HPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.1016/j.pvr.2016.02.003 |
Resumo: | Objectives To determine human papillomavirus (HPV) types in invasive cervical cancer in Portugal. Methods Cases diagnosed at the Instituto Português de Oncologia de Lisboa de Francisco Gentil from the year 1928 to 2005 were selected for HPV DNA detection and genotyping using SPF10/DEIA/LiPA25 system. Results Of the 1214 samples that were considered appropriate for HPV detection, 714 (58.8%; 95% CI: 56.0–61.6%) were positive for HPV DNA. This detection rate varied being lower in the first 3 decades (31.3%; 50.1%; 46.5%) and higher in the last decades (77.4–95.1%). This difference was due probably to the fixative used in the first three decades. The five most common types identified among HPV positive cases were HPV16 (58.2%), HPV18 (9.2%), HPV33 (6.2%), HPV45 (4.7%) and HPV31 (4.4%). Multiple infections were detected in 2.8% of the cases. HPV16 and 18 accounted for 67.4% of infections. There were no statistically significant changes of these types over the studied period. An increase at patient׳s age at diagnosis was observed in the last decades (p |
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HPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005HPVInvasive cervical carcinomaPortugalRetrospective studyadultagedArticlecohort analysiscontrolled studyfemalegenotypehumanHuman papillomavirus type 11Human papillomavirus type 16Human papillomavirus type 18Human papillomavirus type 30Human papillomavirus type 31Human papillomavirus type 33Human papillomavirus type 35Human papillomavirus type 39Human papillomavirus type 42Human papillomavirus type 45Human papillomavirus type 51Human papillomavirus type 52Human papillomavirus type 53Human papillomavirus type 56Human papillomavirus type 58Human papillomavirus type 59Human papillomavirus type 66Human papillomavirus type 67Human papillomavirus type 68Human papillomavirus type 69Human papillomavirus type 70Human papillomavirus type 73Human papillomavirus type 91major clinical studynonhumanpriority journalretrospective studyuterine cervix cancervirus detectionWart virusSDG 3 - Good Health and Well-beingObjectives To determine human papillomavirus (HPV) types in invasive cervical cancer in Portugal. Methods Cases diagnosed at the Instituto Português de Oncologia de Lisboa de Francisco Gentil from the year 1928 to 2005 were selected for HPV DNA detection and genotyping using SPF10/DEIA/LiPA25 system. Results Of the 1214 samples that were considered appropriate for HPV detection, 714 (58.8%; 95% CI: 56.0–61.6%) were positive for HPV DNA. This detection rate varied being lower in the first 3 decades (31.3%; 50.1%; 46.5%) and higher in the last decades (77.4–95.1%). This difference was due probably to the fixative used in the first three decades. The five most common types identified among HPV positive cases were HPV16 (58.2%), HPV18 (9.2%), HPV33 (6.2%), HPV45 (4.7%) and HPV31 (4.4%). Multiple infections were detected in 2.8% of the cases. HPV16 and 18 accounted for 67.4% of infections. There were no statistically significant changes of these types over the studied period. An increase at patient׳s age at diagnosis was observed in the last decades (pCentro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNFélix, A.Alemany, L.Tous, S.de Sanjosé, S.Bosch, F.X.2018-06-30T00:17:38Z2016-122016-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article5application/pdfhttps://doi.org/10.1016/j.pvr.2016.02.003eng2405-8521PURE: 3163913https://www.scopus.com/inward/record.uri?eid=2-s2.0-85000402144&doi=10.1016%2fj.pvr.2016.02.003&partnerID=40&md5=884a603a7c0d59095119f29f1857cb6dhttps://doi.org/10.1016/j.pvr.2016.02.003info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:22:04Zoai:run.unl.pt:10362/40519Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:31:15.935450Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
HPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005 |
title |
HPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005 |
spellingShingle |
HPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005 Félix, A. HPV Invasive cervical carcinoma Portugal Retrospective study adult aged Article cohort analysis controlled study female genotype human Human papillomavirus type 11 Human papillomavirus type 16 Human papillomavirus type 18 Human papillomavirus type 30 Human papillomavirus type 31 Human papillomavirus type 33 Human papillomavirus type 35 Human papillomavirus type 39 Human papillomavirus type 42 Human papillomavirus type 45 Human papillomavirus type 51 Human papillomavirus type 52 Human papillomavirus type 53 Human papillomavirus type 56 Human papillomavirus type 58 Human papillomavirus type 59 Human papillomavirus type 66 Human papillomavirus type 67 Human papillomavirus type 68 Human papillomavirus type 69 Human papillomavirus type 70 Human papillomavirus type 73 Human papillomavirus type 91 major clinical study nonhuman priority journal retrospective study uterine cervix cancer virus detection Wart virus SDG 3 - Good Health and Well-being |
