Peripheral axonal ensheathment is regulated by RalA GTPase and the exocyst complex

Detalhes bibliográficos
Autor(a) principal: Silva-Rodrigues, Joana F.
Data de Publicação: 2020
Outros Autores: Patrício-Rodrigues, Cátia F., de Sousa-Xavier, Vicente, Augusto, Pedro M., Fernandes, Ana C., Farinho, Ana R., Martins, João P., Teodoro, Rita O.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/147801
Resumo: Funding This work was supported by H2020 Marie Skłodowska-Curie Actions [H2020- GA661543-Neuronal Trafficking to R.O.T.], Fundo Regional para a Ciência e Tecnologia [IF/00392/2013/CP1192/CT0002 to R.O.T.] and iNOVA4Health (UID/Multi/04462/2013) (co-funded by FCT-FEDER-PT2020).
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spelling Peripheral axonal ensheathment is regulated by RalA GTPase and the exocyst complexAxonal ensheathmentDrosophilaExocystRalA GTPaseWrapping gliaMolecular BiologyDevelopmental BiologyFunding This work was supported by H2020 Marie Skłodowska-Curie Actions [H2020- GA661543-Neuronal Trafficking to R.O.T.], Fundo Regional para a Ciência e Tecnologia [IF/00392/2013/CP1192/CT0002 to R.O.T.] and iNOVA4Health (UID/Multi/04462/2013) (co-funded by FCT-FEDER-PT2020).Axon ensheathment is fundamental for fast impulse conduction and the normal physiological functioning of the nervous system. Defects in axonal insulation lead to debilitating conditions, but, despite its importance, the molecular players responsible are poorly defined. Here, we identify RalA GTPase as a key player in axon ensheathment in Drosophila larval peripheral nerves. We demonstrate through genetic analysis that RalA action through the exocyst complex is required in wrapping glial cells to regulate their growth and development. We suggest that the RalA-exocyst pathway controls the targeting of secretory vesicles for membrane growth or for the secretion of a wrapping glia-derived factor that itself regulates growth. In summary, our findings provide a new molecular understanding of the process by which axons are ensheathed in vivo, a process that is crucial for normal neuronal function.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNSilva-Rodrigues, Joana F.Patrício-Rodrigues, Cátia F.de Sousa-Xavier, VicenteAugusto, Pedro M.Fernandes, Ana C.Farinho, Ana R.Martins, João P.Teodoro, Rita O.2023-01-18T22:14:03Z2020-02-042020-02-04T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/147801eng0950-1991PURE: 16879943https://doi.org/10.1242/dev.174540info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:29:01Zoai:run.unl.pt:10362/147801Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:53:04.961719Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Peripheral axonal ensheathment is regulated by RalA GTPase and the exocyst complex
title Peripheral axonal ensheathment is regulated by RalA GTPase and the exocyst complex
spellingShingle Peripheral axonal ensheathment is regulated by RalA GTPase and the exocyst complex
Silva-Rodrigues, Joana F.
Axonal ensheathment
Drosophila
Exocyst
RalA GTPase
Wrapping glia
Molecular Biology
Developmental Biology
title_short Peripheral axonal ensheathment is regulated by RalA GTPase and the exocyst complex
title_full Peripheral axonal ensheathment is regulated by RalA GTPase and the exocyst complex
title_fullStr Peripheral axonal ensheathment is regulated by RalA GTPase and the exocyst complex
title_full_unstemmed Peripheral axonal ensheathment is regulated by RalA GTPase and the exocyst complex
title_sort Peripheral axonal ensheathment is regulated by RalA GTPase and the exocyst complex
author Silva-Rodrigues, Joana F.
author_facet Silva-Rodrigues, Joana F.
Patrício-Rodrigues, Cátia F.
de Sousa-Xavier, Vicente
Augusto, Pedro M.
Fernandes, Ana C.
Farinho, Ana R.
Martins, João P.
Teodoro, Rita O.
author_role author
author2 Patrício-Rodrigues, Cátia F.
de Sousa-Xavier, Vicente
Augusto, Pedro M.
Fernandes, Ana C.
Farinho, Ana R.
Martins, João P.
Teodoro, Rita O.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Silva-Rodrigues, Joana F.
Patrício-Rodrigues, Cátia F.
de Sousa-Xavier, Vicente
Augusto, Pedro M.
Fernandes, Ana C.
Farinho, Ana R.
Martins, João P.
Teodoro, Rita O.
dc.subject.por.fl_str_mv Axonal ensheathment
Drosophila
Exocyst
RalA GTPase
Wrapping glia
Molecular Biology
Developmental Biology
topic Axonal ensheathment
Drosophila
Exocyst
RalA GTPase
Wrapping glia
Molecular Biology
Developmental Biology
description Funding This work was supported by H2020 Marie Skłodowska-Curie Actions [H2020- GA661543-Neuronal Trafficking to R.O.T.], Fundo Regional para a Ciência e Tecnologia [IF/00392/2013/CP1192/CT0002 to R.O.T.] and iNOVA4Health (UID/Multi/04462/2013) (co-funded by FCT-FEDER-PT2020).
publishDate 2020
dc.date.none.fl_str_mv 2020-02-04
2020-02-04T00:00:00Z
2023-01-18T22:14:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/147801
url http://hdl.handle.net/10362/147801
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0950-1991
PURE: 16879943
https://doi.org/10.1242/dev.174540
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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