Systolic Time Ratio Measured by Impedance Cardiography Accurately Screens Left Ventricular Diastolic Dysfunction in Patients with Arterial Hypertension
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/2836 |
Resumo: | BACKGROUND: The use of impedance cardiography (ICG) may play a role in the assessment of cardiac effects of hypertension (HT), especially its hemodynamic features. Hypertensive heart disease involves structural changes and alterations in left ventricular geometry that end up causing systolic and/or diastolic dysfunction. The IMPEDDANS study aims to assess the usefulness of ICG for the screening of left ventricular diastolic dysfunction (LVDD) in patients with HT. METHODS: Patients with HT were assessed by echocardiography and ICG. Receiver-operating characteristic curve and the area under the curve were used to assess the discriminative ability of the parameters obtained by ICG to identify LVDD, as diagnosed by echocardiography. RESULTS: ICG derived pre-ejection period (PEP), left ventricle ejection time (LVET), systolic time ratio (STR) and D wave were associated (p < 0.001) with LVDD diagnosis, with good discriminative ability: PEP (AUC 0.81; 95% CI 0.74-0.89), LVET (AUC 0.82; 95% CI 0.75-0.88), STR (AUC 0.97; 95% CI 0.94-1.00) and presence of D wave (AUC = 0.87; 95% CI 0.82-0.93). STR ≥ 0.30 outperformed the other parameters (sensitivity of 98.0%, specificity of 90.2%, positive predictive value of 95.2%, and negative predictive value of 96.1%). CONCLUSION: The ICG derived value of STR allows the accurate screening of LVDD in patients with HT. It might as well be used for follow up assessment. TRIAL REGISTRATION: The study protocol was retrospectively registered as IMPEDDANS on ClinicalTrials.gov (ID: NCT03209141) on July 6, 2017. |
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Systolic Time Ratio Measured by Impedance Cardiography Accurately Screens Left Ventricular Diastolic Dysfunction in Patients with Arterial HypertensionHSJ MEDHSM MEDHSM CARCHLC CINVArterial HypertensionDiastolic DysfunctionImpedance CardiographySystolic Time RatioScreeningBACKGROUND: The use of impedance cardiography (ICG) may play a role in the assessment of cardiac effects of hypertension (HT), especially its hemodynamic features. Hypertensive heart disease involves structural changes and alterations in left ventricular geometry that end up causing systolic and/or diastolic dysfunction. The IMPEDDANS study aims to assess the usefulness of ICG for the screening of left ventricular diastolic dysfunction (LVDD) in patients with HT. METHODS: Patients with HT were assessed by echocardiography and ICG. Receiver-operating characteristic curve and the area under the curve were used to assess the discriminative ability of the parameters obtained by ICG to identify LVDD, as diagnosed by echocardiography. RESULTS: ICG derived pre-ejection period (PEP), left ventricle ejection time (LVET), systolic time ratio (STR) and D wave were associated (p < 0.001) with LVDD diagnosis, with good discriminative ability: PEP (AUC 0.81; 95% CI 0.74-0.89), LVET (AUC 0.82; 95% CI 0.75-0.88), STR (AUC 0.97; 95% CI 0.94-1.00) and presence of D wave (AUC = 0.87; 95% CI 0.82-0.93). STR ≥ 0.30 outperformed the other parameters (sensitivity of 98.0%, specificity of 90.2%, positive predictive value of 95.2%, and negative predictive value of 96.1%). CONCLUSION: The ICG derived value of STR allows the accurate screening of LVDD in patients with HT. It might as well be used for follow up assessment. TRIAL REGISTRATION: The study protocol was retrospectively registered as IMPEDDANS on ClinicalTrials.gov (ID: NCT03209141) on July 6, 2017.BioMed CentralRepositório do Centro Hospitalar Universitário de Lisboa Central, EPENazário Leão, RMarques da Silva, PBranco, LMFonseca, HBento, BAlves, MVirella, DPalma Reis, R2018-01-05T16:16:35Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/2836engClin Hypertens. 2017 Dec 27;23:2810.1186/s40885-017-0084-yinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:39:52Zoai:repositorio.chlc.min-saude.pt:10400.17/2836Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:20:10.243365Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Systolic Time Ratio Measured by Impedance Cardiography Accurately Screens Left Ventricular Diastolic Dysfunction in Patients with Arterial Hypertension |