title_short |
HPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005 |
title_full |
HPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005 |
title_fullStr |
HPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005 |
title_full_unstemmed |
HPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005 |
title_sort |
HPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005 |
author |
Félix, A. |
author_facet |
Félix, A. Alemany, L. Tous, S. de Sanjosé, S. Bosch, F.X. |
author_role |
author |
author2 |
Alemany, L. Tous, S. de Sanjosé, S. Bosch, F.X. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Félix, A. Alemany, L. Tous, S. de Sanjosé, S. Bosch, F.X. |
dc.subject.por.fl_str_mv |
HPV Invasive cervical carcinoma Portugal Retrospective study adult aged Article cohort analysis controlled study female genotype human Human papillomavirus type 11 Human papillomavirus type 16 Human papillomavirus type 18 Human papillomavirus type 30 Human papillomavirus type 31 Human papillomavirus type 33 Human papillomavirus type 35 Human papillomavirus type 39 Human papillomavirus type 42 Human papillomavirus type 45 Human papillomavirus type 51 Human papillomavirus type 52 Human papillomavirus type 53 Human papillomavirus type 56 Human papillomavirus type 58 Human papillomavirus type 59 Human papillomavirus type 66 Human papillomavirus type 67 Human papillomavirus type 68 Human papillomavirus type 69 Human papillomavirus type 70 Human papillomavirus type 73 Human papillomavirus type 91 major clinical study nonhuman priority journal retrospective study uterine cervix cancer virus detection Wart virus SDG 3 - Good Health and Well-being |
topic |
HPV Invasive cervical carcinoma Portugal Retrospective study adult aged Article cohort analysis controlled study female genotype human Human papillomavirus type 11 Human papillomavirus type 16 Human papillomavirus type 18 Human papillomavirus type 30 Human papillomavirus type 31 Human papillomavirus type 33 Human papillomavirus type 35 Human papillomavirus type 39 Human papillomavirus type 42 Human papillomavirus type 45 Human papillomavirus type 51 Human papillomavirus type 52 Human papillomavirus type 53 Human papillomavirus type 56 Human papillomavirus type 58 Human papillomavirus type 59 Human papillomavirus type 66 Human papillomavirus type 67 Human papillomavirus type 68 Human papillomavirus type 69 Human papillomavirus type 70 Human papillomavirus type 73 Human papillomavirus type 91 major clinical study nonhuman priority journal retrospective study uterine cervix cancer virus detection Wart virus SDG 3 - Good Health and Well-being |
description |
Objectives To determine human papillomavirus (HPV) types in invasive cervical cancer in Portugal. Methods Cases diagnosed at the Instituto Português de Oncologia de Lisboa de Francisco Gentil from the year 1928 to 2005 were selected for HPV DNA detection and genotyping using SPF10/DEIA/LiPA25 system. Results Of the 1214 samples that were considered appropriate for HPV detection, 714 (58.8%; 95% CI: 56.0–61.6%) were positive for HPV DNA. This detection rate varied being lower in the first 3 decades (31.3%; 50.1%; 46.5%) and higher in the last decades (77.4–95.1%). This difference was due probably to the fixative used in the first three decades. The five most common types identified among HPV positive cases were HPV16 (58.2%), HPV18 (9.2%), HPV33 (6.2%), HPV45 (4.7%) and HPV31 (4.4%). Multiple infections were detected in 2.8% of the cases. HPV16 and 18 accounted for 67.4% of infections. There were no statistically significant changes of these types over the studied period. An increase at patient׳s age at diagnosis was observed in the last decades (p |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-12 2016-12-01T00:00:00Z 2018-06-30T00:17:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1016/j.pvr.2016.02.003 |
url |
https://doi.org/10.1016/j.pvr.2016.02.003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2405-8521 PURE: 3163913 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85000402144&doi=10.1016%2fj.pvr.2016.02.003&partnerID=40&md5=884a603a7c0d59095119f29f1857cb6d https://doi.org/10.1016/j.pvr.2016.02.003 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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5 application/pdf |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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