The Early Postnatal Life: A Dynamic Period in Thymic Epithelial Cell Differentiation

Detalhes bibliográficos
Autor(a) principal: Pinheiro, RGR
Data de Publicação: 2021
Outros Autores: Alves, NL
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/152442
Resumo: The microenvironments formed by cortical (c) and medullary (m) thymic epithelial cells (TECs) play a non-redundant role in the generation of functionally diverse and self-tolerant T cells. The role of TECs during the first weeks of the murine postnatal life is particularly challenging due to the significant augment in T cell production. Here, we critically review recent studies centered on the timely coordination between the expansion and maturation of TECs during this period and their specialized role in T cell development and selection. We further discuss how aging impacts on the pool of TEC progenitors and maintenance of functionally thymic epithelial microenvironments, and the implications of these chances in the capacity of the thymus to sustain regular thymopoiesis throughout life.
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spelling The Early Postnatal Life: A Dynamic Period in Thymic Epithelial Cell DifferentiationAgingEarly postnatal lifeThymic epithelial cellsThymusToleranceThe microenvironments formed by cortical (c) and medullary (m) thymic epithelial cells (TECs) play a non-redundant role in the generation of functionally diverse and self-tolerant T cells. The role of TECs during the first weeks of the murine postnatal life is particularly challenging due to the significant augment in T cell production. Here, we critically review recent studies centered on the timely coordination between the expansion and maturation of TECs during this period and their specialized role in T cell development and selection. We further discuss how aging impacts on the pool of TEC progenitors and maintenance of functionally thymic epithelial microenvironments, and the implications of these chances in the capacity of the thymus to sustain regular thymopoiesis throughout life.Frontiers Media20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/152442eng1664-322410.3389/fimmu.2021.668528Pinheiro, RGRAlves, NLinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T13:35:51Zoai:repositorio-aberto.up.pt:10216/152442Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:43:26.414078Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The Early Postnatal Life: A Dynamic Period in Thymic Epithelial Cell Differentiation
title The Early Postnatal Life: A Dynamic Period in Thymic Epithelial Cell Differentiation
spellingShingle The Early Postnatal Life: A Dynamic Period in Thymic Epithelial Cell Differentiation
Pinheiro, RGR
Aging
Early postnatal life
Thymic epithelial cells
Thymus
Tolerance
title_short The Early Postnatal Life: A Dynamic Period in Thymic Epithelial Cell Differentiation
title_full The Early Postnatal Life: A Dynamic Period in Thymic Epithelial Cell Differentiation
title_fullStr The Early Postnatal Life: A Dynamic Period in Thymic Epithelial Cell Differentiation
title_full_unstemmed The Early Postnatal Life: A Dynamic Period in Thymic Epithelial Cell Differentiation
title_sort The Early Postnatal Life: A Dynamic Period in Thymic Epithelial Cell Differentiation
author Pinheiro, RGR
author_facet Pinheiro, RGR
Alves, NL
author_role author
author2 Alves, NL
author2_role author
dc.contributor.author.fl_str_mv Pinheiro, RGR
Alves, NL
dc.subject.por.fl_str_mv Aging
Early postnatal life
Thymic epithelial cells
Thymus
Tolerance
topic Aging
Early postnatal life
Thymic epithelial cells
Thymus
Tolerance
description The microenvironments formed by cortical (c) and medullary (m) thymic epithelial cells (TECs) play a non-redundant role in the generation of functionally diverse and self-tolerant T cells. The role of TECs during the first weeks of the murine postnatal life is particularly challenging due to the significant augment in T cell production. Here, we critically review recent studies centered on the timely coordination between the expansion and maturation of TECs during this period and their specialized role in T cell development and selection. We further discuss how aging impacts on the pool of TEC progenitors and maintenance of functionally thymic epithelial microenvironments, and the implications of these chances in the capacity of the thymus to sustain regular thymopoiesis throughout life.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/152442
url https://hdl.handle.net/10216/152442
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1664-3224
10.3389/fimmu.2021.668528
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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