title |
Systolic Time Ratio Measured by Impedance Cardiography Accurately Screens Left Ventricular Diastolic Dysfunction in Patients with Arterial Hypertension |
spellingShingle |
Systolic Time Ratio Measured by Impedance Cardiography Accurately Screens Left Ventricular Diastolic Dysfunction in Patients with Arterial Hypertension Nazário Leão, R HSJ MED HSM MED HSM CAR CHLC CINV Arterial Hypertension Diastolic Dysfunction Impedance Cardiography Systolic Time Ratio Screening |
title_short |
Systolic Time Ratio Measured by Impedance Cardiography Accurately Screens Left Ventricular Diastolic Dysfunction in Patients with Arterial Hypertension |
title_full |
Systolic Time Ratio Measured by Impedance Cardiography Accurately Screens Left Ventricular Diastolic Dysfunction in Patients with Arterial Hypertension |
title_fullStr |
Systolic Time Ratio Measured by Impedance Cardiography Accurately Screens Left Ventricular Diastolic Dysfunction in Patients with Arterial Hypertension |
title_full_unstemmed |
Systolic Time Ratio Measured by Impedance Cardiography Accurately Screens Left Ventricular Diastolic Dysfunction in Patients with Arterial Hypertension |
title_sort |
Systolic Time Ratio Measured by Impedance Cardiography Accurately Screens Left Ventricular Diastolic Dysfunction in Patients with Arterial Hypertension |
author |
Nazário Leão, R |
author_facet |
Nazário Leão, R Marques da Silva, P Branco, LM Fonseca, H Bento, B Alves, M Virella, D Palma Reis, R |
author_role |
author |
author2 |
Marques da Silva, P Branco, LM Fonseca, H Bento, B Alves, M Virella, D Palma Reis, R |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Nazário Leão, R Marques da Silva, P Branco, LM Fonseca, H Bento, B Alves, M Virella, D Palma Reis, R |
dc.subject.por.fl_str_mv |
HSJ MED HSM MED HSM CAR CHLC CINV Arterial Hypertension Diastolic Dysfunction Impedance Cardiography Systolic Time Ratio Screening |
topic |
HSJ MED HSM MED HSM CAR CHLC CINV Arterial Hypertension Diastolic Dysfunction Impedance Cardiography Systolic Time Ratio Screening |
description |
BACKGROUND: The use of impedance cardiography (ICG) may play a role in the assessment of cardiac effects of hypertension (HT), especially its hemodynamic features. Hypertensive heart disease involves structural changes and alterations in left ventricular geometry that end up causing systolic and/or diastolic dysfunction. The IMPEDDANS study aims to assess the usefulness of ICG for the screening of left ventricular diastolic dysfunction (LVDD) in patients with HT. METHODS: Patients with HT were assessed by echocardiography and ICG. Receiver-operating characteristic curve and the area under the curve were used to assess the discriminative ability of the parameters obtained by ICG to identify LVDD, as diagnosed by echocardiography. RESULTS: ICG derived pre-ejection period (PEP), left ventricle ejection time (LVET), systolic time ratio (STR) and D wave were associated (p < 0.001) with LVDD diagnosis, with good discriminative ability: PEP (AUC 0.81; 95% CI 0.74-0.89), LVET (AUC 0.82; 95% CI 0.75-0.88), STR (AUC 0.97; 95% CI 0.94-1.00) and presence of D wave (AUC = 0.87; 95% CI 0.82-0.93). STR ≥ 0.30 outperformed the other parameters (sensitivity of 98.0%, specificity of 90.2%, positive predictive value of 95.2%, and negative predictive value of 96.1%). CONCLUSION: The ICG derived value of STR allows the accurate screening of LVDD in patients with HT. It might as well be used for follow up assessment. TRIAL REGISTRATION: The study protocol was retrospectively registered as IMPEDDANS on ClinicalTrials.gov (ID: NCT03209141) on July 6, 2017. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z 2018-01-05T16:16:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/2836 |
url |
http://hdl.handle.net/10400.17/2836 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clin Hypertens. 2017 Dec 27;23:28 10.1186/s40885-017-0084-y |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
BioMed Central |
publisher.none.fl_str_mv |
BioMed Central |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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