THE OPPORTUNITY FOR BALANCING SELECTION IN EXPERIMENTAL POPULATIONS OFCAENORHABDITIS ELEGANS
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.7/810 |
Resumo: | The deposited article is a Post-print version and has been submitted to peer reviewing. This publication hasn't any creative commons license associated. This deposit is composed by the main article plus the supplementary materials of the publication. |
| id |
RCAP_500be391b2d7224c5365dcfcebdcab42 |
|---|---|
| oai_identifier_str |
oai:arca.igc.gulbenkian.pt:10400.7/810 |
| network_acronym_str |
RCAP |
| network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository_id_str |
7160 |
| spelling |
THE OPPORTUNITY FOR BALANCING SELECTION IN EXPERIMENTAL POPULATIONS OFCAENORHABDITIS ELEGANSAdaptationepistasisevolutionary genomicsfitnessinbreedingpopulation structureThe deposited article is a Post-print version and has been submitted to peer reviewing. This publication hasn't any creative commons license associated. This deposit is composed by the main article plus the supplementary materials of the publication.The role of balancing selection in maintaining diversity during the evolution of sexual populations to novel environments is poorly understood. To address this issue, we studied the impact of two mating systems, androdioecy and dioecy, on genotype distributions during the experimental evolution of Caenorhabditis elegans. We analyzed the temporal trajectories of 334 single nucleotide polymorphisms, covering 1/3 of the genome, and found extensive allele frequency changes and little loss of heterozygosities after 100 generations. As modeled with numerical simulations, SNP differentiation was consistent with genetic drift and average fitness effects of 2%, assuming that selection acted independently at each locus. Remarkably, inbreeding by self-fertilization was of little consequence to SNP differentiation. Modeling selection on deleterious recessive alleles suggests that the initial evolutionary dynamics can be explained by associative overdominance, but not the later stages because much lower heterozygosities would be maintained during experimental evolution. By contrast, models with selection on true overdominant loci can explain the heterozygote excess observed at all periods, particularly when negative epistasis or independent fitness effects were considered. Overall, these findings indicate that selection at single loci, including purging of recessive alleles, underlies most of the genetic differentiation accomplished during the experiment. Nonetheless, they also imply that maintenance of genetic diversity may in large part be due to balancing selection at multiple loci.European Research Council grant: (stERC/2009-243285).WileyARCAChelo, Ivo M.Teotónio, Henrique2017-11-22T15:04:34Z2013-01-042013-01-04T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheethttp://hdl.handle.net/10400.7/810engChelo, I. M. and Teotónio, H. (2013), THE OPPORTUNITY FOR BALANCING SELECTION IN EXPERIMENTAL POPULATIONS OF CAENORHABDITIS ELEGANS. Evolution, 67: 142–156. doi:10.1111/j.1558-5646.2012.01744.x10.1111/j.1558-5646.2012.01744.xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:13Zoai:arca.igc.gulbenkian.pt:10400.7/810Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:12:02.121557Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
THE OPPORTUNITY FOR BALANCING SELECTION IN EXPERIMENTAL POPULATIONS OFCAENORHABDITIS ELEGANS |
| title |
THE OPPORTUNITY FOR BALANCING SELECTION IN EXPERIMENTAL POPULATIONS OFCAENORHABDITIS ELEGANS |
| spellingShingle |
THE OPPORTUNITY FOR BALANCING SELECTION IN EXPERIMENTAL POPULATIONS OFCAENORHABDITIS ELEGANS Chelo, Ivo M. Adaptation epistasis evolutionary genomics fitness inbreeding population structure |
| title_short |
THE OPPORTUNITY FOR BALANCING SELECTION IN EXPERIMENTAL POPULATIONS OFCAENORHABDITIS ELEGANS |
| title_full |
THE OPPORTUNITY FOR BALANCING SELECTION IN EXPERIMENTAL POPULATIONS OFCAENORHABDITIS ELEGANS |
| title_fullStr |
THE OPPORTUNITY FOR BALANCING SELECTION IN EXPERIMENTAL POPULATIONS OFCAENORHABDITIS ELEGANS |
| title_full_unstemmed |
THE OPPORTUNITY FOR BALANCING SELECTION IN EXPERIMENTAL POPULATIONS OFCAENORHABDITIS ELEGANS |
| title_sort |
THE OPPORTUNITY FOR BALANCING SELECTION IN EXPERIMENTAL POPULATIONS OFCAENORHABDITIS ELEGANS |
| author |
Chelo, Ivo M. |
| author_facet |
Chelo, Ivo M. Teotónio, Henrique |
| author_role |
author |
| author2 |
Teotónio, Henrique |
| author2_role |
author |
| dc.contributor.none.fl_str_mv |
ARCA |
| dc.contributor.author.fl_str_mv |
Chelo, Ivo M. Teotónio, Henrique |
| dc.subject.por.fl_str_mv |
Adaptation epistasis evolutionary genomics fitness inbreeding population structure |
| topic |
Adaptation epistasis evolutionary genomics fitness inbreeding population structure |
| description |
The deposited article is a Post-print version and has been submitted to peer reviewing. This publication hasn't any creative commons license associated. This deposit is composed by the main article plus the supplementary materials of the publication. |
| publishDate |
2013 |
| dc.date.none.fl_str_mv |
2013-01-04 2013-01-04T00:00:00Z 2017-11-22T15:04:34Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.7/810 |
| url |
http://hdl.handle.net/10400.7/810 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Chelo, I. M. and Teotónio, H. (2013), THE OPPORTUNITY FOR BALANCING SELECTION IN EXPERIMENTAL POPULATIONS OF CAENORHABDITIS ELEGANS. Evolution, 67: 142–156. doi:10.1111/j.1558-5646.2012.01744.x 10.1111/j.1558-5646.2012.01744.x |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf application/pdf application/vnd.openxmlformats-officedocument.spreadsheetml.sheet |
| dc.publisher.none.fl_str_mv |
Wiley |
| publisher.none.fl_str_mv |
Wiley |
| dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
| instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| repository.mail.fl_str_mv |
|
| _version_ |
1799130575801417728 |