for UVprotection, antioxidant, anti-elastase, anti-inflammatory, and antimicrobial activities. Labdanum absolute represented ~70% of the resin; diterpenoid and flavonoid fractions represented ~75% and 15% of the absolute, respectively. Labdane-type diterpenoids and methylated flavonoids were the main compounds in labdanum absolute and in diterpenoid and flavonoid fractions, respectively. Labdanum absolute showed a spectrophotometric sun protection factor (SPF) near 5, which is mainly due to flavonoids, as the flavonoids’ SPF was 13. Low antioxidant activity was observed, with ABTS radical scavenging being the most significant (0.142 ± 0.017, 0.379 ± 0.039 and 0.010 ± 0.003 mgTE/mgExt, for the absolute and flavonoid and terpene fractions, respectively). Anti-aging and anti-inflammatory activity are reported here for the first time, by the inhibition of elastase activity (22% and 13%, by absolute and flavonoid extract at 1 mg/mL), and by the inhibition of nitric oxide production in LPS-induced RAW 264.7 cells (84% to 98%, at 15 µg/mL extracts, flavonoid fraction the most active), respectively. Antimicrobial activity, against relevant skin and cosmetic product microorganisms, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, and Escherichia coli, revealed that only S. aureus was susceptible to labdanum absolute (MIC: 1.2 mg/mL) and its fractions (MIC: <0.3 mg/mL). In conclusion, labdanum resin showed potential to be used in sunscreen cosmetics, anti-inflammatory skincare cosmeceuticals or medicines but has low potential as a cosmetic product preservative given the low antioxidant and low-spectrum antimicrobial activities.Repositório Científico do Instituto Politécnico de Castelo BrancoFrazão, David F.Gomes, Carlos MartinsSteck, Jan L.Keller, JudithDelgado, F.M.G.Gonçalves, J. C.Bunzel, Mirko2022-11-03T16:31:39Z20222022-10-29T21:33:52Z2022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.11/8154engFRAZÃO, David F. [et. al.] (2022) - Labdanum resin from Cistus ladanifer L.: a natural and sustainable ingredient for skin care cosmetics with relevant cosmeceutical bioactivities. Plants. 11:1477. https://doi.org/ 10.3390/plants11111477cv-prod-300610810.3390/plants11111477info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-05-13T01:47:16Zoai:repositorio.ipcb.pt:10400.11/8154Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:38:34.505947Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Labdanum resin from Cistus ladanifer L.: a natural and sustainable ingredient for skin care cosmetics with relevant cosmeceutical bioactivities |
title |
Labdanum resin from Cistus ladanifer L.: a natural and sustainable ingredient for skin care cosmetics with relevant cosmeceutical bioactivities |
spellingShingle |
Labdanum resin from Cistus ladanifer L.: a natural and sustainable ingredient for skin care cosmetics with relevant cosmeceutical bioactivities Frazão, David F. Cistus landanifer L. Anti-inflammatory Antimicrobial Antioxidant Diterpene Flavonoid Sunscreen effect Rockrose |
title_short |
Labdanum resin from Cistus ladanifer L.: a natural and sustainable ingredient for skin care cosmetics with relevant cosmeceutical bioactivities |
title_full |
Labdanum resin from Cistus ladanifer L.: a natural and sustainable ingredient for skin care cosmetics with relevant cosmeceutical bioactivities |
title_fullStr |
Labdanum resin from Cistus ladanifer L.: a natural and sustainable ingredient for skin care cosmetics with relevant cosmeceutical bioactivities |
title_full_unstemmed |
Labdanum resin from Cistus ladanifer L.: a natural and sustainable ingredient for skin care cosmetics with relevant cosmeceutical bioactivities |
title_sort |
Labdanum resin from Cistus ladanifer L.: a natural and sustainable ingredient for skin care cosmetics with relevant cosmeceutical bioactivities |
author |
Frazão, David F. |
author_facet |
Frazão, David F. Gomes, Carlos Martins Steck, Jan L. Keller, Judith Delgado, F.M.G. Gonçalves, J. C. Bunzel, Mirko |
author_role |
author |
author2 |
Gomes, Carlos Martins Steck, Jan L. Keller, Judith Delgado, F.M.G. Gonçalves, J. C. Bunzel, Mirko |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico de Castelo Branco |
dc.contributor.author.fl_str_mv |
Frazão, David F. Gomes, Carlos Martins Steck, Jan L. Keller, Judith Delgado, F.M.G. Gonçalves, J. C. Bunzel, Mirko |
dc.subject.por.fl_str_mv |
Cistus landanifer L. Anti-inflammatory Antimicrobial Antioxidant Diterpene Flavonoid Sunscreen effect Rockrose |
topic |
Cistus landanifer L. Anti-inflammatory Antimicrobial Antioxidant Diterpene Flavonoid Sunscreen effect Rockrose |
description |
Labdanum resin from Cistus ladanifer L. (Cistaceae) is an abundant natural resource in the Iberian Peninsula worth being explored in a sustainable manner. It is already used in the cosmetic industry; mainly by the fragrances/perfumery sector. However, given the highest market share and traditional uses, labdanum resin also has the potential to be used and valued as a cosmetic ingredient for skincare. Aiming to evaluate this potential, labdanum methanolic absolute and fractions purified by column chromatography were characterized by UPLC-DAD-ESI-MS and then evaluated for UVprotection, antioxidant, anti-elastase, anti-inflammatory, and antimicrobial activities. Labdanum absolute represented ~70% of the resin; diterpenoid and flavonoid fractions represented ~75% and 15% of the absolute, respectively. Labdane-type diterpenoids and methylated flavonoids were the main compounds in labdanum absolute and in diterpenoid and flavonoid fractions, respectively. Labdanum absolute showed a spectrophotometric sun protection factor (SPF) near 5, which is mainly due to flavonoids, as the flavonoids’ SPF was 13. Low antioxidant activity was observed, with ABTS radical scavenging being the most significant (0.142 ± 0.017, 0.379 ± 0.039 and 0.010 ± 0.003 mgTE/mgExt, for the absolute and flavonoid and terpene fractions, respectively). Anti-aging and anti-inflammatory activity are reported here for the first time, by the inhibition of elastase activity (22% and 13%, by absolute and flavonoid extract at 1 mg/mL), and by the inhibition of nitric oxide production in LPS-induced RAW 264.7 cells (84% to 98%, at 15 µg/mL extracts, flavonoid fraction the most active), respectively. Antimicrobial activity, against relevant skin and cosmetic product microorganisms, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, and Escherichia coli, revealed that only S. aureus was susceptible to labdanum absolute (MIC: 1.2 mg/mL) and its fractions (MIC: <0.3 mg/mL). In conclusion, labdanum resin showed potential to be used in sunscreen cosmetics, anti-inflammatory skincare cosmeceuticals or medicines but has low potential as a cosmetic product preservative given the low antioxidant and low-spectrum antimicrobial activities. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-11-03T16:31:39Z 2022 2022-10-29T21:33:52Z 2022-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.11/8154 |
url |
http://hdl.handle.net/10400.11/8154 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
FRAZÃO, David F. [et. al.] (2022) - Labdanum resin from Cistus ladanifer L.: a natural and sustainable ingredient for skin care cosmetics with relevant cosmeceutical bioactivities. Plants. 11:1477. https://doi.org/ 10.3390/plants11111477 cv-prod-3006108 10.3390/plants11111477 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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